MCM-2 expression differentiates potentially malignant verrucous lesions from oral carcinomas

C, Niranjan K; Sarathy, Niharika Abhay; Alrani, Devendra

doi:10.1016/j.anndiagpath.2018.03.001

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…MCMs are considered specific biomarkers of cell proliferation because MCMs are highly expressed in proliferating cells but have no or poor expression in stationary or well-differentiated cells [ 28 ]. Studies have shown that MCM2, a member of the MCM family, is overexpressed in OSCC and serves as an effective biomarker for OSCC [ 29 , 30 ]. A previous transcriptome analysis suggested MCM2 as a pan-cancer biomarker [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis

Liu

Xie

2022

BMC Oral Health

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Background Key lncRNAs associated with the malignant progression of oral submucous fibrosis (OSF) to oral squamous cell carcinoma (OSCC) were identified. Methods Key lncRNAs with sequential changes from normal oral mucosa (NOM) to OSF to OSCC were identified based on the GEO database. Kaplan–Meier analysis was used to screen lncRNAs related to OSCC prognosis. Cox regression analysis was used to validate the independent prognostic value. qPCR was used to confirm the expression of the candidate lncRNAs. Gene set enrichment analysis (GSEA), nucleocytoplasmic separation assay, fluorescence in situ hybridization, RNA knockdown, western blot, and cell viability assay were performed to investigate the biological functions of the candidate lncRNA. A nomogram was constructed to quantitatively predict OSCC prognosis based on TCGA. Results Bioinformatics methods indicated that LINC02147 was sequentially downregulated from NOM to OSF to OSCC, as confirmed by clinical tissues and cells. Meanwhile, low LINC02147 expression, as an independent prognostic factor, predicted a poor prognosis for OSCC. GSEA and in vitro studies suggested that low LINC02147 expression promoted OSF malignant progression by promoting cell proliferation and differentiation. A LINC02147 signature-based nomogram successfully quantified each indicator’s contribution to the overall survival of OSCC. Conclusions Low LINC02147 expression promoted OSF malignant progression and predicted poor OSCC prognosis.

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Section: Discussionmentioning

confidence: 99%

Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis

Liu

Xie

2022

BMC Oral Health

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Molecular landscape of proliferative verrucous leukoplakia: a systematic review

Nissanka-Jayasuriya,

Fenton,

Rose-Zerilli

2024

British Journal of Oral and Maxillofacial Surgery

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Proteomic Screening and Verification of Biomarkers in Different Stages of Mycosis Fungoides: A pilot Study

Gan

Shi

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; in advanced stages, it can involve multiple organs and has a poor prognosis. Early detection of the disease is still urgent, but there is no optimal therapy for advanced MF. In the present study, quantitative proteomic analyses (label-free quantitation, LFQ) were applied to tissue samples of different stages of MF and tissue samples from controls (eczema patients and healthy donors) to conduct preliminary molecular analysis to clarify the pathogenesis of the disease. Differential protein expression analysis demonstrated that 113 and 305 proteins were associated with the early and advanced stages of MF, respectively. Gene ontology (GO) enrichment analysis was conducted to determine the potential functions of the proteins, which could be classified into three categories: biological process, cellular component, and molecular function. The results revealed that a series of biological processes, including “initiation of DNA replication” and “nucleosome assembly,” were involved in the disease. Moreover, cellular components, including the “desmosome” and “integrin complex,” may affect the invasion and metastasis of MF via molecular functions, including “integrin binding” and “cadherin binding”. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis demonstrated that “focal adhesion DNA replication,” “Toll-like receptor signalling pathway” and other pathways were also involved. A parallel reaction monitoring (PRM) assay was applied to validate the identified differentially expressed proteins. In conclusion, the above proteomic findings may have great diagnostic and prognostic value in diverse malignancies, especially MF. Nevertheless, further studies are still needed to explore the precise mechanisms of MF.

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MCM-2 expression differentiates potentially malignant verrucous lesions from oral carcinomas

Cited by 4 publications

References 15 publications

Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis

Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis

Molecular landscape of proliferative verrucous leukoplakia: a systematic review

Proteomic Screening and Verification of Biomarkers in Different Stages of Mycosis Fungoides: A pilot Study

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