MCL-1 Promoter Insertions Dial-Up Aggressiveness of Chronic Leukemia

Kitada, Shinichi; Reed, John C.

doi:10.1093/jnci/djh153

Cited by 26 publications

(21 citation statements)

References 17 publications

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“…41 Our evaluation of B-PAC-1 activity with various microenvironmental factors revealed that bone marrow stromal cells (NKTert), IL-6 (cytokine), and anti-IgM (BCR activation) did not modulate B-PAC-1-induced apoptosis ( Figure 3A-B). This finding goes in line with the notion that the protective microenvironment that induces Mcl-1, 19 IAPs, 28 AKT, and extracellular signalregulated kinase (ERK) 21,42 does not interfere with the course of B-PAC-1-induced apoptosis as its target is at the terminus.…”

Section: Discussionsupporting

confidence: 85%

Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells

Patel

Balakrishnan

Keating

et al. 2015

Blood

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Section: Discussionsupporting

confidence: 85%

Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells

Patel

Balakrishnan

Keating

et al. 2015

Blood

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“…Mcl-1 expression is emerging as a prognostic determinant of outcome and response. 42 Our finding that honokiol overcomes the apoptosis resistance present in B-CLL cells at least in part by downregulation of Mcl-1 bears potential significant clinical relevance.…”

Section: Discussionmentioning

confidence: 82%

The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells

Battle

Arbiser

Frank

2005

Blood

181

161

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“…Mcl-1 expression is emerging as a prognostic determinant of outcome and response. 45 Our finding that treatment of B-CLL cells with deguelin downregulates the Mcl-1 expression may bear significant clinical relevance.…”

Section: Discussionmentioning

confidence: 84%

Deguelin inhibits expression of IκBα protein and induces apoptosis of B-CLL cells in vitro

et al. 2007

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We investigated if deguelin, a naturally occurring rotenoid, was able to inhibit nuclear factor kappa B (NF-jB)-binding protein (IjBa) expression and to induce apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells in vitro. Deguelin-induced cell death in the majority of B-CLL cells and was found to be more toxic toward B-CLL cells than to the normal mononuclear or B-cells, suggesting selectivity towards the malignant cells. Deguelin was found to reduce IjBa protein expression, and thus interacts with the NFjB pathway. The induced apoptosis was characterized by processing of caspase-9 and -3 and poly-(ADP)-ribose-polymerase cleavage. Exposure of B-CLL cells to deguelin resulted in Bcl2-associated protein (Bax) conformational changes and downregulation of the key survival protein myeloid cell leukemia sequence 1 (Mcl-1), which is associated with response to treatment in B-CLL patients. Deguelin retained its ability to induce apoptosis in B-CLL cells in the presence of interleukin-4, a pro-survival cytokine in B-CLL, and when cultured with 50% human serum. These data indicate that deguelin is able to induce apoptosis in B-CLL cells in the presence of pro-survival signals and thus merits further investigation for clinical application either as a single agent or in combination with other anticancer agents.

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MCL-1 Promoter Insertions Dial-Up Aggressiveness of Chronic Leukemia

Cited by 26 publications

References 17 publications

Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells

Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells

The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells

Deguelin inhibits expression of IκBα protein and induces apoptosis of B-CLL cells in vitro

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