mcIRBP-19 of Bitter Melon Peptide Effectively Regulates Diabetes Mellitus (DM) Patients’ Blood Sugar Levels

Abstract

This study was conducted to test the effectiveness of a particular bitter melon peptide (BMP), with a specific sequence of 19 amino acids (mcIRBP-19), in regulating diabetic patients’ blood glucose. In order to test the product with the specially processed BMP, a total of 142 diabetic patients were solicited as study subjects, of which 64 were assigned to an experiment group and 78 to a control group. Biochemical data were compared with a paired t-test to verify the significance of changes over different time periods. The clinical results showed that BMP started to improve the subjects’ glycated hemoglobin (HbA1c) levels at the end of the second month (T2), with mean values being significantly lowered from 7.8 ± 1.4% (T0) to 7.5 ± 1.4% (T2) (p = 0.004). The values reduced continuously, eventually reaching 7.4 ± 1.1% (p = 0.000) at the end of the experiment (T3). HbA1c levels for the control group were 7.5 ± 1.2% in T0 and 7.5 ± 1.1% (T3), and not significantly different (p = 0.852) over the same period. This study provides clinical evidence that helps to verify the effectiveness of the new BMP product in regulating diabetic patients’ blood sugar levels.

Effects of selected herbal supplements in persons with type 2 diabetes

“…Whereas serum HDL cholesterol on the 90 th day was higher in a group by 10% (p=0.015) receiving only fenugreek seeds as supplementation (Table 2 This study found that FBS and PPBS are significantly reduced with add on therapy with both MC and TFG which is in consistent with the beneficial effects of MC and TFG in other studies. 6,[8][9][10][11] It has been proposed that fenugreek seeds in humans and animals attenuate glucose tolerance and improvement in glucose-induced insulin response, thereby ratifying the potential hypoglycemic activity of fenugreek seeds. 10 Studies reveal the hypoglycemic effect of MC is due to its ability to maintain structural integrity of pancreatic islets and release of hormones and the presence of charantine, vicine, and polypeptide like active components that have structural similarity with human insulin.…”

<p>Exploring the Factors Affecting Bitter Melon Peptide Intake Behavior: A Health Belief Model Perspective</p>

“…A structured questionnaire was developed based on the HBM 9 and revised with a pre-test with 50 subjects with good levels of reliability and validity. A 5-point scale was applied to measure the responses of each construct to the items.…”

“…Participants were asked to complete the survey voluntarily and to provide written informed consent with a signature prior to the investigation process. Participants were also requested to read the document of product description regarding the information on test results 9 of the captioned BMP nutraceutical as well as dose information and the selling price before entering the answering process.…”

“…[3][4][5][6] Bitter melon peptide (BMP) is one of the products that is recently developed and has received wide attention. [4][5][6][7][8][9] BMP with mcIRBP-19 (named as Insumate ® ) was developed and launched to the Taiwan market as a nutraceutical, it has been proven to be effective in regulating DM patient blood glucose levels. 9 Other than prescribed medications, taking this particular BMP as an aid to regulate blood sugar has become common in Taiwan since its introduction.…”

“…[4][5][6][7][8][9] BMP with mcIRBP-19 (named as Insumate ® ) was developed and launched to the Taiwan market as a nutraceutical, it has been proven to be effective in regulating DM patient blood glucose levels. 9 Other than prescribed medications, taking this particular BMP as an aid to regulate blood sugar has become common in Taiwan since its introduction. The phenomenon of the wide acceptance and sharp growth of this captioned product in the nutraceutical market triggered this research interest in exploring a scientific method.…”