Abstract:Tumors create an extracellular pH (pHe) barrier and form an isolated microenvironment roughly 0.5 pH units lower than physiological pH, while the intracellular pH (pHi) is maintained within 0.2 pH units of physiological levels. Reduced tumor pHi is associated with apoptosis, and lowered arterial and tissue pH are seen with heavy exercise.PURPOSETo determine the pHi response of MCF‐7 cells subjected to acidic environments. MCF‐7 cells loaded with BCECF, a pH indicator, were used to create a standard curve of fl… Show more
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