McCune Albright syndrome: A case report with review of literature

A case report of McCune–Albright syndrome with hepatic manifestations

“… 6 , 9 Reduction in pain and improvement of quality of life have been reported in children with MAS treated with pamidronate and vitamin D and calcium supplements. 11 , 24 In general, the previous cases and the present case show the wide range of phenotypic severity and the challenges of diagnosis and treatment in pediatric MAS. Abnormalities in liver cells may be directly due to a mutation in the GNAS gene and may be the only early diagnostic sign, especially if associated with endocrine hyperactivity.…”

“… 10 Patients should be examined periodically and long term for all endocrine disorders by specialists. 11 Recently, bisphosphonate therapy, combined with exercises to strengthen the muscles around the affected bones, reduces pain, prevents fractures, and removes lesions partially. 6 , 9 Reduction in pain and improvement of quality of life have been reported in children with MAS treated with pamidronate and vitamin D and calcium supplements.…”

“… 13 Considering the wide and unique range of clinical symptoms of MAS 5 , 8 , 9 and the effect of age at diagnosis on disease progression and prognosis, 7 reports of new cases aid in early recognition of diagnosis, faster onset of treatment, which may slow progression, and reduce morbidity and mortality. 11 Here, we report a sporadic case of MAS identified and reported in Imam Khomeini Hospital in Esfarayen, Iran.…”

“… 1 Child with MAS often experience a sudden onset of gonadotropin pseudo‐precocious puberty. 7 In addition, endocrine disorders such as hyperthyroidism (38%) 11 , 12 and adrenal involvement (<5%) are seen in MAS patients. 1 Recently, cases of hepatic‐biliary involvement (liver adenomas, inflammatory gallbladder adenomas, neonatal icterus, and hepatoblastoma), pancreatic involvement, and gastrointestinal neoplasia have been reported.…”

“…Recently, cases of hepatic‐biliary involvement (liver adenomas, inflammatory gallbladder adenomas, neonatal icterus, and hepatoblastoma), pancreatic involvement, and gastrointestinal neoplasia have been reported 13 . Considering the wide and unique range of clinical symptoms of MAS 5,8,9 and the effect of age at diagnosis on disease progression and prognosis, 7 reports of new cases aid in early recognition of diagnosis, faster onset of treatment, which may slow progression, and reduce morbidity and mortality 11 . Here, we report a sporadic case of MAS identified and reported in Imam Khomeini Hospital in Esfarayen, Iran.…”