MC1R regulates T regulatory cells differentiation through metabolic reprogramming to promote colon cancer
Shaoliang Zhu,
Mengjie Zou,
Chunxing Li
et al.
Abstract:Background
By 2021, colon cancer was a leading global cancer, with early detection improving outcomes but advanced cases still having poor prognosis. Therefore, understanding its molecular mechanisms is crucial for developing new preventive and therapeutic strategies.
Methods
In our study, we leveraged the TCGA database to assess MC1R expression in colon cancer and its link with patient prognosis. Further, employing mouse models and diverse experimental techniques, we investigated MC1R's impact on colon canc… Show more
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