MBOAT7 locus rs641738 variant predisposes to hepatocellular carcinoma in nonalcoholic fatty liver

Donati, Benedetta; Dongiovanni, Paola; Miele, Luca; Rosso, Chiara; Maier, S.; Petta, Salvatore; Meroni, Marica; Luca, Laura De; Grimaudo, Stefania; Romagnoli, Renato; Colli, Fabio; Craxı̀, Antonio; Grieco, Antonio; Bugianesi, Elisabetta; Soardo, Giorgio; Valenti, L.

doi:10.1016/j.dld.2015.12.029

Cited by 3 publications

(2 citation statements)

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“…In addition, the study of Kawaguchi (2018) provided data on NAFLD type 4 and NASH-HCC rather than HCC data, therefore, we could not extract sufficient data to estimate the association between rs641738 and HCC risk and excluded this study ( 19 ). The remaining four studies were excluded because they had imputed genotype data (n = 1) ( 20 ) or overlapped data (n = 3) ( 21 – 23 ). Finally, we included three eligible articles ( 8 – 10 ) and this study for the meta-analysis ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

MBOAT7-TMC4 rs641738 Is Not Associated With the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection

Wang

Liu

et al. 2021

Front. Oncol.

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ObjectiveA hot genetic variant, rs641738 within the membrane-bound O-acyltransferase domain containing 7(MBOAT7) and transmembrane channel-like 4 (TMC4), was recently reported to be associated with several liver diseases. However, the results remain controversial. Therefore, this study aimed to explore the role of MBOAT7-TMC4 rs641738 in the risk of hepatocellular carcinoma (HCC) and persistent hepatitis B virus (HBV) infection.MethodsWe first conducted a case-control study that included 779 HCC cases and 1412 cancer-free controls. Controls consisted of 678 persistent HBV carriers and 734 spontaneously recovered subjects. The gene variant rs641738 was genotyped using the MassARRAY platform. The results were analyzed in five genetic models using multivariate logistic regression analyses. Next, we performed a systematic review and meta-analysis to further explore the role of this variant in HCC risk.ResultsThe results suggested no association between MBOAT7-TMC4 rs641738 and HCC risk in most genetic models (all P > 0.05). Although a marginally significant association was observed in TT vs. CC (P = 0.037) and the recessive models (P = 0.044). The meta-analysis of 2135 HCC cases and 4388 controls supported that this variant was not related to HCC risk, even in the TT vs. CC and recessive models. We also determined that this variant did not influence persistent HBV infection.ConclusionOur work highlights that MBOAT7-TMC4 rs641738 is not associated with the risk of HCC or persistent HBV infection. This study provides some clues to identify the “truth” of potential disease-related genetic factors in the post-genome era.

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Section: Resultsmentioning

confidence: 99%

MBOAT7-TMC4 rs641738 Is Not Associated With the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection

Wang

Liu

et al. 2021

Front. Oncol.

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“…Initially, we got 87 records by searching PubMed, Embase and Web of Science, and excluded 79 records by title and abstract review. After assessing the full-text articles, we further excluded five studies due to deviation from HWE (n = 1)[9], insufficient data to estimate ORs (n = 1) [17], or having overlapped data (n = 3) [18][19][20]. Finally, we included three eligible articles [6-8] and this study for meta-analysis (Additional file 2).…”

Section: Meta-analysis Of the Association Between Mboat7-tmc4 Rs64173mentioning

confidence: 99%

Association of MBOAT7-TMC4 rs641738 with the risk of hepatocellular carcinoma and persistent infection of hepatitis B virus: a case-control study and meta-analysis

P¹,

Zhou²,

L³

et al. 2019

Preprint

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Background: Recent studies reported that a hot genetic variant, rs641738 within the membrane bound O-acyltransferase domain containing 7(MBOAT7) and transmembrane channel-like 4 (TMC4) , was associated with several liver diseases. However, results are still conflicting. We conducted this study to explore the role of MBOAT7-TMC4 rs641738 in the risk of hepatocellular carcinoma (HCC) and persistent hepatitis B virus (HBV) infection. Methods: We first performed a case-control study by including 779 HCC cases and 1412 cancer-free controls. Controls are consisted of 678 HBV persistent carriers and 734 spontaneously recovered subjects. Rs641738 was genotyped by MassARRAY platform. Results were analyzed by multivariate logistic regression analysis under five genetic models. Second, we conducted a systematic review and meta-analysis to further explore the role of this variant in HCC risk. Results: Results suggested no association between MBOAT7-TMC4 rs641738 and HCC risk in most genetic models (All P > 0.05), although a marginally significant association was observed in TT vs. CC ( P = 0.037) and recessive model ( P = 0.044). Further meta-analysis including 2135 HCC cases and 4388 controls supported that this variant was not related to HCC risk, even in the TT vs. CC and recessive models. Besides, we identified that this variant also had no influence on persistent HBV infection. Conclusion: Our work highlights that MBOAT7-TMC4 rs641738 is not associated with the risk of HCC or persistent HBV infection. This study provides some clues to identify the “truth” of potential disease-related genetic factors in the post-genome era.

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Genetik metabolischer und viraler Lebererkrankungen

2017

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MBOAT7 locus rs641738 variant predisposes to hepatocellular carcinoma in nonalcoholic fatty liver

Cited by 3 publications

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MBOAT7-TMC4 rs641738 Is Not Associated With the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection

MBOAT7-TMC4 rs641738 Is Not Associated With the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection

Association of MBOAT7-TMC4 rs641738 with the risk of hepatocellular carcinoma and persistent infection of hepatitis B virus: a case-control study and meta-analysis

Genetik metabolischer und viraler Lebererkrankungen

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