Mazindol-induced lithium toxicity.

Hendy, Moataz S.; Dove, A F; Arblaster, Paul

doi:10.1136/bmj.280.6215.684-a

Cited by 21 publications

(3 citation statements)

References 4 publications

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“…There was a 50% dropout rate mainly due to severe side effects like ataxia, dizzi ness, restlessness, and confusional states resulting from the lithium-carbamazepine combination [Ghose, 1978], Lithium may prolong the neuromus cular blockage of succinylcholine, pancuronium and décaméthonium [Borden et al, 1974;Hill and Wong, 1976;Hill et al, 1977]. This interac tion is probably due to the lithium substitution for sodium ions at nerve terminals thus impeding presynaptic transmission [Carasanos, 1979], Lith ium may also increase the hypothyroid effects of iodides [Shopsin et al, 1973] and Carbimazole [Hedley et al, 1978], Methyldopa [Byrd, 1975;Osanloo and Deglin, 1980] and mazindol [Hendy et al, 1980] were reported to increase the risk of lithium toxicity and hydroxyzine may increase lith ium effects on cardiac repolarization [Hollister, 1975], Lithium can also decrease the pressor response to norepinephrine [Fann et al, 1972] and may attenuate the central nervous system stimulant, euphoric and systolic blood pressure increases of amphetamines [Angrist and Gershon, 1979].…”

Section: Lithium Drug Interactionsmentioning

confidence: 99%

Drug Interactions in Psychiatric Practice

Ragheb¹

1981

Int Pharmacopsychiatry

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The interaction of neuroleptics, tricyclic antidepressants, monoamine oxidase inhibitors, lithium and anxiolytic sedatives with other drugs and food is reviewed with special emphasis on drug interactions commonly encountered in psychiatric practice. Clinical relevance and mechanism of action of such interactions are discussed. An update of the interaction of lithium with prostaglandin inhibitors is presented.

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Section: Lithium Drug Interactionsmentioning

confidence: 99%

Drug Interactions in Psychiatric Practice

Ragheb¹

1981

Int Pharmacopsychiatry

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“…), mazindol(29), amitriptilin(32)(33), aspirin, verapamil(33), valproat(31), eritromisin, diüretikler, β blokerler, diklofenaktır(32). Antipsikotilerin özellikle de fenotiazinlerin lit-yumun eritrositlere girişini arttırdığı gösterilmiş olup, lityumla birlikte kullanılan antipsikotiklerle oluşan nörotoksik etkiden bu mekanizmanın sorumlu olduğu düşünülmektedir.…”

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Neurological side effects of lithium

Özdin¹,

Sarısoy²

2013

JMOOD

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Lityumun nörolojik yan etkileri Lityum 1940'lı yılların sonuna doğru Avustralya'lı bilim adamı John Cade'in çalışmaları sonucunda iki uçlu mizaç bozukluğunda yaygın olarak kullanılmaya başlanmıştır. Terapötik aralığının dar olması kullanımını kısıtlasa da iki uçlu bozukluk tedavisinde en önemli ilaçlardan biridir. Terapötik aralığının dar olmasından dolayı lityum zehirlenmesine sık rastlanır. Lityum kullanımı ile midebarsak, kalp-damar, dermatolojik, endokrinolojik ve sinir sistemlerini ilgilendiren birçok yan etki gelişebilmektedir. Gerek zehirlenmede gerekse normal serum düzeylerinde sinir sistemi ile ilgili yan etkilere sıklıkla rastlanmaktadır. Sinir sistemi ile ilgili yan etkiler lityum tedavisinin nadir olmayan, ancak en az tanınan yan etkilerindendir. Merkezi sinir sistemi ile ilgili yan etkiler hastanın ilaca uyumu konusunda önemli bir sorun teşkil etmektedir. Bu derlemenin amacı lityum kullanımı ya da zehirlenmesine bağlı ortaya çıkan sık ve az görülen nörolojik yan etkilerin gözden geçirilmesidir.

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“…The data on this interac tion is limited. Some patients taking this drug may develop lithium toxicity with increased lithium level [194][195][196]. O'Reagan [159] re ported a case of lithium toxicity related to the combined administration of the two drugs.…”

Section: Sympalhomimeticsmentioning

confidence: 99%

Psychotropic and Medical Drug Interactions

Ananth

Johnson

1992

Psychother Psychosom

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In a number of situations, drugs used to treat psychiatric and physical illnesses are coadministered to patients suffering primarily from a psychiatric illness. Hence, coadministration of medical and psychiatric drugs is not uncommon. With increasing use of multiple drugs, our ability to treat a number of disorders has increased, but simultaneously, the problem of drug interactions has also assumed importance. A number of factors contribute to such drug interactions in psychiatric patients. All these interactions are both pharmacologically and genetically determined. Genetic susceptibility is not practical to determine. It is therefore essential for the physician to employ drug combinations only when necessary, be aware of the known clinically significant interactions, anticipate and watch for them, avoid dangerous combinations, and monitor the patients receiving combination of drugs with vigilance.

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Mazindol-induced lithium toxicity.

Cited by 21 publications

References 4 publications

Drug Interactions in Psychiatric Practice

Drug Interactions in Psychiatric Practice

Neurological side effects of lithium

Psychotropic and Medical Drug Interactions

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