Maybe Now is the Time to Lift the Ban on Silicone Breast Implants

Sims, Suzanne; Lundberg, George D.

doi:10.1097/00006527-200222020-00004

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“…As a result of these risks, the Food and Drug Administration (FDA) declared a moratorium on silicone breast implant use in 1992 [ 6 , 7 , 8 ]. However, there has been conflicting and inconclusive evidence calling into question the association of silicone implants with these conditions, particularly a study from the Institute of Medicine in 1999 that stated there was no evidence that implants caused any significant clinical conditions [ 7 , 8 ].…”

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confidence: 99%

Removal of a Silicone Gel Breast Implant in a Multiple Myeloma Patient Improved Disease Status: A Case Report

et al. 2020

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A 52-year-old African-American woman with a prior history of monoclonal gammopathy of undetermined significance (MGUS) developed infiltrating ductal carcinoma of the left breast. Following a mastectomy, she underwent reconstruction with a silicone gel breast implant. Three years later, her MGUS had progressed to active multiple myeloma (MM). She had a minimal response after two different regimens of bortezomib-based treatments and monthly zoledronic acid, and was placed on maintenance therapy with bortezomib, intravenous dexamethasone, and oral methylprednisolone, as well as ongoing monthly zoledronic acid. After 1 year of this maintenance therapy, during which her myeloma markers remained unchanged, she had her silicone implant replaced with saline. Despite no change in her myeloma treatment, her laboratory values began to steadily improve following removal of the silicone implant. Her M-protein decreased from 2.14 to 0.83 g/dL and her IgG levels from 3,330 to 1,210 mg/dL following replacement of her silicone implant with saline. To our knowledge, this is the first report in which removal of silicone implants improved the clinical status of a patient with MM following a year of maintenance therapy during which the patient’s myeloma laboratory values remained unchanged. Further studies are warranted to determine if silicone breast implant removal can, in fact, improve MM patients’ disease status.

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