Mayaro virus infection in French Guiana, a cross sectional study 2003–2019

Mutricy, Rémi; Matheus, Séverine; Mosnier, Émilie; Martinez-Lorenzi, Enguerrane; Laval, Franck de; Niemetzky, F; Naudion, Pauline; Djossou, Félix; Rousset, Dominique; Epelboin, Loïc

doi:10.1016/j.meegid.2022.105243

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…Cell lines were incubated at 37 °C under a 5% CO2 atmosphere. The natural compounds Sanguinarine chloride (13-methyl-[1,3]-benzodioxolo[5,6- c ]-1,3-dioxolo[4,5- i ]phenanthridinium chloride), (97.8% purity); (R)-Shikonin (5,8-dihydroxy-2-[(1 R )-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione), (99.8% purity); Fisetin (2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4 H -1-benzopyran-4-one), (98.0% purity); Honokiol (5,3’-Diallyl-2,4’-dihydroxybiphenyl), (99.9% purity); Tanshinone IIA (6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2- b ]furan-10,11-dione), (98.6% purity); and α-Mangostin (1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9 H -xanthen-9-one), (97.7% purity), were obtained from Tocris (Minneapolis, MN, USA). All compounds were dissolved in Dimethyl sulfoxide (DMSO, Sigma-Aldrich, St. Louis, MI, USA) at 10 mM concentration and stored at −20 °C until use.…”

Section: Methodsmentioning

confidence: 99%

“…Arthropod-borne viruses (arboviruses) have provoked large epidemics in the Americas, including those of the Chikungunya (CHIKV) and Zika (ZIKV) viruses in 2013 and 2015, respectively [1,2]. Endemic and emerging arboviruses, such as Mayaro virus (MAYV), show increasing activity across the region [3][4][5][6][7]. MAYV is a neglected arbovirus belonging to the Togaviridae family within the Alfavirus genus [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway

Valdes-Torres

Campos

Bhakta

et al. 2022

Preprint

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Mayaro virus (MAYV) is an emerging arbovirus with increasing circulation across the Americas. In the present study, we evaluated the potential antiviral activity of the following natural com-pounds against MAYV and other arboviruses: Sanguinarine, (R)-Shikonin, Fisetin, Honokiol, Tanshinone IIA and alfa-Mangostin. Sanguinarine and Shikonin showed significant cytotoxicity, whereas Fisetin, Honokiol, Tanshinone IIA and alfa-Mangostin were well-tolerated in all the cell lines tested. Honokiol and alfa-Mangostin treatment protected Vero-E6 cells against MAYV-induced damage and resulted in a dose-dependent reduction in viral progeny yields for each of the MAYV strains and human cell lines assessed. Also, Honokiol and alfa-Mangostin disrupted MAYV infection at different stages of the virus life cycle. Moreover, these compounds de-creased Una, Chikungunya and Zika viral titers and downmodulated the expression of E1 and nsP1 viral proteins from MAYV, Una and Chikungunya. Finally, in Honokiol- and alfa-Mangostin-treated cells, we observed an upregulation in the expression of type I interferon and specific interferon-stimulated genes, including IFN-alfa, IFN-beta;, MxA, ISG15, OAS2, MDA-5, TNF-alfa and IL-1beta;, which may promote an antiviral cellular state. Our results indicate that Honokiol and alfa-Mangostin present potential broad-spectrum activity against different arboviruses through a possible modulation of the interferon pathway.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway

Valdes-Torres

Campos

Bhakta

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…MAYV is more frequently detected in other countries, in addition to Trinidad and Tobago, Brazil, and Peru. It has also been identified in Panama, French Guiana, Colombia, Argentina, Venezuela, and Paraguay [49,50]. Studies have reported MAYV positivity in wild mammals, birds, or reptiles, as well as in domestic animals.…”

Section: Mayaro (Mayv)mentioning

confidence: 99%

Neglected Arboviruses in Latin America

Rodríguez‐Morales¹,

Bonilla-Aldana²

2023

New Advances in Neglected Tropical Diseases

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Over the last decade, there has been an increasing concern for epidemics in Latin America, as well as in other regions, due to arboviruses causing epidemics. Before 2013, dengue and yellow fever were of major preoccupation in urban and rural areas, respectively. But after that year, the emergence of chikungunya (2013) and Zika (2015) with their widespread in the region, affected millions of individuals, especially in tropical countries. Nowadays, other alpha and flaviviruses, but also bunyaviruses, have been circulating in the region causing small outbreaks, as is the case of Mayaro, Madariaga, Rocio, Oropouche, and St. Louis encephalitis, among others. In the current chapter, we address the situation regarding these other arboviruses that have been neglected by also being a differential diagnosis and an etiology of febrile syndrome in the region.

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“…Arthropod-borne viruses (arboviruses) have provoked large epidemics in the Americas, including the Chikungunya (CHIKV) and Zika (ZIKV) viruses in 2013 and 2015, respectively [ 1 , 2 ]. Endemic and emerging arboviruses, such as Mayaro virus (MAYV), show increasing activity across the region [ 3 , 4 , 5 , 6 , 7 ]. MAYV is a neglected arbovirus belonging to the Togaviridae family within the Alphavirus genus [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Honokiol and Alpha-Mangostin Inhibit Mayaro Virus Replication through Different Mechanisms

et al. 2022

View full text Add to dashboard Cite

Mayaro virus (MAYV) is an emerging arbovirus with an increasing circulation across the Americas. In the present study, we evaluated the potential antiviral activity of the following natural compounds against MAYV and other arboviruses: Sanguinarine, (R)-Shikonin, Fisetin, Honokiol, Tanshinone IIA, and α-Mangostin. Sanguinarine and Shikonin showed significant cytotoxicity, whereas Fisetin, Honokiol, Tanshinone IIA, and α-Mangostin were well tolerated in all the cell lines tested. Honokiol and α-Mangostin treatment protected Vero-E6 cells against MAYV-induced damage and resulted in a dose-dependent reduction in viral progeny yields for each of the MAYV strains and human cell lines assessed. These compounds also reduced MAYV viral RNA replication in HeLa cells. In addition, Honokiol and α-Mangostin disrupted MAYV infection at different stages of the virus life cycle. Moreover, Honokiol and α-Mangostin decreased Una, Chikungunya, and Zika viral titers and downmodulated the expression of E1 and nsP1 viral proteins from MAYV, Una, and Chikungunya. Finally, in Honokiol- and α-Mangostin-treated HeLa cells, we observed an upregulation in the expression of type I interferon and specific interferon-stimulated genes, including IFNα, IFNβ, MxA, ISG15, OAS2, MDA-5, TNFα, and IL-1β, which may promote an antiviral cellular state. Our results indicate that Honokiol and α-Mangostin present potential broad-spectrum activity against different arboviruses through different mechanisms.

show abstract

Mayaro virus infection in French Guiana, a cross sectional study 2003–2019

Cited by 10 publications

References 22 publications

Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway

Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway

Neglected Arboviruses in Latin America

Honokiol and Alpha-Mangostin Inhibit Mayaro Virus Replication through Different Mechanisms

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