Mayaro Virus: A New Human Disease Agent

Anderson, Charles R.; Downs, W. G.; Wattley, George H; Ahin, Norman W.; Reese, Alick A.

doi:10.4269/ajtmh.1957.6.1012

Cited by 200 publications

(95 citation statements)

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“…Although mosquitoes of the genus Haemagogus are presumed to be the principal vector of the virus, experimental studies indicate that MAYV can also infect and be transmitted by Aedes aegypti 1 . So potentially, it might be transmitted in urban areas under the appropriate conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The first isolations of MAYV were made from blood of five febrile forest workers in Trinidad in 1954 1 . The virus has been responsible for epidemics in South America and has been recovered from humans, wild vertebrates and mosquitoes in Brazil, Bolivia, Colombia, French Guiana, Guyana, Peru and Surinam 16,18 .…”

Section: Mayaro Virus (Mayv) Is An Arbovirus Member Of the Genusmentioning

confidence: 99%

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Mayaro virus: imported cases of human infection in São Paulo State, Brazil

Coimbra

Santos

Suzuki

et al. 2007

Rev. Inst. Med. trop. S. Paulo

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SUMMARYMayaro virus (MAYV) is an arbovirus (Togaviridae: Alphavirus) enzootic in tropical South America and maintained in a sylvan cycle involving wild vertebrates and Haemagogus mosquitoes. MAYV cases occur sporadically in persons with a history of recent activities inside or around forests. This paper reports three cases of MAYV fever detected in men infected in Camapuã, MS, Brazil. Serum samples collected at four days and two months after the onset of the symptoms and examined by hemagglutination inhibition test, revealed monotypic seroconversion to MAYV. Isolation of the virus was obtained from one of the samples by inoculation of the first blood samples into newborn mice. A suspension of the infected mouse brain was inoculated into C6/36 cells culture and the virus was identified by indirect immunofluorescent assay with alphavirus polyclonal antibodies. RT-PCR, performed with RNA extracted from the supernatant of C6/36 infected cells in the presence of alphavirus generic primers as well as specific MAYV primers, confirmed these results. The reported cases illustrate the importance of laboratory confirmation in establishing a correct diagnosis. Clinical symptoms are not always indicative of a disease caused by an arbovirus. Also MAYV causes febrile illness, which may be mistaken for dengue.

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Section: Discussionmentioning

confidence: 99%

Section: Mayaro Virus (Mayv) Is An Arbovirus Member Of the Genusmentioning

confidence: 99%

Mayaro virus: imported cases of human infection in São Paulo State, Brazil

Coimbra

Santos

Suzuki

et al. 2007

Rev. Inst. Med. trop. S. Paulo

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“…This virus was first isolated during an outbreak in a rural community 120 miles east of the city of Belem, Brazil. Clinical manifestations of Mayaro virus infection in humans were described as a feverish illness accompanied by headache, epigastric pain, backache, chills, nausea and photophobia [2,6].…”

Section: Introductionmentioning

confidence: 99%

Replication of Mayaro virus in Aedes albopictus cells: an electron microscopic study

Mezêncio

Souza

Fonseca

et al. 1989

Archives of Virology

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The replication of Mayaro virus in Aedes albopictus cells, was studied by electron microscopy at various times post-infection. In infected cells we observed the presence of cytoplasmic vesicles containing viral nucleocapsids and mature virus particles but at no time did we detect virus budding into such vacuoles. Budding of virus through plasma membrane was rarely observed. Our results are discussed considering the possibility of the release of virus particles to the extracellular space by exocytosis.

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“…It is interesting to note a greater percentage of positive reactions to horse antibody HI (8.36%) and water buffalo (7.49%). 29 and is frequently isolated in northern of South America from humans, wild vertebrates (mainly monkeys) and mosquitoes. Outbreaks in humas caused by the virus of that febrile exanthematous disease have been frequently reported in Amazonia 11,30,31 .…”

Section: Discussionmentioning

confidence: 99%

Alphavirus serosurvey in domestic herbivores in Pará State, Brazilian Amazon

Casseb

Chiang²,

Martins³

et al. 2012

Rev Pan-Amaz Saude

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Pará State comprises 26% of Brazilian Amazon Region where a large diversity of arboviruses has been described. This study aimed to assess the prevalence and distribution of hemagglutination-inhibition (HI) that detect antibodies against four units to Eastern equine encephalitis virus (EEEV), Western equine encephalitis virus (WEEV), Mayaro virus (MAYV) and Mucambo virus (MUCV), a subtype of the Venezuelan equine encephalitis virus (VEEV), in 2,191 serum samples of horses, cattle, sheep and water buffaloes in Pará State, Brazil. The goal was to identify the prevalence of antibodies in these domestic farm animals to determine which arboviruses are circulating and determine which farm animal is the most sensitive for detecting Alphavirus. Antibodies against all investigated arboviruses were detected in almost all animals species studied. Our results indicated that domestic herbivores are susceptible to the tested arboviruses and evidence of active Alphavirus in farm animals in the Brazilian Amazon. An analysis of HI antibody prevalence by animal species indicated significant difference between horses and water buffaloes, cattle and sheep. The horses showed higher prevalence of antibodies in heterotypic reactions showing to be the best species of domestic farm animal to serve as sentinel to detect the movement of arboviruses in the Brazilian Amazon.

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Mayaro Virus: A New Human Disease Agent

Cited by 200 publications

References 0 publications

Mayaro virus: imported cases of human infection in São Paulo State, Brazil

Mayaro virus: imported cases of human infection in São Paulo State, Brazil

Replication of Mayaro virus in Aedes albopictus cells: an electron microscopic study

Alphavirus serosurvey in domestic herbivores in Pará State, Brazilian Amazon

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