Mayaro as a Caribbean traveler: Evidence for multiple introductions and transmission of the virus into Haiti

Blohm, Gabriela M.; Elbadry, Maha A.; Mavian, Carla; Stephenson, Caroline J.; Loeb, Julia C.; White, Sarah K.; Telisma, Taina; Chavannes, Sonese; Rochar, Valerie Madsen Beau De; Salemi, Marco; Lednicky, John A.; Morris, J. Glenn

doi:10.1016/j.ijid.2019.07.031

Cited by 35 publications

(27 citation statements)

References 15 publications

(38 reference statements)

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“…As expected, our analysis suggests a Caribbean origin for the Manatee County isolate due to movements of DENV4 into Florida from Haiti and, preceding that, into Haiti from Puerto Rico. These results agree with previous findings depicting the Caribbean as a hot spot for arboviral spread in the Americas (18)(19)(20). Diversifying selective pressure in the NS2A gene and the 2K peptide ( Fig.…”

Section: Discussionsupporting

confidence: 93%

Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes

Boyles

Mavian

Finol

et al. 2020

mSphere

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The incidence of locally acquired dengue infections increased during the last decade in the United States, compelling a sustained research effort concerning the dengue mosquito vector, Aedes aegypti, and its microbiome, which has been shown to influence virus transmission success. We examined the "metavirome" of four populations of Aedes aegypti mosquitoes collected in 2016 to 2017 in Manatee County, FL. Unexpectedly, we discovered that dengue virus serotype 4 (DENV4) was circulating in these mosquito populations, representing the first documented case of such a phenomenon in the absence of a local DENV4 human case in this county over a 2-year period. We confirmed that all of the mosquito populations carried the same DENV4 strain, assembled its full genome, validated infection orthogonally by reverse transcriptase PCR, traced the virus origin, estimated the time period of its introduction to the Caribbean region, and explored the viral genetic signatures and mosquito-specific virome associations that potentially mediated DENV4 persistence in mosquitoes. We discuss the significance of prolonged maintenance of the DENV4 infections in A. aegypti that occurred in the absence of a DENV4 human index case in Manatee County with respect to the inability of current surveillance paradigms to detect mosquito vector infections prior to a potential local outbreak. IMPORTANCE Since 1999, dengue outbreaks in the continental United States involving local transmission have occurred only episodically and only in Florida and Texas. In Florida, these episodes appear to be coincident with increased introductions of dengue virus into the region through human travel and migration from countries where the disease is endemic. To date, the U.S. public health response to dengue outbreaks has been largely reactive, and implementation of comprehensive arbovirus surveillance in advance of predictable transmission seasons, which would enable proactive preventative efforts, remains unsupported. The significance of our finding is that it is the first documented report of DENV4 transmission to and maintenance within a local mosquito vector population in the continental United States in the ab-

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Section: Discussionsupporting

confidence: 93%

Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes

Boyles

Mavian

Finol

et al. 2020

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“…In our study, we observed an epidemiological link between Zika outbreaks in Haiti and the southwest region of the Dominincan Republic. This connection likely extends to other mosquito-borne viruses such as Mayaro virus and West Nile virus, which have been reported in Haiti [58][59][60] . The former can be transmitted by Aedes mosquitoes 14,[61][62][63] , and the latter has been isolated from zoonotic reservoirs in the Dominican Republic 64 .…”

Section: Discussionmentioning

confidence: 53%

Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic

Earnest

Lourenço

et al. 2021

Nat Commun

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Mosquito-borne viruses threaten the Caribbean due to the region’s tropical climate and seasonal reception of international tourists. Outbreaks of chikungunya and Zika have demonstrated the rapidity with which these viruses can spread. Concurrently, dengue fever cases have climbed over the past decade. Sustainable disease control measures are urgently needed to quell virus transmission and prevent future outbreaks. Here, to improve upon current control methods, we analyze temporal and spatial patterns of chikungunya, Zika, and dengue outbreaks reported in the Dominican Republic between 2012 and 2018. The viruses that cause these outbreaks are transmitted by Aedes mosquitoes, which are sensitive to seasonal climatological variability. We evaluate whether climate and the spatio-temporal dynamics of dengue outbreaks could explain patterns of emerging disease outbreaks. We find that emerging disease outbreaks were robust to the climatological and spatio-temporal constraints defining seasonal dengue outbreak dynamics, indicating that constant surveillance is required to prevent future health crises.

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“…The analysis showed that the MAYV isolate diverged about 100 years ago from the 2010 Venezuelan isolates, with the time of the MRCA (tMRCA) dating back to 1914 (with a 95% high posterior density (HPD) interval of 1883-1936). The tMRCA for the 2016 MAYV isolate and the most closely related MAYV isolates to this isolate (DQ001069, isolated in 1999 in French Guiana, and MK837006 and MK837007, isolated in 2014 in Haiti 29 ) was more recent, dating back to 1980 (with a 95% HPD interval of 1971-1988). The tMRCA for subsequent divergence of the lineages leading to the French Guiana strain and the Haitian strains dated to 1996.…”

Section: Resultsmentioning

confidence: 96%

Isolation of Mayaro Virus from a Venezuelan Patient with Febrile Illness, Arthralgias, and Rash: Further Evidence of Regional Strain Circulation and Possible Long-Term Endemicity

Blohm

Márquez-Colmenarez

Lednicky

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Fifty-two febrile patients living in Barquisimeto, Venezuela, were screened for arbovirus infection by virus culture during an outbreak of what was thought to be Zika virus infection. We report identification of Mayaro virus (MAYV) on culture of plasma from one patient, an 18-year-old woman with acute febrile illness, arthralgias, and psoriasiform rash. The strain was sequenced and was found to be most closely related to a 1999 strain from French Guiana, which, in turn, was related to two 2014 strains from Haiti. By contrast, previously reported outbreak-related MAYV strains from a sylvatic area approximately 80 miles from where the case patient lived were most closely related to Peruvian isolates. The two strain groups show evidence of having diverged genetically approximately 100 years ago.

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Mayaro as a Caribbean traveler: Evidence for multiple introductions and transmission of the virus into Haiti

Cited by 35 publications

References 15 publications

Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes

Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes

Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic

Isolation of Mayaro Virus from a Venezuelan Patient with Febrile Illness, Arthralgias, and Rash: Further Evidence of Regional Strain Circulation and Possible Long-Term Endemicity

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