May one-stage exchange for Candida albicans peri-prosthetic infection be successful?

Jenny, Jean–Yves; Goukodadja, Oswald; Boéri, Cyril; Gaudias, J.

doi:10.1016/j.otsr.2015.10.001

Cited by 18 publications

(12 citation statements)

References 15 publications

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“…From the patients treated with resection arthroplasty, one dead after fluconazole treatment 34, two suffered amputation 14, 23 and two were found to have a bacterial infection 26, 56. All three patients treated with one-stage exchange arthroplasty cured 40, 45. Our two patients are currently well with antifungal treatment only, and no relapse of disease has been observed in the short follow-up.…”

Section: Literature Reviewmentioning

confidence: 67%

“…Moreover, some authors have recently reported favourable outcome after one-stage exchange in selected cases of fungal PJI 45, 74. In these cases, the responsible microorganism was identified post-operatively, with delayed specific antifungal treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The mean age of patients was 65.7 (± SD 18) yrs (range 35-93 yrs). Thirty-five cases were from the USA 10-33, 10 from Taiwan 34-36, six from the United Kingdom 37-41, six from Germany 42, four from France 43-45, three from Italy 46-48, two each from Japan 49, 50 and Spain [9, and present report], and one each from China 51, India 52, Slovenia 53, Belgium 54, Turkey 55, Canada 56, Malaysia 57 and Sweden 58. No risk factors for candidal infection were found in 25 patients (32.8%).…”

Section: Literature Reviewmentioning

confidence: 99%

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Candida Prosthetic Joint Infection. A Review of Treatment Methods

Cobo

Rodríguez‐Grangér

Sampedro

et al. 2017

J. Bone Joint Infect.

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Fungal microorganisms are still a rare cause of bone and joint infections. We report a new case of knee prosthetic joint infection due to Candida albicans in a patient with a previous two-stage right knee arthroplasty for septic arthritis due to S. epidermidis occurred several months ago. Moreover, the treatment in 76 cases of Candida prosthetic joint infection has been discussed. Forty patients were female and mean age at diagnosis was 65.7 (± SD 18) yrs. No risk factors for candidal infection were found in 25 patients. Infection site was the knee in 38 patients and hip in 36; pain was present in 44 patients and swelling in 24. The most frequent species was C. albicans, followed by C. parapsilosis. Eleven patients were only treated with antifungal drugs being the outcome favourable in all of them. Two-stage exchange arthroplasty was performed in 30 patients, and resection arthroplasty in other 30; in three patients one-stage exchange arthroplasty was done. A favourable outcome was found in 58 patients after antifungal plus surgical treatment, in 11 after antifungal treatment alone and in one after surgery alone. The type of treatment is still not clearly defined and an algorithm for treatment in fungal PJI should be established, but various types of surgical procedures may be applied.

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Section: Literature Reviewmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Candida Prosthetic Joint Infection. A Review of Treatment Methods

Cobo

Rodríguez‐Grangér

Sampedro

et al. 2017

J. Bone Joint Infect.

View full text Add to dashboard Cite

show abstract

“…Esta indicação é baseada em relatos e séries de casos e opinião de especialistas. Relatos de remissão clínica com a limpeza cirúrgica e retenção do implante (16,45,47,48,61) , com a revisão em um tempo (46,59,68,70) e até com tratamento conservador sem abordagem cirúrgica (16,43) já foram publicados.…”

Section: Discussão Dos Resultados Da Série De Casosunclassified

“…foi utilizado em inúmeros casos. (16,19,31,34,37,40,42,46,49,51,56,57,60,68,70) . A revisão dos casos realizada neste trabalho não encontrou benefício nesta prática e a associação de antifúngicos não é mencionada como possibilidade terapêutica nos principais Guidelines que versam sobre infecção em prótese articular (21,28,29) .…”

Section: Discussão Dos Resultados Da Série De Casosunclassified