May interstellar leucine react with NO radicals present in interstellar/interplanetary medium? An ion-trap mass spectrometry study

Zins, Emilie‐Laure; Pirim, Claire; Vettier, Ludovic; Chaboud, M.; Krim, Lahouari

doi:10.1016/j.ijms.2013.04.026

Cited by 2 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have used fragmentation to reveal possible biomolecule synthesis routes. 30,31 respectively, agree well with calculated values for our predicted structures of these ions. Further fragmentation results also support our structural identifications.…”

Section: Discussionsupporting

confidence: 88%

“…29 Biomolecule dissociation is vital to the prediction of prebiotic formation routes. 30,31 The reactivity of biomolecule fragments is also essential to this end. In this study, we expand our previous work on the interstellar formation pathways, 32,33 reactivity, 34 and fragmentation 35 of complex interstellar organics through an analysis of uracil and its anionic derivatives.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anionic derivatives of uracil: fragmentation and reactivity

Cole

Wang

Snow

et al. 2014

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

Uracil is an essential biomolecule for terrestrial life, yet its prebiotic formation mechanisms have proven elusive for decades. Meteorites have been shown to contain uracil and the interstellar abundance of aromatic species and nitrogen-containing molecules is well established, providing support for uracil's presence in the interstellar medium (ISM). The ion chemistry of uracil may provide clues to its prebiotic synthesis and role in the origin of life. The fragmentation of biomolecules provides valuable insights into their formation. Previous research focused primarily on the fragmentation and reactivity of cations derived from uracil. In this study, we explore deprotonated uracil-5-carboxylic acid and its anionic fragments to elucidate novel reagents of uracil formation and to characterize the reactivity of uracil's anionic derivatives. The structures of these fragments are identified through theoretical calculations, further fragmentation, experimental acidity bracketing, and reactivity with several detected and potential interstellar species (SO2, OCS, CS2, NO, N2O, CO, NH3, O2, and C2H4). Fragmentation is achieved through collision induced dissociation (CID) in a commercial ion trap mass spectrometer, and all reaction rate constants are measured using a modification of this instrument. Experimental data are supported by theoretical calculations at the B3LYP/6-311++G(d,p) level of theory. Lastly, the astrochemical implications of the observed fragmentation and reaction processes are discussed.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Anionic derivatives of uracil: fragmentation and reactivity

Cole

Wang

Snow

et al. 2014

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

show abstract

“…Another strategy to illuminate biomolecule formation is to analyze it in reverse. Tandem mass spectrometry involving collision-induced dissociation (CID) paired with theoretical calculations can reveal underlying mechanisms and important precursor molecules to specific syntheses. , The CID processes of protonated purines − and purine cations have been thoroughly explored. Other purine fragmentation experiments have focused on electron, , photon, ion, , and atom bombardment to achieve molecular dissociation.…”

Section: Introductionmentioning

confidence: 99%

Deprotonated Purine Dissociation: Experiments, Computations, and Astrobiological Implications

Cole

Wang

Snow³

et al. 2015

J. Phys. Chem. A

View full text Add to dashboard Cite

A central focus of astrobiology is the determination of abiotic formation routes to important biomolecules. The dissociation mechanisms of these molecules lend valuable insights into their synthesis pathways. Because of the detection of organic anions in the interstellar medium (ISM), it is imperative to study their role in these syntheses. This work aims to experimentally and computationally examine deprotonated adenine and guanine dissociation in an effort to illuminate potential anionic precursors to purine formation. Collision-induced dissociation (CID) products and their branching fractions are experimentally measured using an ion trap mass spectrometer. Deprotonated guanine dissociates primarily by deammoniation (97%) with minor losses of carbodiimide (HNCNH) and/or cyanamide (NH2CN), and isocyanic acid (HNCO). Deprotonated adenine fragments by loss of hydrogen cyanide and/or isocyanide (HCN/HNC; 90%) and carbodiimide (HNCNH) and/or cyanamide (NH2CN; 10%). Tandem mass spectrometry (MS(n)) experiments reveal that deprotonated guanine fragments lose additional HCN and CO, while deprotonated adenine fragments successively lose HNC and HCN. Every neutral fragment observed in this study has been detected in the ISM, highlighting the potential for nucleobases such as these to form in such environments. Lastly, the acidity of abundant fragment ions is experimentally bracketed. Theoretical calculations at the B3LYP/6-311++G(d,p) level of theory are performed to delineate the mechanisms of dissociation and analyze the energies of reactants, intermediates, transition states, and products of these CID processes.

show abstract

May interstellar leucine react with NO radicals present in interstellar/interplanetary medium? An ion-trap mass spectrometry study

Cited by 2 publications

References 34 publications

Anionic derivatives of uracil: fragmentation and reactivity

Anionic derivatives of uracil: fragmentation and reactivity

Deprotonated Purine Dissociation: Experiments, Computations, and Astrobiological Implications

Contact Info

Product

Resources

About