maxPET, a dedicated mammary and axillary region PET imaging system for breast cancer

Doshi, N.; Silverman, Robert W.; Shao, Yiping; Cherry, Simon R.

doi:10.1109/23.940168

Cited by 70 publications

(30 citation statements)

References 11 publications

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“…Averaging of X uivj for LORs between modules is permitted as inter detector dead space is minimized via optical fiber bundles 29 and a crystal pitch of 3.3 mm is assumed throughout the whole PET head. The product of detector efficiencies (e ui e vj ) are estimated from a high count experimental acquisition of a uniformly filled plane source for the detector heads at a single angular position parallel to the source.…”

Section: Iib2 Normalizationmentioning

confidence: 99%

Quantification with a dedicated breast PET/CT scanner

2012

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Purpose: Dedicated breast PET/CT is expected to have utility in local staging, surgical planning, monitoring of therapy response, and detection of residual disease for breast cancer. Quantitative metrics will be integral to several such applications. The authors present a validation of fully 3D data correction schemes for a custom built dedicated breast PET/CT (DbPET/CT) scanner via 18 F-FDG phantom scans. Methods: A component-based normalization was implemented, live-time was estimated with a multicomponent model, and a variance reduced randoms estimate was computed from delayed coincidences. Attenuation factors were calculated by using a CT based segmentation scheme while scatter was computed using a Monte Carlo (MC) simulation method. As no performance standard currently exists for breast PET systems, custom performance tests were created based on prior patient imaging results. Count-rate linearity for live-time and randoms corrections was measured with a decay experiment for a solid polyethylene cylinder phantom with an offset line source. A MC simulation was used to validate attenuation correction, a multicompartment phantom with asymmetric activity distribution provided an assessment of scatter correction, and image uniformity after geometric and detector normalization was measured from a high count scan of a uniform cylinder phantom. Raw data were reconstructed with filtered back projection (FBP) after Fourier rebinning. To quantify performance absolute activity concentrations, contrast recovery coefficients and image uniformity were calculated through region of interest analysis. Results: The most significant source of error was attributed to mispositioning of events due to pileup, presenting in count-related axial and transaxial nonuniformities that were not corrected for with the normalization method used here. Within the range of singles counts observed during clinical trials residual error after applying all corrections was comparable to that of a commercial whole body PET/CT system. Conclusions: The results suggest that DbPET/CT is capable of producing quantitative images under the operating conditions expected during patient imaging. V C 2012 American Association of Physicists in Medicine. [http://dx

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Section: Iib2 Normalizationmentioning

confidence: 99%

Quantification with a dedicated breast PET/CT scanner

2012

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“…The main limitation of X-ray mammographic methods is their low specificity (not differentiating between benign and malignant lesions). This requires one of several invasive techniques such as core biopsies or lumpectomy to be performed in order to determine the stage or malignancy of the disease [4,5]. Each of these techniques is economically and psychologically burdensome, especially if these exams demonstrate they were not necessary.…”

Section: Introductionmentioning

confidence: 99%

“…Positron Emission Tomography (PET), using [F-18] fluoro-deoxyglocose (FDG) as the tracer and whole-body clinical scanners, has been shown to be highly sensitive and specific in functional studies of breast cancer and may be a cost-effective alternative to invasive procedures under certain circumstances [4]. However, conventional WB-PET systems have several shortcomings for breast imaging related to the general purpose nature of these systems.…”

Section: Introductionmentioning

confidence: 99%

CYBPET: a cylindrical PET system for breast imaging

Karimian

Thompson

Sarkar

et al. 2005

Nuclear Instruments and Methods in Physics Research Section A:

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We propose a Cylindrical Breast PET (CYBPET) system for breast imaging with patients in the prone position. An individual pendulous breast is covered by thin plastic to provide reduced pressure fixation and surrounded by the crystals inside the CYBPET ring. Each breast is imaged separately. The rest of the body is shielded properly to minimize the contribution of scattered photons from the other breast and the rest of the body. To compare the CYBPET with whole-body PET (WB-PET) the simulations of CYBPET and a WB-PET (GE-Advance) for a 10 mm tumor inside the breast with a lesion to background (breast) activity concentration of 6 to 1 were made. The noise effective count rate (NECR) of CYBPET is about twice that of WB-PET at activity concentrations less than 3.1 mCi/cc. The spatial resolution of CYBPET is better by 25% than the WB-PET. r

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“…To reduce the dead area and cost, larger crystals can be mapped onto smaller photodetector-active areas with minimal loss in positioning accuracy. Methods to accomplish this include using devices to reflect light from crystals outside the active area into the active area (13), using optical fiber bundles (20) or tapered light-guides (14) to couple light from the crystal arrays onto detectors, or using monolithic crystals with a truncated pyramid structure to minimize the dead space between detector modules (2).…”

Section: Detector Design Issuesmentioning

confidence: 99%

Breast-Dedicated Radionuclide Imaging Systems

2016

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Breast-dedicated radionuclide imaging systems show promise for increasing clinical sensitivity for breast cancer while minimizing patient dose and cost. We present several breast-dedicated coincidencephoton and single-photon camera designs that have been described in the literature and examine their intrinsic performance, clinical relevance, and impact. Recent tracer development is mentioned, results from recent clinical tests are summarized, and potential areas for improvement are highlighted. Br east cancer is the most common cancer in women worldwide, with 1.3 million cases diagnosed per year. The current standard of care in breast cancer management has challenges. Physical examinations often find palpable tumors that are already invasive and node-positive. Mammograms are well known for having low specificity and often being inconclusive for patients with dense breasts, leading to unnecessary surgical procedures and patient trauma. The use of noninvasive molecular imaging provides sensitive and specific cellular biologic information to aid in the diagnosis, staging, and treatment evaluation of breast cancer. PET and single-photon emission imaging have shown great diagnostic power in detection of malignant lesions in the body. The conventional systems sitting in the nuclear medicine clinic, however, are generalpurpose and have neither the photon sensitivity nor the spatial resolution required to affect earlier stages of breast cancer management. Technologic advances have enabled the creation of high-performance breast-dedicated (BD) radionuclide cameras that show promise for more sensitive cancer detection than standard clinical cameras while also providing better specificity than traditional anatomic imaging modalities such as x-ray mammography. This paper presents novel instrumentation from several different BD system designs that have been studied and evaluates the performance of different BD systems in the clinic. BD POSITRON EMISSION MAMMOGRAPHY (PEM) AND PET CAMERA DESIGNSSystem Configuration BD PET requires a field of view (FOV) large enough to be clinically relevant for breasts of all sizes, ranging from an average of 11.1-13.7 cm in diameter and 5.7-9.7 cm in length for bra cup sizes A-D (1). Detectors are typically arranged in a ring around the breast (annular systems), or in panels on 2 sides (dual-panel systems) or 4 sides (rectangular systems) of the breast. Translatable (2,3) and rotatable (4-7) detector heads can be used to extend the imaging FOV beyond the detector volume, but to date have had lower sensitivities than stationary systems with equivalent FOVs, and require longer scan times and more complex mechanical designs. For example, the sensitivity of the Shimadzu O-ring system is a factor of 5 higher than that of the Oncovision MAMMI system, which has a similar imaging FOV but uses translating heads (Table 1). Higher photon sensitivity generally allows for shorter scan times to achieve equivalent image quality, as seen with imaging protocols used for stationary (8) and translating systems ...

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maxPET, a dedicated mammary and axillary region PET imaging system for breast cancer

Cited by 70 publications

References 11 publications

Quantification with a dedicated breast PET/CT scanner

Quantification with a dedicated breast PET/CT scanner

CYBPET: a cylindrical PET system for breast imaging

Breast-Dedicated Radionuclide Imaging Systems

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