Maximum Standardized Uptake Value of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Is a Prognostic Factor in Ovarian Clear Cell Adenocarcinoma

Konishi, Haruhisa; Takehara, Kazuhiro; Kojima, Atsumi; Okame, Shinichi; Yamamoto, Yorimasa; Shiroyama, Yuko; Yokoyama, Takashi; Nogawa, Takayoshi; Sugawara, Yumi

doi:10.1097/igc.0000000000000180

Cited by 35 publications

(63 citation statements)

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“…The SUV max has been suggested as a significant parameter for predicting clinical outcomes in EOC. However, SUV max is just a point measurement of highest metabolic activity and provides no additional information concerning tumor burden . Recently, several reports have suggested that volumetric parameters of 18 F‐FDG PET/CT, that is, MTV and TLG, comprehensively reflect both metabolic activity and tumor burden in a 3‐D way, and predict survival more accurately than SUV max in EOC .…”

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confidence: 99%

Metabolic tumor burden predicts prognosis of ovarian cancer patients who receive platinum‐based adjuvant chemotherapy

et al. 2016

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Volumetric parameters of positron emission tomography–computed tomography using 18F‐fludeoxyglucose (18F‐FDG PET/CT) that comprehensively reflect both metabolic activity and tumor burden are capable of predicting survival in several cancers. The aim of this study was to investigate the predictive performance of metabolic tumor burden measured by 18F‐FDG PET/CT in ovarian cancer patients who received platinum‐based adjuvant chemotherapy after cytoreductive surgery. Included in this study were 37 epithelial ovarian cancer patients. Metabolic tumor burden in terms of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), clinical stage, histological type, residual tumor after primary cytoreductive surgery, baseline serum carbohydrate antigen 125 (CA125) level, and the maximum standardized uptake value (SUVmax) were determined, and compared for their performance in predicting progression‐free survival (PFS). Metabolic tumor volume correlated with CA125 (r = 0.547, P < 0.001), and TLG correlated with SUVmax and CA125 (SUVmax, r = 0.437, P = 0.007; CA125, r = 0.593, P < 0.001). Kaplan–Meier analysis showed a significant difference in PFS between the groups categorized by TLG (P = 0.043; log–rank test). Univariate analysis indicated that TLG was a statistically significant risk factor for poor PFS. Multivariate analysis adjusted according to the clinicopathological features was carried out for MTV, TLG, SUVmax, tumor size, and CA125. Only TLG showed a significant difference (P = 0.038), and a 3.915‐fold increase in the hazard ratio of PFS. Both MTV and TLG (especially TLG) could serve as potential surrogate biomarkers for recurrence in patients who undergo primary cytoreductive surgery followed by platinum‐based chemotherapy, and could identify patients at high risk of recurrence who need more aggressive treatment.

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confidence: 99%

Metabolic tumor burden predicts prognosis of ovarian cancer patients who receive platinum‐based adjuvant chemotherapy

et al. 2016

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“…The lack of prognostic value for the semiquantitative parameters may derive from the heterogeneous histological subtypes of the malignancy, as SUV max may differ by histological subtype [6]. However, the contention may also relate to the patient sample.…”

Section: Discussionmentioning

confidence: 96%

“…1 8 F-Fluoro-2-deoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) has been investigated in patients with epithelial ovarian cancer, displaying high diagnostic accuracy, with significant correlation to histopathology [4,5]. Its application during the staging process plays a pivotal role in the prognostic assessment, as reported by many studies correlating qualitative and semiquantitative parameters to different outcomes [6][7][8][9][10]. In addition, volumetric uptake parameters such as metabolic tumour volume (MTV) and total lesion glycolysis (TLG) have been proven to be reliable prognostic factors [11,12].…”

Section: Introductionmentioning

confidence: 98%

Predictive value of 18F-FDG PET/CT in restaging patients affected by ovarian carcinoma: a multicentre study

Caobelli

Alongi

Evangelista

et al. 2015

Eur J Nucl Med Mol Imaging

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“…In recent years, FDG-PET/CT has been utilized not only for its production of morphological images, but also for its ability to provide information regarding biological functions and metabolism. The maximum standardized uptake value max (SUVmax) of FDG-PET/CT that reflects glucose metabolism of tumors has been reported to be an imaging biomarker for prognostic prediction, therapy evaluation, and chemosensitivity [5]- [8]. We previously reported that the SUVmax of pretreatment primary tumors differs depending on the histological type of epithelial ovarian cancer, that SUVmax is lower in CCC than in serous carcinoma and endometrioid carcinoma, and that SUVmax can be a biomarker to predict prognosis in CCC [5].…”

Section: Introductionmentioning

confidence: 99%

“…The maximum standardized uptake value max (SUVmax) of FDG-PET/CT that reflects glucose metabolism of tumors has been reported to be an imaging biomarker for prognostic prediction, therapy evaluation, and chemosensitivity [5]- [8]. We previously reported that the SUVmax of pretreatment primary tumors differs depending on the histological type of epithelial ovarian cancer, that SUVmax is lower in CCC than in serous carcinoma and endometrioid carcinoma, and that SUVmax can be a biomarker to predict prognosis in CCC [5]. When the SUVmax reflects the biological characteristics of the disease, even at stage I CCC, it can be a useful criterion for treatment decisions.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Fluorodeoxyglucose Positron Emission Tomography Maximum Standardized Uptake Value in Stage I Ovarian Clear Cell Carcinoma: A Retrospective Observational Study

Konishi¹,

Takehara²,

Okame³

et al. 2016

OJOG

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Background: Ovarian clear cell carcinoma (CCC) is often diagnosed at stage I. However, because of the poor prognosis of recurrent cases, even for stage Ia CCC, treatment strategies such as expansion of fertility-sparing treatment and omission of adjuvant chemotherapy have been carefully discussed in recent years. We previously reported the possibility of the maximum standardized uptake value (SUVmax) as a biomarker of CCC prognosis prediction at all stages. In this study, we confirmed differences in SUVmax within stage I CCC and considered treatment strategies. Methods: We selected all 31 patients with ovarian CCC stage I who underwent fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) before treatment between 2006 and 2013 at our institution. This retrospective study was based on their medical records. Results: Clinical tumor stage was Ia in 13 patients, and Ic in 18 (Ic (b) in 11, and Ic (1) + Ic (2) in seven). There were no differences in serum CA125 level, maximum tumor diameter or mural nodules. Median SUVmax was signifi-* Corresponding author. H. Konishi et al. 137 cantly higher in stage Ic (5.87) than stage Ia (3.08) cases (P = 0.02). Progression-free survival was longer in the low SUVmax group than the high SUVmax group (P = 0.08). Conclusions: SUVmax for primary lesions in CCC was significantly higher in stage Ic than stage Ia. As SUVmax represents a prognostic factor in stage I CCC, these findings may suggest SUVmax as an indicator for the application of fertility-sparing surgery and omission of adjuvant chemotherapy for stage Ia CCC.

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Maximum Standardized Uptake Value of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Is a Prognostic Factor in Ovarian Clear Cell Adenocarcinoma

Abstract: Maximum SUV on preoperative FDG-PET/CT in ovarian epithelial cancer differs according to histologic type. In clear cell AC, SUVmax may represent a prognostic factor.

Cited by 35 publications

References 10 publications

Metabolic tumor burden predicts prognosis of ovarian cancer patients who receive platinum‐based adjuvant chemotherapy

Metabolic tumor burden predicts prognosis of ovarian cancer patients who receive platinum‐based adjuvant chemotherapy

Predictive value of 18F-FDG PET/CT in restaging patients affected by ovarian carcinoma: a multicentre study

Prognostic Significance of Fluorodeoxyglucose Positron Emission Tomography Maximum Standardized Uptake Value in Stage I Ovarian Clear Cell Carcinoma: A Retrospective Observational Study

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