Maximum standardized uptake value from quantitative bone single-photon emission computed tomography/computed tomography in differentiating metastatic and degenerative joint disease of the spine in prostate cancer patients

Rohani, Mohd Fazrin Mohd; Nawi, Norazlina Mat; Shamim, Syed Ejaz; Sohaimi, Wan Fatihah Wan; Zainon, Wan Mohd Nazlee Wan; Musarudin, Marianie; Said, M A; Hashim, Hazlin

doi:10.1007/s12149-019-01410-4

Cited by 21 publications

(32 citation statements)

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“…Our results demonstrated that SUV max of normal vertebrae, benign bone lesion and malignant bone metastasis foci were signi cantly different from each other in thoracic and lumbar regions of male and female patients. The results were consistent with previous studies [15,16], which veri ed the differentiating diagnostic value of SUV max in bone lesions using SPECT/CT. Different from previous studies, based on our ndings in normal vertebrae, data comparison was performed on lesions in different gender and vertebral region groups.…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, in our study, the VOI contained the cortical bone with high bone salt metabolism which could lead to the increased SUV max . The SUV max of normal vertebra in our study was similar to the previously reported studies which also included bone cortex in their VOIs [11][12][13][14][15][16][17]. It is well known that bone lesions including tumors, in ammation and other diseases often ended up with cortical hyperplasia [17,18].…”

Section: Discussionsupporting

confidence: 88%

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Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae Assessed Using Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

Meng

You

et al. 2020

Preprint

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Background: Quantitative bone SPECT/CT is useful for disease follow up and inter-patient comparison. For bone metastatic malignant lesions, spine is the most commonly invaded site. However, Quantitative studies with large samples size investigating all the segments of normal cervical, thoracic and lumbar vertebrae are seldom reported. This study was to evaluate the quantitative tomography of normal vertebrae using 99mTc-MDP with SPECT/CT to investigate the feasibility of standardized uptake value (SUV) for differential diagnosis of benign and malignant bone lesions. Methods: A retrospective study was carried out involving 221 patients (116 males and 105 female) who underwent SPECT/CT scan using 99mTc-MDP. The maximum SUV (SUVmax), mean SUV (SUVmean) and CT values (Hounsfield Unit, HU) of 2416 normal vertebrae bodies, 157 benign bone lesions and 118 malignant bone metastasis foci were obtained. The correlations between SUVmax and CT values, age, height, weight of normal vertebrae were analyzed. Statistical analysis was performed with data of normal, benign and malignant groups corresponding to same sites and gender. Results: The SUVmax and SUVmean of vertebrae in males were markedly higher than those in females (P<0.0009). The SUVmax of each vertebral segment showed a strong negative correlation with CT values in both males and females (r=-0.89 and -0.92, respectively; P<0.0009). The SUVmax of vertebrae also showed significant correlation with weight and height in males (r=0.4, P<0.0009; r=0.28, P=0.005), and significant correlation with weight in females (r=0.32, P=0.009). The SUVmax of normal group, benign bone lesion group and malignant bone metastasis foci group showed statistical differences in both males and females. Conclusion: Our study evaluated SUVmax and SUVmean of normal vertebrae, benign bone lesion and malignant bone metastasis foci with a large sample population. Preliminary results proved the potential value of SUVmax in differentiation benign and malignant bone lesions. The results may provide a quantitative reference for clinical diagnosis and the evaluation of therapeutic response in vertebral lesions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae Assessed Using Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

Meng

You

et al. 2020

Preprint

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“…Therefore, SUV acquisition could potentially be a useful parameter to differentiate bone lesions and normal vertebrae. In a recently published paper by Mohd Rohani et al [ 27 ] involving 34 prostate cancer patients utilizing SPECT/CT, a cutoff SUV max value of 20 was suggested to distinguish between DJD and bone metastases of the spine. However, no cutoff SUV was proposed by the authors to discriminate DJD from normal vertebrae.…”

Section: Discussionmentioning

confidence: 99%

Standardized Uptake Value from Semiquantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography in Normal Thoracic and Lumbar Vertebrae of Breast Cancer Patients

et al. 2020

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This study aims to semiquantitatively evaluate the standardized uptake value (SUV) of 99m Tc-methylene diphosphonate (MDP) radionuclide tracer in the normal vertebrae of breast cancer patients using an integrated single-photon emission computed tomography (SPECT)/computed tomography (CT) scanner. Overview of Literature: Molecular imaging techniques using gamma cameras and stand-alone SPECT have traditionally been utilized to evaluate metastatic bone diseases. However, these methods lack quantitative analysis capabilities, impeding accurate uptake characterization. Methods: A total of 30 randomly selected female breast cancer patients were enrolled in this study. The SUVmean and SUVmax values for 286 normal vertebrae at the thoracic and lumbar levels were calculated based on the patients' body weight (BW), body surface area (BSA), and lean body mass (LBM). Additionally, 106 degenerative joint disease (DJD) lesions of the spine were also characterized, and both their BW SUVmean and SUVmax values were obtained. A receiver operating characteristic (ROC) curve analysis was then performed to determine the cutoff value of SUV for differentiating DJD from normal vertebrae. Results: The mean±standard deviations for the SUVmean and SUVmax in the normal vertebrae displayed a relatively wide variability: BW=3.92±0.27 and 6.51±0.72, BSA=1.05±0.07 and 1.75±0.17, and LBM=2.70±0.19 and 4.50±0.44, respectively. Generally, the SUVmean had a lower coefficient of variation than the SUVmax. For DJD, the mean±standard deviation for the BW SUVmean and SUVmax was 5.26±3.24 and 7.50±4.34, respectively. Based on the ROC curve, no optimal cutoff value was found to differentiate DJD from normal vertebrae. Conclusions: In this study, the SUV of 99m Tc-MDP was successfully determined using SPECT/CT. This research provides an approach that could potentially aid in the clinical quantification of radionuclide uptake in normal vertebrae for the management of breast cancer patients.

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“…There are several diagnostic applications where an increased tracer uptake is correlated with the presence or severity of the disease. Multiple authors have investigated the link between the uptake of

Tc-labeled bone-seeking agents and whether a bone lesion is benign or malignant [ 26 , 27 , 28 , 29 ]. In cardiac imaging, the uptake of a

Tc-labeled bone-seeking agent has been shown to correlate with current clinical standard quantitative measures for amyloid burden in cardiac amyloidosis, therapy response, extracellular volume as measured on NMR, and left ventricular mass index, as measured on echocardiography [ 30 ].…”

Section: Understanding the Need For Quantificationmentioning

confidence: 99%

Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise

et al. 2021

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The application of absolute quantification in SPECT/CT has seen increased interest in the context of radionuclide therapies where patient-specific dosimetry is a requirement within the European Union (EU) legislation. However, the translation of this technique to diagnostic nuclear medicine outside this setting is rather slow. Clinical research has, in some examples, already shown an association between imaging metrics and clinical diagnosis, but the applications, in general, lack proper validation because of the absence of a ground truth measurement. Meanwhile, additive manufacturing or 3D printing has seen rapid improvements, increasing its uptake in medical imaging. Three-dimensional printed phantoms have already made a significant impact on quantitative imaging, a trend that is likely to increase in the future. In this review, we summarize the data of recent literature to underpin our premise that the validation of diagnostic applications in nuclear medicine using application-specific phantoms is within reach given the current state-of-the-art in additive manufacturing or 3D printing.

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Maximum standardized uptake value from quantitative bone single-photon emission computed tomography/computed tomography in differentiating metastatic and degenerative joint disease of the spine in prostate cancer patients

Cited by 21 publications

References 18 publications

Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae Assessed Using Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae Assessed Using Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

Standardized Uptake Value from Semiquantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography in Normal Thoracic and Lumbar Vertebrae of Breast Cancer Patients

Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise

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Maximum standardized uptake value from quantitative bone single-photon emission computed tomography/computed tomography in differentiating metastatic and degenerative joint disease of the spine in prostate cancer patients

Cited by 21 publications

References 18 publications

Standardized Uptake Values&nbsp;of 99mTc-MDP in Normal Vertebrae Assessed Using&nbsp;Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

Standardized Uptake Values&nbsp;of 99mTc-MDP in Normal Vertebrae Assessed Using&nbsp;Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

Standardized Uptake Value from Semiquantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography in Normal Thoracic and Lumbar Vertebrae of Breast Cancer Patients

Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise

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Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae Assessed Using Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions

Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae Assessed Using Quantitative SPECT/CT for Differentiation Diagnosis of Benign and Malignant Bone Lesions