Abstract:We present a new approach to inferring global geometric state of chromatin from Hi-C data. Chromatin conformation capture techniques (3C, and its variants: 4C, 5C, Hi-C, etc.) probe the spatial structure of the genome by identifying physical contacts between 30 genomic loci within the nuclear space. In whole-genome conformation capture (Hi-C) experiments, the signal can be interpreted as spatial proximity between genomic loci and physical distances can be estimated from the data. However, the results of these … Show more
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