“…PTZ is known to induce seizures in humans 34, 35 and lower seizure threshold in epileptic patients 36 . PTZ-induced seizures in the zebrafish occurred spontaneously, repeatedly, and throughout the brain, consistent with earlier reports 22, 26, 37, 38 . Furthermore, the ictal LFP had spectral features 39 similar to those observed in rodent models 40 and human patients 41 : at initiation, ictal events displayed an abrupt broad-frequency power increase, followed by a longer period where power was restricted to a slightly lower frequency range, concluding with a return to baseline power at the time of termination.…”