Maximal intermittent contractions of the first dorsal interosseous inhibits voluntary activation of the contralateral homologous muscle

Kavanagh, Justin J.; Feldman, Matthew; Simmonds, Michael J.

doi:10.1152/jn.00367.2016

Cited by 12 publications

(21 citation statements)

References 32 publications

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“…The support for this statement is twofold. First, VA levels in the un-fatigued conditions were the expected values with reference to the literature reports, either considering empirical data 31 or modelling 32 . Second, when fatigue developed by repetitions of MVC over time (without ft ), we showed a strong lineal relationship between MVC reduction and central drive waning.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Finger Tapping Fatiguing Task on M1-Intracortical Inhibition and Central Drive to the Muscle

Madrid

Madinabeitia-Mancebo

Cudeiro

et al. 2018

Sci Rep

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The central drive to the muscle reduces when muscle force wanes during sustained MVC, and this is generally considered the neurophysiological footprint of central fatigue. The question is if force loss and the failure of central drive to the muscle are responsible mechanisms of fatigue induced by un-resisted repetitive movements. In various experimental blocks, we validated a 3D-printed hand-fixation system permitting the execution of finger-tapping and maximal voluntary contractions (MVC). Subsequently, we checked the suitability of the system to test the level of central drive to the muscle and developed an algorithm to test it at the MVC force plateau. Our main results show that the maximum rate of finger-tapping dropped at 30 s, while the excitability of inhibitory M1-intracortical circuits and corticospinal excitability increased (all by approximately 15%). Furthermore, values obtained immediately after finger-tapping showed that MVC force and the level of central drive to the muscle remained unchanged. Our data suggest that force and central drive to the muscle are not determinants of fatigue induced by short-lasting un-resisted repetitive finger movements, even in the presence of increased inhibition of the motor cortex. According to literature, this profile might be different in longer-lasting, more complex and/or resisted repetitive movements.

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Section: Discussionmentioning

confidence: 99%

Effects of a Finger Tapping Fatiguing Task on M1-Intracortical Inhibition and Central Drive to the Muscle

Madrid

Madinabeitia-Mancebo

Cudeiro

et al. 2018

Sci Rep

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“…; Kavanagh et al . ). These effects are enhanced by paroxetine and reduced by cyproheptadine (a 5‐HT 2 antagonist), and their relationship with the strength of voluntary contraction is consistent with an association between the level of serotonergic release onto the motoneurones and the level of motor activity (Wei et al .…”

Section: Discussionmentioning

confidence: 97%

“…In particular, the gain of tendon vibration reflexes and stretch reflexes is increased by enhancing the availability of endogenous 5-HT (Wei et al 2014). Moreover, voluntary contractions in a single limb cause changes in tremor and force control for the opposite limb, which aligns with the known 5-HT effects on spinal motoneurones (Kavanagh et al 2013;Wei et al 2014;Kavanagh et al 2016). These effects are enhanced by paroxetine and reduced by cyproheptadine (a 5-HT 2 antagonist), and their relationship with the strength of voluntary contraction is consistent with an association between the level of serotonergic release onto the motoneurones and the level of motor activity (Wei et al 2014).…”

Section: -Ht Reuptake Inhibition Requires Serotonergic Drive To Modumentioning

confidence: 88%

Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions

Kavanagh

McFarland

Taylor

2018

The Journal of Physiology

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Key points Animal preparations have revealed that moderate synaptic release of serotonin (5‐HT) onto motoneurones enhances motor activity via activation of 5‐HT2 receptors, whereas intense release of 5‐HT causes spillover of 5‐HT to extrasynaptic 5‐HT1A receptors on the axon initial segment to reduce motoneurone activity. We explored if increasing extracellular concentrations of endogenously released 5‐HT (via the selective serotonin reuptake inhibitor paroxetine) influences the ability to perform unfatigued and fatigued maximal voluntary contractions in humans. Following the ingestion of paroxetine, voluntary muscle activation and torque generation increased during brief unfatigued maximal contractions. In contrast, the ability to generate maximal torque with increased 5‐HT availability was compromised under fatigued conditions, which was consistent with paroxetine‐induced reductions in motoneurone excitability and voluntary muscle activation. This is the first in vivo human study to provide evidence that 5‐HT released onto the motoneurones could play a role in central fatigue. Abstract Brief stimulation of the raphe–spinal pathway in the turtle spinal cord releases serotonin (5‐HT) onto motoneurones to enhance excitability. However, intense release of 5‐HT via prolonged stimulation results in 5‐HT spillover to the motoneurone axon initial segment to activate inhibitory 5‐HT1A receptors, thus providing a potential spinal mechanism for exercise‐induced central fatigue. We examined how increased extracellular concentrations of 5‐HT affect the ability to perform brief, as well as sustained, maximal voluntary contractions (MVCs) in humans. Paroxetine was used to enhance 5‐HT concentrations by reuptake inhibition, and three studies were performed. Study 1 (n = 14) revealed that 5‐HT reuptake inhibition caused an ∼4% increase in elbow flexion MVC. However, when maximal contractions were sustained, time‐to‐task failure was reduced and self‐perceived fatigue was higher with enhanced availability of 5‐HT. Study 2 (n = 11) used twitch interpolation to reveal that 5‐HT‐based changes in motor performance had a neural basis. Enhanced 5‐HT availability increased voluntary activation for the unfatigued biceps brachii and decreased voluntary activation of the biceps brachii by 2–5% following repeated maximal elbow flexions. The final study (n = 8) investigated whether altered motoneurone excitability may contribute to 5‐HT changes in voluntary activation. F‐waves of the abductor digiti minimi (ADM) were unaffected by paroxetine for unfatigued muscle and marginally affected following a brief 2‐s MVC. However, F‐wave area and persistence were significantly decreased following a prolonged 60‐s MVC of the ADM. Overall, high serotonergic drive provides a spinal mechanism by which higher concentrations of 5‐HT may contribute to central fatigue.

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“…Thus, the final number of studies included was 52[118][119][120][121][122][123][124][125][126][127][128][129]: citations for studies not otherwise referenced in the manuscript but included in the data extraction table]. Details of the search and inclusion process are shown in the flow chart (figure 1).…”

mentioning

confidence: 99%

Non-local muscle fatigue effects on muscle strength, power, and endurance in healthy individuals: A systematic review and meta-analysis

Behm

Alizadeh

Anvar

et al. 2020

Preprint

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Objective: To examine whether non-local muscle fatigue occurs following performance of a fatiguing bout of exercise of a different muscle(s).Design: Systematic review and meta-analysis.Search and Inclusion: A systematic literature search using a Boolean search strategy was conducted with PubMed, SPORTDiscus, Web of Science, and Google Scholar in April 2020 and was supplemented with additional ‘snowballing’ searches up to September 2020. To be included in our analysis, studies had to include at least one intentional performance measure (i.e., strength, endurance, or power), which if reduced could be considered evidence of muscle fatigue, and also had to include the implementation of a fatiguing protocol to a location (i.e., limb or limbs) that differed to those for which performance was measured. We excluded studies that measured only mechanistic variables such as electromyographic, or spinal/supraspinal excitability. After search and screening, 52 studies were eligible for inclusion including 57 groups of participants (median sample = 11) and a total of 303 participants.Results: The main multilevel meta-analysis model including all effects sizes (278 across 50 clusters [median = 4, range = 1 to 18 effects per cluster) revealed a trivial point estimate with high precision for the interval estimate (-0.02 [95%CIs = -0.14 to 0.09]), yet with substantial heterogeneity (Q(277) = 642.3, p < 0.01), I2 = 67.4%). Subgroup and meta-regression analyses showed that NLMF effects were not moderated by study design (between vs. within-participant), homologous vs. heterologous effects, upper or lower body effects, participant training status, sex, age, the time of post-fatigue protocol measurement, or the severity of the fatigue protocol. However, there did appear to be an effect of type of outcome measure where both strength (0.11 [95%CIs = 0.01 to 0.21]) and power outcomes had trivial effects (-0.01 [95%CIs = -0.24 to 0.22]), whereas endurance outcomes showed moderate albeit imprecise effects (-0.54 [95%CIs = -0.95 to -0.14]).Conclusions: Overall, the findings do not support the existence of a general NLMF effect; however, when examining specific types of performance outcomes there may be an effect specifically upon endurance-based outcomes (i.e., time to task failure). However, there are relatively fewer studies that have examined endurance effects or mechanisms explaining this possible effect, in addition to fewer studies including women or younger and older participants, and considering causal effects of prior training history through the use of longitudinal intervention study designs. Thus, it seems pertinent that future research on NLMF effects should be redirected towards these still relatively unexplored areas.

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Maximal intermittent contractions of the first dorsal interosseous inhibits voluntary activation of the contralateral homologous muscle

Cited by 12 publications

References 32 publications

Effects of a Finger Tapping Fatiguing Task on M1-Intracortical Inhibition and Central Drive to the Muscle

Effects of a Finger Tapping Fatiguing Task on M1-Intracortical Inhibition and Central Drive to the Muscle

Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions

Non-local muscle fatigue effects on muscle strength, power, and endurance in healthy individuals: A systematic review and meta-analysis

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