Maximal glomerular diameter as a 10-year prognostic indicator for IgA nephropathy

Kataoka, Hiroshi; Ohara, Miho; Honda, Kazuho; Mochizuki, Takahiro; Nitta, Kosaku

doi:10.1093/ndt/gfr139

Cited by 40 publications

(49 citation statements)

References 34 publications

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“…8 The rate of the number of segmentally sclerosed glomeruli/remnant glomeruli (total glomerular number minus GS glomeruli) is expressed. 9 The existence of glomerular hypertrophy is defined when the diameter of capillary area is over 250μm [ 13 ]. 10 mtDNA mutation was surveyed in blood, urine, and kidney specimens by the PCR-Luminex method [ 11 ] except Mit2 patient, who was already diagnosed by a gene analysis in the other hospital.…”

Section: Resultsmentioning

confidence: 99%

Pathological similarities between low birth weight-related nephropathy and nephropathy associated with mitochondrial cytopathy

et al. 2014

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BackgroundIndividuals born with a low birth weight (LBW) have a higher risk of developing kidney dysfunction during their lifetime and sometimes exhibit focal segmental glomerulosclerosis (FSGS) lesions in their glomeruli. We herein try to obtain other pathological characteristics of LBW-related nephropathy.MethodsWe retrospectively evaluated the renal pathology of four patients demonstrating FSGS with a history of LBW. Two mitochondrial cytopathy patients were also analyzed. DNA mutations were surveyed using a PCR-Luminex assay.ResultsIn all four FSGS patients with a history of LBW, focal segmental glomerulosclerosis were detected. Interestingly, granular swollen epithelial cells (GSECs), which have previously been reported exclusively in patients with mitochondrial cytopathy, were also observed in the distal tubules and/or collecting ducts of all four patients with a history of low birth weight in this study. Electron microscopy revealed that these granular swollen epithelial cells included an increased number of enlarged mitochondria. Furthermore, cytochrome c oxidase subunit IV staining of patients with a history of low birth weight and patients with mitochondrial DNA mutations showed unbalanced expression patterns in glomeruli and a part of tubular cells. However, no mitochondrial gene mutations were detected in any of our four patients with low birth weight-related nephropathy.ConclusionsThis is the first report to show the pathological similarities not only in glomeruli but also tubuli between nephropathy with a LBW history and nephropathy with mitochondrial cytopathy.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_181

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Section: Resultsmentioning

confidence: 99%

Pathological similarities between low birth weight-related nephropathy and nephropathy associated with mitochondrial cytopathy

et al. 2014

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“…The glomerular size was measured as glomerular diameter (GD) using imagej 1.51t software (National Institutes of Health, Bethesda, MD, USA; http://rsb.info.nih.gov/ij). Maximum GD was calculated as the mean of the following two measurements: maximal diameter of the glomerulus and the maximal chord perpendicular to the maximal diameter [19].…”

Section: Methodsmentioning

confidence: 99%

Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice

et al. 2020

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Diabetic kidney disease (DKD) is among the most common and serious complications of both type 1 and type 2 diabetes. In this study, we used KK/Ta‐Ins2Akita (KK‐Akita) mice as a model of DKD and KK/Ta (KK) mice as controls to identify novel factors related to the development/progression of DKD. Capillary electrophoresis coupled with mass spectrometry analysis revealed that circulating Asp (l‐aspartic acid) levels in diabetic KK‐Akita mice tend to be lower than those in control KK mice. Therefore, we evaluated the effect of Asp supplementation to prevent the progression of DKD in KK‐Akita mice. Mice were divided into three groups: (a) untreated KK mice (Control group), (b) untreated KK‐Akita mice (DKD group), and (c) treated (double‐volume Asp diet) KK‐Akita mice (Tx group). Kidney sections were stained with fluorescein isothiocyanate‐labeled lectins, wheat germ agglutinin (WGA), and anti‐endothelial nitric oxide synthase (eNOS) antibody for evaluation of endothelial surface layer (ESL) and NO synthesis. The mesangial area and glomerular size in the DKD group were significantly larger than those in the Control group; however, there was no significant difference in those between the DKD and Tx groups. Albuminuria, the ratio of foot process effacement, and thickness of glomerular basement membrane in the Tx group were significantly lower than those in the DKD group. Furthermore, the expression levels of glomerular WGA and microvascular eNOS in the Tx group improved significantly and approached the level in the Control group. In conclusion, the improvement of albuminuria in the Tx group may be caused by the reduction of oxidative stress in the kidneys, which may lead to the subsequent improvement of glomerular ESL.

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“…Ten mature glomeruli per section were selected at random for analysis of glomerular diameter. We assessed the maximum diameter ( d ) of each glomerulus, as an indicator of glomerular size (Kataoka et al, ) by Aperio image analysis software. Glomerulus in six sections were assessed and the diameter averaged in each animal in both the groups; the mean glomerular diameter was then compared between the neonatal hyperoxia‐exposed and the room air groups. Glomerular number & density : Each kidney was evaluated as follows: every 13th section of the kidney was selected and examined histologically and all the glomeruli in that section were counted.…”

Section: Methodsmentioning

confidence: 99%

Long‐Term Effects of Neonatal Hyperoxia in Adult Mice

Kumar

Wang

Kishkurno

et al. 2018

The Anatomical Record

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The outcomes of premature infants have improved greatly; however, the health risks in adulthood are still relatively unclear. Bronchopulmonary dysplasia (BPD) in premature infants is a major risk factor for alteration in lung function and predisposition to respiratory morbidity, and is associated with hyperoxia. The study explores the effect of neonatal hyperoxia on organ systems in adult mice. Newborn mouse litters were randomized to 85%O or room air (RA) on P3 for 12 days; mice were sacrificed at P3, P7, P15, 3 months and 9 months. Lungs were assessed by histopathology, radial alveolar count, mean linear intercept, and α-Smooth muscle actin immunohistochemistry. Aortic assessment included histology, wall thickness, elastin, and collagen content. Glomerular histology and nephron number were assessed in the kidneys. Hyperoxia-exposed mice had progressive alveolar simplification and poor weight gain over time. Greater thickness of pulmonary arterioles by 3 months and a higher Fulton index by 9 months suggest worsening pulmonary hypertension. Aortic wall thickness to lumen ratio was greater with a lower aortic elastin-to-collagen ratio suggesting long-term effects of neonatal hyperoxia. Hyperoxia-exposed mice at 9 months had smaller glomeruli as indicated by glomerular diameter and volume. Prolonged neonatal hyperoxia during the critical period of development induces irreversible lung damage, pulmonary hypertension and structural changes in the kidneys and aorta in adult mice. This could have implications for chronic adult diseases following exposure to high levels of oxygen in the newborn period. Anat Rec, 301:717-726, 2018. © 2017 Wiley Periodicals, Inc.

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Maximal glomerular diameter as a 10-year prognostic indicator for IgA nephropathy

Abstract: The results of this study suggest that Max GD is a simple quantitative prognostic indicator of the disease progression in IgAN patients.

Cited by 40 publications

References 34 publications

Pathological similarities between low birth weight-related nephropathy and nephropathy associated with mitochondrial cytopathy

Pathological similarities between low birth weight-related nephropathy and nephropathy associated with mitochondrial cytopathy

Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice

Long‐Term Effects of Neonatal Hyperoxia in Adult Mice

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