Maximal detrusor pressure can be predicted using technetium-99m-mercaptoacetyltriglycin renal scintigraphy in the early stages of spinal cord injury

Abstract

Study design: Retrospective cohort study Objective: To investigate the potential of technetium-99m-mercaptoacetyltriglycine (99mTc-MAG-3) renal scintigraphy in predicting maximal detrusor pressure in the early stages of spinal cord injury (SCI). Setting: Tertiary rehabilitation facility Methods: Medical records of individuals with SCI admitted between January 202 and April 2023 who underwent both 99mTc-MAG-3 renal scintigraphy and urodynamic study within 90 days of SCI onset were retrospectively reviewed. Pearson's coefficient analysis was performed to determine the relationship between 99mTc-MAG-3 renal scintigraphy findings and urodynamic study findings. Multivariate linear regression analysis was performed to determine the best predictors of maximal detrusor pressure. Multivariate logistic regression analysis was performed to determine risk factors for high detrusor pressure. Results: Ninety-four participants were enrolled in this study. The Pearson's correlation analysis showed that ERPF and ERPF (% predicted) were significantly correlated with maximal detrusor pressure. The multivariate linear regression analysis demonstrated that ERPF (% predicted) was a significant predictor of maximal detrusor pressure. The multivariate logistic regression analysis showed that ERPF (% predicted) was significantly associated with high detrusor pressure. Receiver operating characteristic curves demonstrated that the predictive model had an area under the curve of 0.725, and the cut-off value for ERPF (% predicted) was 64.05%, with a sensitivity of 1.000 and specificity of 0.429. Conclusion: These results suggest that 99mTc-MAG-3 renal scintigraphy may be useful for predicting high detrusor pressure in early SCI, and may guide the timing of urodynamic studies in individuals with early SCI for appropriate management of neurogenic bladder.