Maxillofacial Tumors and Tumor-like Lesions in a Nigerian Teaching Hospital: an eleven year retrospective analysis

Bassey, GO; Osunde, OD; Anyanechi, CE

doi:10.4314/ahs.v14i1.9

Cited by 43 publications

(37 citation statements)

References 32 publications

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“…Ameloblastoma is an aggressive odontogenic tumor that forms from odontogenic epithelium within a mature fibrous stroma devoid of odontogenic ectomesenchyme (Sciubba et al , ). Although classified as a benign tumor, ameloblastoma is also the most common odontogenic tumor of epithelial origin with severe clinical implications (Bassey et al , ). Ameloblastoma has a locally aggressive growth pattern; about 70% of cases undergo malignant transformation, and up to 2% metastasize to other sites (Odukoya and Effiom, ; DeVilliers et al , ).…”

Section: Introductionmentioning

confidence: 99%

“…Ameloblastoma constitutes about 14% of all jaw tumors and cysts, and it is the most prevalent odontogenic tumors in developing countries (Lasisi et al , ; Oginni et al , ). The global incidence of ameloblastoma is 0.5 cases per million persons per year (Brown and Betz, ), and it is a highly encountered odontogenic tumor in Africa and China (Bassey et al , ). In the Western Hemisphere, ameloblastoma is second to odontoma as the most common odontogenic tumor, but the African American population is five times more likely to develop ameloblastoma compared to the Caucasian population (McClary et al , ).…”

Section: Introductionmentioning

confidence: 99%

“…Despite the similarities, it is intriguing that ameloblastoma still displays a distinctive clinically invasive and aggressive growth pattern. Due to naivety and limited healthcare facilities, ameloblastoma patients in developing countries often present with massively grown lesions before seeking care (Anyanechi and Saheeb, ; Bassey et al , ; Figure ).…”

Section: Introductionmentioning

confidence: 99%

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Ameloblastoma: current etiopathological concepts and management

et al. 2017

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Ameloblastoma is a benign odontogenic tumor of epithelial origin. It is locally aggressive with unlimited growth capacity and has a high potential for malignant transformation as well as metastasis. Ameloblastoma has no established preventive measures although majority of patients are between ages 30 and 60 years. Molecular and genetic factors that promote oncogenic transformation of odontogenic epithelium to ameloblastoma are strongly linked to dysregulation of multiple genes associated with mitogen-activated protein kinase, sonic hedgehog, and WNT/b-catenin signaling pathways. Treatment of ameloblastoma is focused on surgical resection with a wide margin of normal tissue because of its high propensity for locoregional invasion; but this is often associated with significant patient morbidity. The relatively high recurrence rate of ameloblastoma is influenced by the type of molecular etiological factors, the management approach, and how early the patient presents for treatment. It is expected that further elucidation of molecular factors that orchestrate pathogenesis and recurrence of ameloblastoma will lead to new diagnostic markers and targeted drug therapies for ameloblastoma. Oral Diseases (2018) 24, 307-316

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ameloblastoma: current etiopathological concepts and management

et al. 2017

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“…Ameloblastoma is the most frequent benign but locally aggressive odontogenic tumor of epithelial origin, representing about 14% of the jaw tumors and cysts [1][2][3]. In Africa, it afflicts predominantly patients between the third and the fourth decades of life [4,5].…”

Section: Introductionmentioning

confidence: 99%

Maxillary ameloblastoma: results of the treatment in 11 patients

Béogo

Konsem

Millogo

et al. 2018

J Oral Med Oral Surg

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Introduction: Surgery of maxilla ameloblastoma is mutilating and the tumor propensity for recurrence high. Patients and Methods: The oral and visual functions, facial morphology and tumor recurrence in 11 patients after maxillary ameloblastoma surgery are retrospectively reviewed. Results: Facial morphology was satisfactory in 7 patients who had all tumor removal by a type 1 or 2A maxillectomy and surgical wound closure. Out of these patients, 4 who had dental rehabilitation by conventional prosthesis presented satisfactory mastication. Four patients subjected to the tumor removal by a type 3 maxillectomy had all facial asymmetry. Out of these, 1 patient who did not have the orbital floor defect repair presented diplopia and enophtalmos, and 2 patients subjected to the palate defect repair by a prosthetic obturator or oral mucosa had elocution impairment. The tumor recurrence occurred in 2 patients after tumor enucleation and in 1 patient after radical surgery out of 8 patients who had a postoperative follow-up. Discussion: In ameloblastoma surgery, achieving both the tumor recurrence prevention and a satisfactory facial reconstruction is challenging. Conclusion: Avoiding the tumor recurrence should be the major goal when patient post-surgical follow-up cannot be guaranteed.

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“…Studies from Malawi [2], Zimbabwe[3], and Togo [4] report rates of anaesthetic mortality ranging from one death per 133 to 504 cases, whereas in high income countries anaesthetic mortality is 34 per million anaesthetics administered [5]. Much of the discrepancy is attributable to lack of monitoring equipment, essential medications, and inadequate anaesthetic training or supervision in LMICs [6]. Another factor is the health of the patient.…”

Section: Introductionmentioning

confidence: 99%

Retrospective Review of the Anaesthetic Management of Maxillectomies and Mandibulectomies for Benign Tumours in Sub-Saharan Africa

White¹,

Horner²,

Lai

2016

PLoS ONE

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BackgroundSafe anaesthesia is a crucial component of safe surgical care, yet anaesthetic complications are common in resource-limited settings. We describe differences in anaesthetic needs for Mandibulectomy vs. Maxillectomy in three sub-Saharan African countries.Materials and MethodsRetrospective review of patients undergoing minor Mandibulectomy, major Mandibulectomy, or Maxillectomy in Togo, Guinea and Republic of the Congo. Surgeries were performed on the Africa Mercy, an international non-governmental hospital ship. Primary outcomes were need for advanced airway management and intra-operative blood loss. Secondary outcomes were time under general anaesthesia and hospital length of stay. Multivariate regression determined the association between operation type and each outcome measure.Results105 patients were included (25 minor Mandibulectomy, 58 major Mandibulectomy, 22 Maxillectomy procedures). In-hospital mortality was 0%. 44/105 (41.9%) required an advanced airway management technique to achieve intubation, although in all cases this was anticipated prior to the procedure; no differences were noted between surgical procedure (p = 0.72). Operative procedure was a significant risk factor for intra-operative blood loss. Patients undergoing Maxillectomy lost on average 851.5 (413.3, 1289.8, p = 0.0003) mL more blood than patients undergoing minor Mandibulectomy, and 507.3 (150.3, 864.3, p = 0.007) mL more blood than patients undergoing major Mandibulectomy. Patients undergoing Maxillectomy had a significantly higher time under general anaesthesia than those undergoing minor Mandibulectomy. There was no significant difference in hospital length of stay between operation type.ConclusionAnaesthetic considerations for minor Mandibulectomy, major Mandibulectomy, and Maxillectomy differ with respect to intra-operative blood loss and time under general anaesthesia, but not need for advanced airway management or length of stay. Although advanced airway management was required in 41.9% of patients, there were no unanticipated difficult airways. With appropriate training and resources, safe anaesthesia can be delivered to patients from low-income countries requiring major head and neck surgery.

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Maxillofacial Tumors and Tumor-like Lesions in a Nigerian Teaching Hospital: an eleven year retrospective analysis

Cited by 43 publications

References 32 publications

Ameloblastoma: current etiopathological concepts and management

Ameloblastoma: current etiopathological concepts and management

Maxillary ameloblastoma: results of the treatment in 11 patients

Retrospective Review of the Anaesthetic Management of Maxillectomies and Mandibulectomies for Benign Tumours in Sub-Saharan Africa

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