Unilateral maxillary swelling is a rare condition, however we being in tertiary care centre did see a large number of these cases. All patients presenting with unilateral maxillary seen during the last 3 years were included in this retrospective study and evaluated concerning histories, diagnostic and therapeutic approaches and achieved outcomes. A total of 31 patients were seen during this period. 27 of these were benign lesions and were subdivided as follows: odontogenic cystic lesions (11/ 27), fibro-osseous lesions (8/27), secondary to extensive allergic fungal sinusitis (5/27) and mucocele (2/27). The remaining five were malignant lesions, two each were squamous cell cancer and adenocarcinoma of the maxillary sinus, and one was rhabdomyosacroma. All patients received treatment with due merit of the underlying etiology. Understanding and recognizing key diagnostic features helps in appropriate management and reducing morbidity.