Maxillary sinus floor elevation surgery with BioOss® mixed with a bone marrow concentrate or autogenous bone: test of principle on implant survival and clinical performance

Rickert, Daniela; Vissink, Arjan; Slot, Wim; Sauerbier, Sebastian; Meijer, Henny J. A.; Raghoebar, Gerry M.

doi:10.1016/j.ijom.2013.09.006

Cited by 48 publications

(60 citation statements)

References 19 publications

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“…Similar results were observed in the split mouth study of Rickert et al, 8 in which sinus augmentation with the BMAC method was compared with the conventional method, which involves biomaterial being mixed with autologous bone. In that study, 91% of the dental implants osseointegrated in the BMAC site, whereas 100% osseointegrated in the control.…”

Section: Discussionsupporting

confidence: 82%

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Duttenhoefer

Hieber

Stricker

et al. 2014

BioResearch Open Access

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Objective: Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation.Methods: Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, n=6 sinus) or BMAC (test group, n=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R.Results: Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849–1). The difference between the groups was not significant (p=0.381).Conclusion: The BMAC system is an effective and suitable “chair-side” method for clinical application in hard tissue regeneration.

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Section: Discussionsupporting

confidence: 82%

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Duttenhoefer

Hieber

Stricker

et al. 2014

BioResearch Open Access

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“…These therapies, although recent, have been extensively studied over the last two decades. Several in vivo study models have been developed and conducted using many cell lines 1,2,36,38,40 . Synthetic and natural scaffolds have been developed and applied successfully 16,24,26 .…”

Section: Discussionmentioning

confidence: 99%

“…However, recent studies using autologous DPSC, ASC and BMSC have been implemented for the repair of bone tissue in humans, producing encouraging results 8,36,38,40,44 . Follow-up periods of 3 and 6 years demonstrate that this technique can be considered safe for use in humans 8,37 .…”

Section: Discussionmentioning

confidence: 99%

“…Regeneration of bone tissue may be an interesting strategy in cases of maxillary corrections after trauma, implant-supported rehabilitation, in regions with atrophic bone tissue, and in the filling of bone defects or in intraosseous pathologies [36][37][38] . Although the incorporation of active compounds into titanium surfaces, for example, may increase biological tissue activity 39 , the direct application of stem cells, mainly from adipose tissue and bone marrow, has produced excellent results [36][37] .…”

Section: Therapies For the Regeneration Of Bone Tissuementioning

confidence: 99%

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What is the clinical applicability of regenerative therapies in dentistry?

Demarco

Kirschnick

Watson

et al. 2017

RGO, Rev. Gaúch. Odontol.

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Regenerative therapies have been widely developed in dentistry and it is important to incorporate dentists' knowledge of these new therapies RESUMOTerapias regenerativas vem sendo amplamente desenvolvidas na odontologia e o conhecimento destas novas terapias por parte dos dentistas é importante para que elas sejam incorporadas na rotina clínica odontológica. Assim, este estudo revisou a literatura acerca das terapias regenerativas e suas aplicações clínicas. A engenharia tecidual tem contribuído na mudança do paradigma restaurador das ciências da saúde. Seus pilares embasam as técnicas de regeneração de tecidos e órgãos. Apesar da grande maioria dos estudos neste campo ser in vitro, uma gama de metodologias pré-clínicas foi consolidada e estudos utilizando estes princípios já estão sendo empregados em humanos. A utilização de plasma rico em plaquetas e plasma rico em fibrina como scaffolds naturais em cirurgias para reestabelecimento de tecido ósseo e periodontal são frequentemente relatadas na literatura e ensaios clínicos utilizando esta abordagem demonstram resultados promissores. Células-tronco da polpa dental autólogas já foram aplicadas com sucesso na regeneração de tecido ósseo utilizando scaffold naturais de colágeno em humanos. Além disto, a revascularização do canal radicular já aparece na literatura como uma alternativa promissora frente a opção de apecificação do canal radicular. Esta terapia utiliza como princípio o coágulo sanguíneo como scaffold e a migração das células-tronco da papila apical para regenerar o órgão pulpar. Considerações finais: Apesar de incipientes, as terapias regenerativas já podem ser utilizadas na prática clínica odontológica. O conhecimento dos princípios que regem estas terapias deve ser compreendido pelo dentista para que sejam utilizadas na prática clínica.Termos de indexação: Fibrina. Plasma rico em plaquetas. Células-tronco. Engenharia tecidual.

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“…21,22 Numerous studies confirmed the adaptability of the use of BMC in a "one-step" procedures performed during clinical settings. [23][24][25] For instance, Sauerbier et al compared an open-system such as Ficoll-grade isolation, considered the standard technique for isolating MSC, with a closed-system such as BM aspirate concentrate method (BMAC, Harvest) for the treatment of sinus graft. They found a greater percentage of new bone formation in BMA with respect to the Ficoll system, although the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel‐coated OSPROLIFE^® HA/TTCP granules and bone marrow concentrate

et al. 2015

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The purpose of this study was to examine the in vitro cytocompatibility of a novel injectable multiphasic bone substitute (MBS) based on polysaccharide gel-coated OSPROLIFE(®) hydroxyapatite (HA)/tetracalcium phosphate (TTCP) granules combined with bone marrow concentrate (BMC). Polysaccharide gel-coated granules loaded in syringe were combined with BMC diluted in ionic crosslinking solution. The product was then maintained in culture to investigate the cytocompatibility, distribution, and osteogenic differentiation function of cells contained in the BMC. The in vitro cytocompatibility was assessed after 0, 24, and 96 h from the injectable MBS preparation using the LIVE/DEAD(®) staining kit. The results highlighted that cells remained viable after combination with the polysaccharide gel-coated granules; also, viability was maintained over time. The distribution of the cells in the product, observed using confocal microscopy, showed viable cells immersed in the polysaccharide gel formed between the granules after ionic crosslinking. The mesenchymal stromal cells (MSC) contained in the injectable MBS, the basic elements for bone tissue regeneration, were able to differentiate toward osteoblasts, producing an osteogenic matrix as evidenced by alizarin red-s (AR-S) staining. In conclusion, we found that the injectable MBS may have the potential to be used as a bone substitute by applying a "one-step" procedure in bone tissue engineering applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 894-902, 2016.

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Maxillary sinus floor elevation surgery with BioOss® mixed with a bone marrow concentrate or autogenous bone: test of principle on implant survival and clinical performance

Cited by 48 publications

References 19 publications

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

What is the clinical applicability of regenerative therapies in dentistry?

Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel‐coated OSPROLIFE^® HA/TTCP granules and bone marrow concentrate

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Maxillary sinus floor elevation surgery with BioOss® mixed with a bone marrow concentrate or autogenous bone: test of principle on implant survival and clinical performance

Cited by 48 publications

References 19 publications

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Follow-Up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

What is the clinical applicability of regenerative therapies in dentistry?

Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel‐coated OSPROLIFE® HA/TTCP granules and bone marrow concentrate

Contact Info

Product

Resources

About

Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel‐coated OSPROLIFE^® HA/TTCP granules and bone marrow concentrate