Maxillary Sinus Floor Augmentation to Enable One-Stage Implant Placement by Using Bovine Bone Substitute and Platelet-Rich Fibrin

Barbu, Horia Mihail; Andreescu, Claudia Florina; Comăneanu, Raluca Monica; Referendaru, Daniel; Mijiritsky, Eitan

doi:10.1155/2018/6562958

Cited by 20 publications

(33 citation statements)

References 33 publications

(33 reference statements)

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“…After duplicates were removed, 62 articles were screened for eligibility based on their title and abstract, from which 21 were selected for full-text review. Eleven studies were excluded, as they did not meet the inclusion criteria, nine studies were excluded because they lacked a comparison group [53][54][55][56][57][58][59][60][61], one was excluded because it was compared with patients treated for another reason [62], and another was excluded because the intervention was not of interest for this study [63]. Additionally, two articles were identified through other sources and were incorporated in the review.…”

Section: Study Selectionmentioning

confidence: 99%

Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review

et al. 2020

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Background: Sinus augmentation can be performed with or without grafting biomaterials, and to date, there is no quality evidence regarding the augmentation of the sinus floor using only platelet concentrates, which can improve the healing period and enhance bone regeneration by stimulating angiogenesis and bone formation. The main objective of this paper was to assess the effect of the sole use of platelet concentrates in sinus augmentation in terms of newly formed bone, augmented bone height, and clinical outcomes and to assess the additional beneficial effects of platelet-rich fibrin (PRF) in combination with other grafting biomaterials. Methods: A systematic review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Pooled analyses were performed with the Review Manager software. Results: For sinus elevation only using platelet concentrates, 11 studies met the inclusion criteria and were included for qualitative synthesis. Only one study was a clinical trial, which reported improved outcomes for the allograft group compared to the titanium-PRF (T-PRF) group. A total of 12 studies where PRF was used in addition to grafting biomaterials met eligibility criteria and were included in the review. Results from meta-analyses provided no additional beneficial effects of PRF in sinus augmentation in terms of bone height and percentage of soft tissue area. There was a statistically significant lower percentage of residual bone substitute material in the PRF (+) group compared to the PRF (−) group. The percentage of newly formed bone was slightly higher in the PRF (+) group, but this was not statistically significant. Conclusion: There is no robust evidence to make firm conclusions regarding the beneficial effects of the sole use of platelet concentrates in sinus augmentation. However, studies have shown favorable outcomes regarding implant survival, bone gain, and bone height. The use of PRF with other grafting biomaterials appears to provide no additional beneficial effects in sinus lift procedures, but they may improve the healing period and bone formation. Well-conducted randomized clinical trials (RCTs) are necessary to confirm the available results to provide recommendations for the clinical practice.

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Section: Study Selectionmentioning

confidence: 99%

Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review

et al. 2020

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“…All patients showed bone regeneration on histomorphometric or imaging examination. The disease types included periapical inflammatory lesion with bony defect [58, 59], IBD [60, 61] maxillary sinus augmentation [62–64], and extraction of the molar teeth [65]. Moreover, Pichotano et al [63] filled the right sinus with PRF, deproteinized bovine bone mineral (DBBM), and CM, but they filled the left side with DBBM and CM in a patient for maxillary sinus augmentation, and they found higher proportion of bone formation when using PRF on histomorphometric analysis (2,118,102 mm 3 and 975,535 mm 3 , respectively).…”

Section: Effect Of Prf On Human Oral and Maxillofacial Bone Regenementioning

confidence: 99%

“…Moreover, PRF is inadequate for space maintenance during bone regeneration; therefore, adding mineralized and rigid materials can enhance the osteoconductive and space-maintaining effect of PRF [67, 68]. In five case reports, DBBM and PRF composites were used for IBD [60], maxillary sinus augmentation [62–64], and tooth implantation [65], and new bone formation was noted in all cases. A clinical controlled study on treatment of IBD proved that adding DPBM improved the osteogenesis ability of PRF [67], and defect fill was 4.06 ± 0.87 mm at the buccal site and 3.94 ± 0.73 mm at the lingual site in the PRF-BPBM group, while defect fill was 2.21 ± 0.68 mm at the buccal and 2.06 ± 0.64 mm at the lingual site in the PRF group.…”

Section: Effect Of Prf On Human Oral and Maxillofacial Bone Regenementioning

confidence: 99%

Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

Liu

Sun

et al. 2019

BioMed Research International

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Platelet-rich fibrin (PRF) is an autologous platelet concentrate that consists of cytokines, platelets, leukocytes, and circulating stem cells. It has been considered to be effective in bone regeneration and is mainly used for oral and maxillofacial bone. Although currently the use of PRF is thought to support alveolar ridge preservation, there is a lack of evidence regarding the application of PRF in osteogenesis. In this paper, we will provide examples of PRF application, and we will also summarize different measures to improve the properties of PRF for achieving better osteogenesis. The effect of PRF as a bone graft material on osteogenesis based on laboratory investigations, animal tests, and clinical evaluations is first reviewed here. In vitro, PRF was able to stimulate cell proliferation, differentiation, migration, mineralization, and osteogenesis-related gene expression. Preclinical and clinical trials suggested that PRF alone may have a limited effect. To enlighten researchers, modified PRF graft materials are further reviewed, including PRF combined with other bone graft materials, PRF combined with drugs, and a new-type PRF. Finally, we will summarize the common shortcomings in the application of PRF that probably lead to application failure. Future scientists should avoid or solve these problems to achieve better regeneration.

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“…Its use must be contextual to its preparation because its conservation is impossible. There are many clinical studies in the literature from case reports to research on population samples and also systematic reviews in which PRF was used alone or in combination with other medications in oral surgery (for maxillary sinus lift [10][11][12][13][14], treatment of maxillary sinus perforation [15], ridge preservation [16][17][18][19][20][21]), implant dentistry (to increase implant stability and favour osseointegration [18,22], for immediate implant placing [23,24]), periodontology (periodontal and soft tissue repair [16,25,26]) and peri-implantitis treatment (peri-implant keratinized mucosa width increase [27] and retrograde peri-implantitis treatment [28]).…”

Section: Introductionmentioning

confidence: 99%

Blood Wettability of Different Dental Implant Surfaces after Different Pre-Treatments: Ultrasonic Instrumentation, Platelet-Rich Fibrin Coating, and Acid Etching. An In Vitro Study

et al. 2021

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Background: The blood wettability of titanium implant surfaces favors primary osseointegration and tissue healing in peri-implantitis. The current study aims to evaluate this property on the main different kinds of surfaces, brand new and after treatments. Methods: grade IV titanium disks were used, five machined, five laser-treated, five sandblasted. The experiment was on four steps. Between each step, specimens were sterilized. At the end of each step, a 4 µL blood drop was put on the samples, and contact angles were calculated. The steps consisted of—1: no treatment; 2: surface instrumentation with an ultrasonic titanium tip; 3: platelet-rich fibrin (PRF) coating and drying with sterile gauze; 4: etching with phosphoric acid, rinse and saline solution and air-drying. At the end of each phase, a blood drop was placed on the surfaces. Blood for PRF preparation and for calculation of contact angles was collected from a single source. Results: average wettability decreased after instrumentation, and increased after the PRF application to a superior level both to the first and second steps. The highest wettability was obtained after etching. This trend is statistically significant for machined and sandblasted surfaces. Conclusions: In the clinical environment, PRF and phosphoric acid used for conditioning exposed implant surfaces can be used for the healing of peri-implant tissues.

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Maxillary Sinus Floor Augmentation to Enable One-Stage Implant Placement by Using Bovine Bone Substitute and Platelet-Rich Fibrin

Cited by 20 publications

References 33 publications

Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review

Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review

Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

Blood Wettability of Different Dental Implant Surfaces after Different Pre-Treatments: Ultrasonic Instrumentation, Platelet-Rich Fibrin Coating, and Acid Etching. An In Vitro Study

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