2018
DOI: 10.1101/506568
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MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling

Abstract: 1 Double-stranded RNA (dsRNA) is a potent proinflammatory signature of viral infection. 2Oligomerization of RIG-I-like receptors on cytosolic dsRNA nucleates self-assembly of the 3 mitochondrial antiviral signaling protein (MAVS). In the current signaling model, the caspase 4 recruitment domains of MAVS form helical fibrils that self-propagate like prions to promote 5 signaling complex assembly. However, there is no conclusive evidence that MAVS forms 6 fibrils in cells or with the transmembrane anchor present… Show more

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Cited by 4 publications
(4 citation statements)
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“…The modeled step is but one in a pathway, using parameters that were nominal approximations of fast and slow processes. Even within this step, the true length of polymerized MAVS filaments in cells is actively debated (Hwang et al, 2019). Frankly, cell signaling is not really geared for complete kinetics like fast-acting RNA viruses are.…”
Section: Different Vros For Different Kinetic Regimes Of Viral Infectionmentioning
confidence: 99%
“…The modeled step is but one in a pathway, using parameters that were nominal approximations of fast and slow processes. Even within this step, the true length of polymerized MAVS filaments in cells is actively debated (Hwang et al, 2019). Frankly, cell signaling is not really geared for complete kinetics like fast-acting RNA viruses are.…”
Section: Different Vros For Different Kinetic Regimes Of Viral Infectionmentioning
confidence: 99%
“…With this mechanism, a small number of activated RLRs can induce oligomerization of many MAVS molecules, allowing rapid amplification of the signal. Although MAVS CARD can form filaments of infinite length in vitro, super-resolution microscopy studies suggest that the size of MAVS aggregates is limited to ~150 MAVS molecules per fibril [47]. Nevertheless, MAVS filament of this size is sufficient for activating downstream signaling pathway [47] by serving as a signaling platform to recruit and activate TRAF2/3/5/6, TBK1, and other signaling molecules [48,49].…”
Section: Cards In Innate Immune Pattern Recognition-rig-i-like Receptorsmentioning
confidence: 99%
“…In the case of infection, viroporins and other microbial proteins have been proposed to perforate mitochondrial membranes ( 43 , 57 ). Host inflammasome effector Gasdermin D can also permeabilize mitochondria ( 58 ), and the RLR adaptor MAVS has been described as a mitochondrial membrane remodeler ( 43 , 59 , 60 ), although the release of mtNA remains to be observed in this situation.…”
Section: Mitochondrial Nucleic Acid Is Interferonogenic In the Cytosolmentioning
confidence: 99%