Maturity onset diabetes of the young: Diagnosis and treatment options

Abstract

Diabetes is a complicated disease, so multiple factors are involved in its development. Nevertheless some of the patients with type 1 and 2 diabetes mellitus have a monogenic form of this disease which has different treatment options and usually fewer complications. It is estimated that about 5% of patients with type 2 diabetes melitus (T2DM) and about 10% of type 1 diabetes melitus (T1DM) are misdiagnosed and have maturity onset diabetes of the young (MODY). We present a review study of the management of most frequent monogenic forms of diabetes such as MODY 1, 2 and 3 and the possibilities of their diagnosis including in resource limited situations.

Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı

“…Şekil 1. Dünyada ve Ülkemizde MODY Dağılımı[8,20,23,38,[43][44][45][46][47][48][49][50][51][52][53][54] …”

Cytokine Profile in Patients With Maturity-onset Diabetes of the Young (MODY)

“…Most of the patients in this study satisfied the clinical criteria of MODY and were referred to our clinic, which is a tertiary center. As it is known, some MODY cases may have been misdiagnosed as T2DM, especially when diabetes started in adulthood (21). The biguanide MET is the most commonly used antidiabetic drug in T2DM, and it is almost universally preferred as first-line therapy (22,23).…”