Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled parallel group study

Morimoto-Kobayashi, Yumie; Ohara, Kazuaki; Ashigai, Hiroshi; Kanaya, Tomoka; Koizumi, Kumiko; Manabe, Fumitoshi; Kaneko, Yuji; Taniguchi, Yoshimasa; Katayama, Mikio; Kowatari, Yasuyuki; Kondo, Sumio

doi:10.1186/s12937-016-0144-2

Cited by 31 publications

(37 citation statements)

References 44 publications

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“…The study characteristics for the twenty-two studies are provided (Table 3). Nine studies (30)(31)(32)(33)(34)(35)(36)(37)(38) were excluded and justification for exclusion is provided in online Supplementary Table S1.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Effect of alcohol consumption on food energy intake: a systematic review and meta-analysis

et al. 2019

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The relationship between alcohol consumption and body weight is complex and inconclusive being potentially mediated by alcohol type, habitual consumption levels and sex differences. Heavy and regular alcohol consumption has been positively correlated with increasing body weight, although it is unclear whether this is due to alcohol consumption per se or to additional energy intake from food. This review explores the effects of alcohol consumption on food energy intake in healthy adults. CINAHL Plus, EMBASE, Medline and PsycINFO were searched through February 2018 for crossover and randomised controlled trials where an alcohol dose was compared with a non-alcohol condition. Study quality was assessed using the Effective Public Health Practice Project tool. A total of twenty-two studies involving 701 participants were included from the 18 427 papers retrieved. Studies consistently demonstrated no compensation for alcoholic beverage energy intake, with dietary energy intake not decreasing due to alcoholic beverage ingestion. Meta-analyses using the random-effects model were conducted on twelve studies and demonstrated that alcoholic beverage consumption significantly increased food energy intake and total energy intake compared with a non-alcoholic comparator by weighted mean differences of 343 (95 % CI 161, 525) and 1072 (95 % CI 820, 1323) kJ, respectively. Generalisability is limited to younger adults (18–37 years), and meta-analyses for some outcomes had substantial statistical heterogeneity or evidence of small-study effects. This review suggests that adults do not compensate appropriately for alcohol energy by eating less, and a relatively modest alcohol dose may lead to an increase in food consumption.

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Effect of alcohol consumption on food energy intake: a systematic review and meta-analysis

et al. 2019

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“…A significant decrease in LDL was seen by green tea (with effective dose of 6,000 mg/day; Tsai et al, ), N. sativa (with effective dose of 3,000 mg/day; Latiff et al, ), H. sabdariffa (with effective dose of 75 mg/day; Kuriyan et al, ), puerh tea (with effective dose of 1,000 mg/day; Chu et al, ), I. gabonensis (with effective dose of 300 mg/day; Ngondi et al, , Ross, ), flaxseed (Cassani et al, , Saxena & Katare, ), G. cambogia (with effective dose of 2,400 mg/day; Hayamizu et al, ), E. cava (Shin et al, ), hops (Morimoto‐Kobayashi et al, ), rice bran (Hongu et al, , Ito et al, ), rapeseed (Baxheinrich et al, ), strawberries (Basu et al, ), a combination of C. quadrangularis and I. gabonensis (Oben et al, ), and a combination of ma huang and kola nut (Coffey, Steiner, Baker, & Allison, ). Other plants that have been affected by decreased LDL are detailed in Table S6.…”

Section: Discussionmentioning

confidence: 99%

“…gabonensis (Ngondi et al, 2009;Ross, 2011), P. vulgaris (Hartman et al, 2011), G. ambogia (Preuss et al, 2004), rapeseed oil ( Hayamizu et al, 2003), E. cava (Shin et al, 2012), hops (Morimoto-Kobayashi et al, 2016), rice bran (Hongu et al, 2014, Ito et al, 2015, rapeseed (Baxheinrich et al, 2012), strawberries , a combination of C. quadrangularis and I. gabonensis (Oben et al, 2008), and a combination of ma huang and kola nut (Coffey, Steiner, Baker, & Allison, 2004). Other plants that have been affected by decreased LDL are detailed in Table S6.…”

Section: Leptinmentioning

confidence: 99%

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Payab

Hasani‐Ranjbar

Shahbal

et al. 2019

Phytotherapy Research

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Obesity is a medical situation in which excess body fat has gathered because of imbalance between energy intake and energy expenditure. In spite of the fact that the variety of studies are available for obesity treatment and management, its “globesity” still remains a big challenge all over the world. The current systematic review and meta‐analysis aimed to evaluate the efficacy, safety, and mechanisms of effective herbal medicines in the management and treatment of obesity and metabolic syndrome in human. We systematically searched all relevant clinical trials via Web of Science, Scopus, PubMed, and the Cochrane database to assess the effects of raw or refined products derived from plants or parts of plants on obesity and metabolic syndrome in overweight and obesity adult subjects. All studies conducted by the end of May 2019 were considered in the systematic review. Data were extracted independently by two experts. The quality assessment was assessed using Consolidated Standards of Reporting Trials checklist. The main outcomes were anthropometric indices and metabolic syndrome components. Pooled effect of herbal medicines on obesity and metabolic syndrome were presented as standardized mean difference (SMD) and 95% confidence interval (CI). A total of 279 relevant clinical trials were included. Herbals containing green tea, Phaseolus vulgaris, Garcinia cambogia, Nigella sativa, puerh tea, Irvingia gabonensis, and Caralluma fimbriata and their active ingredients were found to be effective in the management of obesity and metabolic syndrome. In addition, C. fimbriata, flaxseed, spinach, and fenugreek were able to reduce appetite. Meta‐analysis showed that intake of green tea resulted in a significant improvement in weight ([SMD]: −0.75 [−1.18, −0.319]), body mass index ([SMD]: −1.2 [−1.82, −0.57]), waist circumference ([SMD]: −1.71 [−2.66, −0.77]), hip circumference ([SMD]: −0.42 [−1.02, −0.19]), and total cholesterol, ([SMD]: −0.43 [−0.77, −0.09]). In addition, the intake of P. vulgaris and N. sativa resulted in a significant improvement in weight ([SMD]: −0.88, 95 % CI: [−1.13, −0.63]) and triglyceride ([SMD]: −1.67, 95 % CI: [−2.54, −0.79]), respectively. High quality trials are still needed to firmly establish the clinical efficacy of the plants in obesity and metabolic syndrome.

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“…The anti-obesity effects of MHBAs in humans were investigated in a randomized, double-blind, placebo-controlled study [56,57]. Two-hundred subjects (aged 20-65 years) with BMIs of 25-30 kg/m 2 were randomly assigned to two groups and treated with MHBAs (35 mg/kg) or placebo for 12 weeks.…”

Section: Mhbas Improve Lipid Metabolism and Obesity-induced Cognitivementioning

confidence: 99%

Improving Effects of Hop-Derived Bitter Acids in Beer on Cognitive Functions: A New Strategy for Vagus Nerve Stimulation

2020

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Dementia and cognitive decline are global public health problems. Moderate consumption of alcoholic beverages reduces the risk of dementia and cognitive decline. For instance, resveratrol, a polyphenolic compound found in red wine, has been well studied and reported to prevent dementia and cognitive decline. However, the effects of specific beer constituents on cognitive function have not been investigated in as much detail. In the present review, we discuss the latest reports on the effects and underlying mechanisms of hop-derived bitter acids found in beer. Iso-α-acids (IAAs), the main bitter components of beer, enhance hippocampus-dependent memory and prefrontal cortex-associated cognitive function via dopamine neurotransmission activation. Matured hop bitter acids (MHBAs), oxidized components with β-carbonyl moieties derived from aged hops, also enhance memory functions via norepinephrine neurotransmission-mediated mechanisms. Furthermore, the effects of both IAAs and MHBAs are attenuated by vagotomy, suggesting that these bitter acids enhance cognitive function via vagus nerve stimulation. Moreover, supplementation with IAAs attenuates neuroinflammation and cognitive impairments in various rodent models of neurodegeneration including Alzheimer’s disease. Daily supplementation with hop-derived bitter acids (e.g., 35 mg/day of MHBAs) may be a safe and effective strategy to stimulate the vagus nerve and thus enhance cognitive function.

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Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled parallel group study

Cited by 31 publications

References 44 publications

Effect of alcohol consumption on food energy intake: a systematic review and meta-analysis

Effect of alcohol consumption on food energy intake: a systematic review and meta-analysis

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Improving Effects of Hop-Derived Bitter Acids in Beer on Cognitive Functions: A New Strategy for Vagus Nerve Stimulation

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