Mature plasma cells as indicator of better prognosis in multiple myeloma. New methodology for the assessment of plasma cell morphology

Goasguen, J; Zandecki, Marc; Mathiot, Claire; Scheiff, Jean-Marie; Bizet, Marie; Ly-Sunnaram, Béatrice; Grosbois, B.; Monconduit, M; Michaux, Jean‐Louis; Facon, Thierry

doi:10.1016/s0145-2126(99)00132-0

Cited by 48 publications

(52 citation statements)

References 9 publications

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“…In addition, an association between plasma cell maturity and survival of patients with multiple myeloma has been recognized for >50 years (27). Subtypes defined by cytologic features have numbered between two and seven in various studies (9)(10)(11)(27)(28)(29)(30)(31) but can be generalized to three: (a) low grade/well differentiated/plasmacytic; (b) intermediate grade/plasmablastic; and (c) high grade/pleiomorphic/anaplastic. We adopted the plasmacytic, plasmablastic, anaplastic system to categorize mouse plasmacytomas.…”

Section: Resultsmentioning

confidence: 99%

Anaplastic, Plasmablastic, and Plasmacytic Plasmacytomas of Mice: Relationships to Human Plasma Cell Neoplasms and Late-Stage Differentiation of Normal B Cells

Zhou²,

Lee³

et al. 2007

Cancer Research

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We have compared histologic features and gene expression profiles of newly identified plasmacytomas from NFS.V + congenic mice with plasmacytomas of IL6 transgenic, Fasl mutant, and SJL-B2M À/À mice. NFS.V + tumors comprised an overlapping morphologic spectrum of high-grade/anaplastic, intermediate-grade/plasmablastic, and low-grade/plasmacytic cases with similarities to subsets of human multiple myeloma and plasmacytoma. Microarray and immunohistochemical analyses of genes expressed by the most prevalent tumors, plasmablastic plasmacytomas, showed them to be most closely related to immunoblastic lymphomas, less so to plasmacytomas of Fasl mutant and SJL mice, and least to plasmacytic plasmacytomas of IL6 transgenic mice. Plasmablastic tumors seemed to develop in an inflammatory environment associated with gene signatures of T cells, natural killer cells, and macrophages not seen with plasmacytic plasmacytomas. Plasmablastic plasmacytomas from NFS.V + and SJL-B2M

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Section: Resultsmentioning

confidence: 99%

Anaplastic, Plasmablastic, and Plasmacytic Plasmacytomas of Mice: Relationships to Human Plasma Cell Neoplasms and Late-Stage Differentiation of Normal B Cells

Zhou²,

Lee³

et al. 2007

Cancer Research

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“…On stained bone marrow aspirates, 100 plasma cells were classified according to Greipp et al 9 We subclassified the mature and the intermediate types as lymphoplasmacytic when more than 30% plasma cells were characterized by a less abundant cytoplasm; the nuclear-to-cytoplasm ratio was less than 0.6 according to Goasguen et al 10 Morphology was reviewed in a blind fashion by 2 of us (R.G. and R.B.).…”

Section: Morphologymentioning

confidence: 99%

CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma

Robillard

Avet-Loiseau

Garand

et al. 2003

Blood

166

100

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CD20 has been reinvestigated in 66 patients with multiple myeloma (MM). Twelve of the patients (18%) expressed CD20, including 5 of 50 patients at diagnosis presenting 100% CD20 ؉ cells. Seven (58%) of 12 CD20 ؉ patients with MM had a small mature plasma cell morphology as opposed to 4 (7%) of 54 with CD20 ؊ MM (P ‫؍‬ .0001). Of note, 10 (83%) of 12 patients with CD20 ؉ MM had t(11;14) as opposed to 5 of 54 (9%) CD20 ؊ patients (P < .001). All the patients with 100% CD20 ؉ cells presented with t(11;14) and 4 of 5 with a small mature plasma cell morphology. Thus, 66% of the patients with t(11;14) expressed CD20, whereas only 4% of the 51 patients lacking such translocation expressed CD20 (P < .0001). In conclusion, CD20 expression is associated with small mature plasma cell morphology and with

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“…At least 100 PC per slide were studied by each of them. Nucleus (49 mm) and nucleolus (42 mm) were considered as large and chromatin pattern was defined as dense clumped, dispersed heterogeneous or diffuse homogeneous according to Greipp et al 1 Reduced cytoplasm was considered when nuclearcytoplasmic (N/C) ratio exceeded 0.6 according to Goasguen et al 3 Definitions of mature PC (small nucleus with clumped chromatin), intermediate PC (large nucleus or nucleolus or dispersed chromatin), immature PC (diffuse chromatin) and plasmablasts (same as immature PC but with reduced cytoplasm) were derived from Greipp et al 1,4 Mature PC with reduced cytoplasm were distinguished and termed lymphoplasmacytoid PC (LP-PC), according to Hoyer et al 8 Concordance between observers was reached in 152 cases (85%) and in all 178 cases after simultaneous re-evaluation of the discordant slides on a multihead microscope. In 18 patients, plasmablasts (X2% of all PC) were initially observed by at least one of the observers.…”

Section: Morphological Studiesmentioning

confidence: 99%

“…Indeed, both immature and plasmablastic subtypes identified patients with a poor prognosis, while those with a mature morphology experienced better survival. [1][2][3][4] However, morphological definitions differ between studies, probably because of arbitrary criteria. Recently, some chromosomal abnormalities have been shown to be powerful prognostic factors, including the chromosome 13 abnormality (C13A) and recurrent 14q32 translocations.…”

Section: Introductionmentioning

confidence: 99%

t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma

et al. 2003

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Recent studies have shown that two recurrent translocations, t(4;14)(p16;q32) and t(11;14)(q13;q32), define distinct entities with different prognosis in multiple myeloma (MM). We addressed the issue of whether these illegitimate IGH rearrangements could contribute to the morphological heterogeneity of the malignant plasma cells (PC). Bone marrow aspirates of 178 untreated MM cases with successful molecular cytogenetics analysis using fluorescence in situ hybridization were reviewed. PC of 25/48 (52%) patients with t(11;14) exhibited a lymphoplasmacytoid morphology. Moreover, 25/27 (93%) of the cases with this morphological profile bore the t(11;14). In addition, both cytogenetics and morphological subtypes shared higher incidence of nonsecretory MM. In contrast, 17 out of 28 cases (61%) with t(4;14) exhibited PC with diffuse chromatin pattern. Interestingly, both t(4;14) translocation and immature morphology correlated with higher incidence of high tumor mass and chromosome 13 abnormality. In conclusion, our results suggest that a particular morphology can be the signature of chromosomal abnormalities in MM.

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Mature plasma cells as indicator of better prognosis in multiple myeloma. New methodology for the assessment of plasma cell morphology

Cited by 48 publications

References 9 publications

Anaplastic, Plasmablastic, and Plasmacytic Plasmacytomas of Mice: Relationships to Human Plasma Cell Neoplasms and Late-Stage Differentiation of Normal B Cells

Anaplastic, Plasmablastic, and Plasmacytic Plasmacytomas of Mice: Relationships to Human Plasma Cell Neoplasms and Late-Stage Differentiation of Normal B Cells

CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma

t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma

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