Mature dendritic cell density is affected by smoking habit, lesion size, and epithelial dysplasia in oral leukoplakia samples

Souto, Giovanna Ribeiro; Matias, Michelle Danielle Porto; Nunes, Laiz Fernandes Mendes; Ferreira, Raquel Conceição; Mesquita, Ricardo Alves

doi:10.1016/j.archoralbio.2018.07.008

Cited by 12 publications

(8 citation statements)

References 39 publications

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“…Analysis and interpretation is complex, but expression has been claimed to be greater in dysplasias preceding malignant transformation than those not-progressing (Dave et al, 2020;Ries et al, 2021). However, the immune environment of dysplasia is complex and other mechanisms underlie immune surveillance including epithelial dendritic cells (Öhman et al, 2012;Pellicioli et al, 2017;Souto et al, 2018) and the frequent mutation of p53, which downregulates the innate immune response and inhibits immune surveillance (Ghosh et al, 2021). This is a complex area, research findings are often contradictory and it remains to be determined whether better analysis of the immune response in grading systems might improve predictive value.…”

Section: Dys Pl a S Ia With LI Chenoid Immune Re S P Ons Ementioning

confidence: 99%

Oral epithelial dysplasia: Recognition, grading and clinical significance

et al. 2021

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The concept of epithelial dysplasia was introduced into oral pathology over 60 years ago, following the recognition that some oral lesions had the potential to progress to oral cancer, now recognised as oral potentially malignant disorders (OPMDs). Attempts to grade oral dysplasia systematically were introduced into the literature in 1969, using photographic standards as reference (Smith et al., 1969) and internationally agreed classifications were formulated later

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Section: Dys Pl a S Ia With LI Chenoid Immune Re S P Ons Ementioning

confidence: 99%

Oral epithelial dysplasia: Recognition, grading and clinical significance

et al. 2021

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“…A peculiar aspect concerns the possibility that smoking related lesions have a different immunological pattern. Souto et al demonstrated that, in samples of oral leukoplakias, dendritic cell density decreases in the presence of smoking and increases in larger lesions and epithelial dysplasia [56]. However, Pentenero et al found that a stronger relationship of smoking with lesions in the buccal mucosa and FOM than in the tongue; this observation suggests that tissue characteristics mediate the effects of tobacco [57].…”

Section: Oral Leukoplakia: Immunopathology and Rationale For The Use mentioning

confidence: 99%

Leukoplakia and Immunology: New Chemoprevention Landscapes?

Grigolato

Bizzoca

Calabrese

et al. 2020

IJMS

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Oral potentially malignant disorders (OPMDs) comprise a range of clinical-pathological alterations frequently characterized by an architectural and cytological derangements upon histological analysis. Among them, oral leukoplakia is the most common type of these disorders. This work aims to analyze the possible use of drugs such as immunochemopreventive agents for OPMDs. Chemoprevention is the use of synthetic or natural compounds for the reversal, suppression, or prevention of a premalignant lesion conversion to malignant form. Experimental and in vivo data offer us the promise of molecular prevention through immunomodulation; however, currently, there is no evidence for the efficacy of these drugs in the chemoprevention action. Alternative ways to deliver drugs, combined use of molecules with complementary antitumor activities, diet influence, and better definition of individual risk factors must also be considered to reduce toxicity, improve compliance to the protocol treatment and offer a better individualized prevention. In addition, we must carefully reconsider the mode of action of many traditional cancer chemoprevention agents on the immune system, such as enhancing immunosurveillance and reversing the immune evasion. Several studies emphasize the concept of green chemoprevention as an alternative approach to accent healthy lifestyle changes in order to decrease the incidence of HNSCC.

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“…CD83 and CD1a were used as markers of matured DC cells in this study. 20,21 These results indicated that the differentiation of THP-1 to DC cells was significantly promoted by induction IL-4 combined with GM-CSF, while LPS treatment led to the maturation of monocyte derived DC (Mo-DC). The results of qRT-PCR showed that compared with THP-1, the expression of miR-564 in THP-1 cells was significantly elevated by IL-4 and GM-CSF, and further enhanced by LPS (Figure 3(d)).…”

Section: Resultsmentioning

confidence: 94%

“…CD83 and CD1a were used as markers of matured DC cells in this study. 20,21 These results indicated that the differentiation of THP-1 to DC cells was To investigate the effects of miR-564 on the differentiation and maturation of DC cells. miR-564 antagomir was transfected to knock down the expression of miR-564 in Mo-DC (Figure 4(a)).…”

Section: The Increased Expression Of Mir-564 Is Associated With Mo-dc Differentiation and Maturationmentioning

confidence: 99%

The high expression of miR-564 in patients with systemic lupus erythematosus promotes differentiation and maturation of DC cells by negatively regulating TP53 expression in vitro

Teng

Lin

Luan

et al. 2021

Lupus

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Background miRNA is involved in the occurrence and progression of systemic lupus erythematosus (SLE), but the regulatory effect of miRNA on dendritic cells in SLE patients is still unclear. Material and methods Bioinformatics methods were used to analyze the differentially expressed miRNA and its target genes in SLE patients. In vitro experiments were conducted to explore the effects and mechanisms of differentially expressed miRNAs in SLE patients on the differentiation and maturation of monocyte-derived dendritic cells. Results Bioinformatics analysis showed that miR-564 was up-regulated in SLE patients, and TP53 was the core target gene of miR-564. The expression level of miR-564 showed a rising trend during the differentiation and maturation of monocytes into Mo-DC cells. The differentiation, maturation and proliferation of Mo-DC cells were significantly inhibited by transfection with miR-564 antagomir. The expression of TP53 is negatively regulated by miR-564. In rescue experiments, the proliferation and migration of DC cells were significantly restored by co-transfection of miR-564 antagomir and TP53 si-RNA. Conclusion Highly expressed miR-564 promotes the maturation, proliferation of Mo-DC cells by negatively regulating the expression of TP53.

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Mature dendritic cell density is affected by smoking habit, lesion size, and epithelial dysplasia in oral leukoplakia samples

Cited by 12 publications

References 39 publications

Oral epithelial dysplasia: Recognition, grading and clinical significance

Oral epithelial dysplasia: Recognition, grading and clinical significance

Leukoplakia and Immunology: New Chemoprevention Landscapes?

The high expression of miR-564 in patients with systemic lupus erythematosus promotes differentiation and maturation of DC cells by negatively regulating TP53 expression in vitro

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