Mature cystic teratomas: Relationship between histopathological contents and clinical features

Çakmak, Bülent; Nacar, Mehmet Can; Özsoy, Zeki; Aliyev, Nurlan; Köseoğlu, Doğan

doi:10.4103/1119-3077.151051

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…In ovary, there are about 10%–20% ovarian tumors and is the most frequent germ cell tumor of the ovary. [ 7 ] They often occur in individuals of reproductive age group, between the age range of 20–40 years[ 8 ] similar to findings in the present study. Unilateral ovarian teratoma is frequently seen, whereas only 10%–15% of ovarian teratomas are bilateral.…”

Section: Discussionsupporting

confidence: 89%

Types and frequency of neural elements in mature ovarian teratomas: An 11-year study from Rural India

Dayal

Kumar

Krishna

2022

J Microsc Ultrastruct

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Introduction: Teratomas are those tumors which are derived from the totipotent cells. They may manifest at any site. Ovary is the most common site for teratomas. Ovarian teratomas may be immature and mature depending on the elements they harbor. Mature ovarian teratomas may contain ectoderm, endoderm, and mesoderm. Ectoderm mainly comprises the skin and its adnexa, followed by neural tissue, whereas mesodermal elements are blood vessels, adipose tissue, cartilage, and hematopoietic tissue, similarly, endoderm consists of respiratory tissue, thyroid gland, and gastrointestinal tissue. Materials and Methods: This study was conducted in the histopathology section from January 2008 to April 2019 and included 54 cases of mature ovarian teratomas. The slides of ovarian tumors were evaluated, and the relationship between clinical and pathological findings was studied with emphasis predominantly on neural elements. Results: The most common age group among the women with ovarian teratoma was 21–30 (31.48%) years, the youngest patients been 8 years, and oldest of 60 years. The chief complaints were pain in 37 (68.51%), followed by mass per abdomen 25 (46.29%). On gross examination, most of the tumors were unilateral 53 (98.14%), having tufts of hairs with sebaceous material 34 (61.81%). Microscopic examination confirmed the presence of squamous epithelium and its adnexal structure 52 (94.54%). Neural elements were seen in 14 (25.45%) cases. In every case with neural elements, skin, its adnexa, and adipose tissue were also seen. Conclusion: Teratomas have diversity in the age of presentation, gross findings, and microscopy features. Neural elements are commonly found in 25.45% of ovarian teratoma which is mostly found in association with skin and adipose tissue. The combination of neural elements with adipose tissue signifies an association between them because both arise from different dermal elements.

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Section: Discussionsupporting

confidence: 89%

Types and frequency of neural elements in mature ovarian teratomas: An 11-year study from Rural India

Dayal

Kumar

Krishna

2022

J Microsc Ultrastruct

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“…Six studies were excluded from tabulation and analysis after reading the full text [13,[18][19][20][21][22]. Among them, three were excluded due to insufficient data [18][19][20][21]. Finally, Sagi-Dain et al…”

Section: Excluded Studiesmentioning

confidence: 99%

“…included patients with benign diseases and did not report separate outcomes for those with MCT whereas Wang et al enrolled only patients with torsion in their study group and were both excluded [13][14][15][16][17][18][19][20][21][22].…”

Section: Excluded Studiesmentioning

confidence: 99%

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Prodromidou¹,

Pandraklakis²,

Loutradis³

et al. 2019

Cureus

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The role of preoperative CA 19-9 levels in patients with ovarian mature cystic teratoma (MCT) and the association of elevated levels of the biomarker with patients' and tumor characteristics were evaluated. Four electronic databases were searched for articles published up to September 2019. Trials that evaluated the significance of elevated CA 19-9 in patients with ovarian MCTs and publications with > 20 patients were considered eligible for inclusion. Seven studies that included 995 patients with an ovarian MCT who were evaluated with elevated (n = 364) or normal (n = 631) CA 19-9 levels were included. Mean tumor size was significantly increased in patients with elevated CA 19-9 levels (p = 0.038). The rate of ovarian torsion was significantly increased in the elevated CA 19-9 group (p = 0.04). The present study highlights the importance of CA 19-9 as a marker in the diagnosis of MCT, and a meta-analysis supports that it could raise a high degree of clinical suspicion of early recognition of torsion and early surgical management due to complications related to increased size. Nonetheless, the diagnostic value of CA 19-9 is still limited and CA 19-9 can still serve only as a supplementary diagnostic tool in patients with MCTs.

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Repeated pregnancy with concomitant presence of ovarian teratoma: A case report and literature review

Chen¹,

Chang²,

Huang³

et al. 2017

Taiwanese Journal of Obstetrics and Gynecology

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Younger patients and patients with bilateral or large size dermoid cysts should be followed up closely. Further studies are needed for better understanding of its natural clinical course and the mechanism of progression. The treatment options should be made individually, weighing the risks of torsion, rupture, or obstruction of labor versus the potential for unnecessary surgical risk to mother and fetus.

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Mature cystic teratomas: Relationship between histopathological contents and clinical features

Abstract: Our findings suggest no relationship between the clinical features and histopathological contents of MCTs.

Cited by 4 publications

References 23 publications

Types and frequency of neural elements in mature ovarian teratomas: An 11-year study from Rural India

Types and frequency of neural elements in mature ovarian teratomas: An 11-year study from Rural India

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Repeated pregnancy with concomitant presence of ovarian teratoma: A case report and literature review

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