Mature cystic teratoma of the neck misdiagnosed at cystic hygroma; Case report

Hassan, Hassan Muhsen; Omar, Asaad Shareef; Mohammed, Ayad Ahmad

doi:10.1016/j.ijscr.2020.12.062

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Although, physical examination and preoperative radiological investigation cannot establish the final diagnosis, ultrasound may help to reveal the size, composition and detect any cystic components inside the tumor, and Computed Tomography ( CT ) scan is more useful to show the anatomical details including; extent of teratoma, its relationship to the surrounding organs, and cyst-wall evaluation [6] , [8] . Furthermore, even with the present-day high-resolution imaging techniques, congenital cystic teratoma of the head and neck is sometimes difficult to distinguish from cystic hygroma [9] .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, even with the present-day high-resolution imaging techniques, congenital cystic teratoma of the head and neck is sometimes difficult to distinguish from cystic hygroma [9] . Even though, squamous cells obtained by fine needle aspiration ( FNA ) which is a minimally invasive procedure aimed to take cellular samples for diagnostic purposes could give the suspicion of the dysembriogenic nature of the lesion, the definite diagnosis of teratoma is based on the surgery and histopathologic examination [8] , [10] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Congenital mature cystic teratoma of the parotid gland in an infant: Report of a unique case

Hanifi¹,

Baset²,

Ibrahimkhil³

et al. 2023

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Congenital mature cystic teratoma of the parotid gland in an infant: Report of a unique case

Hanifi¹,

Baset²,

Ibrahimkhil³

et al. 2023

International Journal of Surgery Case Reports

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“…Unlike mature teratomas, immature teratomas have the potential for recurrence and metastasis. Therefore, they can be localized anywhere except in the limbs and lymph nodes [20]. Pashankar F et al have shown that postoperative chemotherapy is standard in immature teratoma disease [21].…”

Section: Discussionmentioning

confidence: 99%

Distinctive Clinical and Pathologic Features of Immature Teratomas Arising from Induced Pluripotent Stem Cell Injection in a Patient with type 2 Diabetes: A Case Report

Han

Hao

Yang

et al. 2021

Preprint

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Background: As a new potential cure for diabetes, induced pluripotent stem cells (iPSCs) are characterized by self-renewal capacity and the ability to differentiate into pancreatic islet β-cells, which will hopefully secrete insulin and rebuild blood glucose balance. The safety and validity of iPSC treatment for diabetes remain controversial. One of the most serious risks is teratoma formation arising from undifferentiated stem cells, but clinical reports are rare.Case presentation: Here, we report a distinctive case of immature teratoma after iPSC treatment for diabetes, which was accidentally treated in our soft tissue sarcoma centre. The patient received islet β-cell injection, in which the cells were differentiated from autologous iPSCs, into the deltoideus muscle. Two months later, a mass located in the injection area formed with enlarged axillary lymph nodes. Here, we present the different clinical, radiological and pathological features of this immature teratoma in detail. Distinctive from typical immature teratomas, the tumour was characterized by rapid growth and local lymph node metastasis. The tumour was not sensitive to typical chemotherapy regimens for immature teratomas. MRI scanning showed heterogeneous enhancement and a rich blood supply to the tumour. The histopathology showed immature endoderm, mesoderm and ectoderm tissues composed of osseous, cartilaginous, vascular and adenoid tissues, which have more cellular atypia than typical teratomas. Staining for both Oct-4 and Sox-2 was positive in the tumour cell nucleus by immunofluorescence assay, but insulin staining was negative. Next-generation sequencing showed many missense mutations, but abnormal gene rearrangement or copy number was not observed.Conclusions: More attention should be given to teratoma formation after iPSC treatment for diabetes, which is more aggressive than typical teratomas. The safety and validity of iPSC treatment for diabetes should be confirmed by more standardized clinical trials.

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“…This can be attributed to the lack of appropriate antenatal screening scans. During a review of the literature, we found a similar case where a patient was misdiagnosed as a case of cystic hygroma, and sclerotherapy was performed as a primary intervention, but no response to therapy pointed towards an alternative diagnosis [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Cervical Cystic Teratoma: An Unusual Cause of Airway Obstruction in the Pediatric Population

Azam¹,

Hanif²,

Khan³

et al. 2021

Cureus

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Cystic teratoma is a germ cell tumor, which usually involves the gonads. However, it can be located occasionally in other organs. The most common extragonadal sites for germ cell tumors include midline structures such as the retroperitoneum, mediastinum, pineal body, and supra-sellar space. Here, we describe a case of a patient who presented with a cystic teratoma involving the anterior aspect of the neck. The chief complaints of the patient consisted of a large swelling in front of the neck, difficulty in breathing, and frequent regurgitation of milk during feeding. Initially, a diagnosis of cystic hygroma was instituted for which the patient underwent sclerotherapy utilizing bleomycin. However, no improvement was observed in the patient’s condition. A detailed evaluation was planned, starting with a CT scan of the head and neck that suggested cystic teratoma as the likely etiology. Surgical excision of the mass was performed, and an excisional biopsy for histopathological examination was taken. A final diagnosis of cervical cystic teratoma was established based on the histopathological findings. The purpose of reporting this case is to raise awareness among fellow healthcare professionals that cystic teratoma can also present with a large swelling in the anterior neck with obstructive features.

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Mature cystic teratoma of the neck misdiagnosed at cystic hygroma; Case report

Cited by 4 publications

References 14 publications

Congenital mature cystic teratoma of the parotid gland in an infant: Report of a unique case

Congenital mature cystic teratoma of the parotid gland in an infant: Report of a unique case

Distinctive Clinical and Pathologic Features of Immature Teratomas Arising from Induced Pluripotent Stem Cell Injection in a Patient with type 2 Diabetes: A Case Report

Cervical Cystic Teratoma: An Unusual Cause of Airway Obstruction in the Pediatric Population

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