Mature CD10+ and immature CD10− neutrophils present in G-CSF–treated donors display opposite effects on T cells

Marini, Olivia; Costa, Sara; Bevilacqua, Dalila; Calzetti, Federica; Tamassia, Nicola; Spina, Cecilia; Sabata, D. De; Tinazzi, Elisa; Lunardi, Claudio; Scupoli, Maria Teresa; Cavallini, Chiara; Zoratti, Elisa; Tinazzi, Ilaria; Marchetta, Antonio; Vassanelli, A.; Cantini, Maurizio; Gandini, Giorgio; Ruzzenente, Andrea; Guglielmi, Alfredo; Missale, Francesco; Vermi, William; Tecchio, Cristina; Cassatella, Marco A.; Scapini, Patrizia

doi:10.1182/blood-2016-04-713206

Cited by 257 publications

(337 citation statements)

References 62 publications

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“…Using samples from patients receiving G‐CSF treatment, they noted that both CD10 + mature neutrophil populations (HDN and LDN) display T cell suppressive activity, which is in contrast to the CD10 − immature population that promoted T cell proliferation and cytokine release. They further validated the CD10 + marker in cancer and SLE patients and noted a higher proportion of mature neutrophils (CD10 + ) to immature neutrophils (CD10 − ) amongst LDNs from cancer patients compared with patients suffering from autoimmunity . These data suggested that maybe the distribution of cells in the LDN fraction may dictate the overall function of this compartment, however further validation is needed to substantiate this view.…”

Section: Neutrophil Populations In Inflammatory Settingsmentioning

confidence: 91%

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Neutrophil heterogeneity: Bona fide subsets or polarization states?

Deniset

Kubes

2018

Journal of Leukocyte Biology

116

118

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Neutrophils are key components of the innate immune system that play important roles during infection, injury, and chronic disease. In recent years, neutrophil heterogeneity has become an emerging focus with accumulating evidence of neutrophil populations with distinct functions under both steady-state and pathologic conditions. Despite these advances, it remains unclear whether these different populations represent bona fide subsets or simply activation/polarization states in response to local cues. In this review, we summarize the varied neutrophils populations that have been described under both basal and during inflammation. We discuss the evidence that supports the existence of neutrophils subsets. Finally, we identify potential gaps in our knowledge that may further advance our current understanding of neutrophil heterogeneity.

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Section: Neutrophil Populations In Inflammatory Settingsmentioning

confidence: 91%

“…These populations can be further identified by a collection of cell surface markers. In humans, immature neutrophils start to express CD15 and CD11b, followed by an elevation in CD16 and CD10 to reach full maturity . In the mouse system, Kim et al .…”

Section: Introductionmentioning

confidence: 99%

Neutrophil heterogeneity: Bona fide subsets or polarization states?

Deniset

Kubes

2018

Journal of Leukocyte Biology

116

118

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“…T cell‐suppressing neutrophils mobilized 5 days after G‐CSF mobilization have a high expression of CD10 . As yet, it is unclear whether both suppressing neutrophils belong to the same phenotype or that cells mobilized for 3 hours by endotoxin or 5 days by G‐CSF belong to different phenotypes.…”

Section: The Neutrophil In Immune Regulationmentioning

confidence: 99%

Neutrophil phenotypes in health and disease

Hellebrekers

Vrisekoop

Koenderman

2018

Eur J Clin Investigation

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Neutrophils are one of the most important effector cells of the innate immune response (1). They are traditionally seen as a homogenous population of short‐lived cells mainly involved in the defence against extracellular microorganisms by phagocytosis and intracellular killing (1,2). The cells contain a large armamentarium that aids in this function and ranges from the production of reactive oxygen species by a membrane‐bound NADPH oxidase to cytotoxic proteins and peptides residing in the different granules present in the cytoplasm (3). Recently, the view of neutrophils belonging to a homogenous population of cells has been challenged, and several neutrophil phenotypes have been described that exhibit specialized functions, such as involvement in tissue repair, tumour killing and immune regulation (4). It is not clear whether these cells belong to separate parallel lineages originating from the bone marrow or that neutrophils become instructed in the distant tissues, thus changing their phenotypes. In addition, functional heterogeneity in a phenotypically homogenous population of neutrophils adds to the complexity of neutrophil phenotypes(5). This article will review the current literature describing the heterogeneity within the neutrophil compartment with respect to both phenotype and function in health and disease.

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“…In general, a high blood NLR is associated with poor prognosis in many different types of cancers, as elevated levels of circulating neutrophils are an indicator of cancer‐related systemic inflammation . Even immature neutrophils are found to accumulate in the circulation of cancer patients, suggesting tumor‐driven alterations of myelopoiesis and a derailed balance of neutrophil retention and release from the bone marrow …”

Section: Neutrophil Abundance and Cancer Prognosismentioning

confidence: 99%

Getting TANned: How the tumor microenvironment drives neutrophil recruitment

SenGupta

Subramanian

Parent

2018

Journal of Leukocyte Biology

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The directed migration of neutrophils to sites of injury or infection is mediated by complex networks of chemoattractant‐receptor signaling cascades. The recent appreciation of neutrophils as active participants in tumor progression and metastasis has drawn attention to a number of chemokine‐receptor systems that may drive their recruitment to tumors. However, the dynamic nature of the tumor microenvironment (TME) along with the phenotypic diversity among tumor‐associated neutrophils (TANs) call for a more comprehensive approach to understand neutrophil trafficking to tumors. Here, we review recent advances in understanding how guidance cues underlie neutrophil migration to primary and secondary tumor sites. We also discuss how the presence of other myeloid cells, such as functionally diverse subsets of tumor‐associated macrophages (TAMs), can further influence neutrophil accumulation in tumors. Finally, we highlight the importance of hypoxia sensing in localizing TAMs and TANs in the tumor niche and provide a cohesive view on how both myeloid cell types shape TME‐associated extracellular matrix organization, which in turn contribute to tumor progression.

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Mature CD10+ and immature CD10− neutrophils present in G-CSF–treated donors display opposite effects on T cells

Abstract: Key Points CD10 as a marker discriminating mature from immature neutrophils within heterogeneous neutrophil populations in pathological settings. Immunosuppressive mature CD66b+CD10+ and immunostimulatory immature CD66b+CD10− neutrophils coexist in G-CSF–treated donors.

Cited by 257 publications

References 62 publications

Neutrophil heterogeneity: Bona fide subsets or polarization states?

Neutrophil heterogeneity: Bona fide subsets or polarization states?

Neutrophil phenotypes in health and disease

Getting TANned: How the tumor microenvironment drives neutrophil recruitment

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