Mature and Immature Extracranial Teratomas in Children: The UK Children's Cancer Study Group Experience

Mann, J R; Gray, Elizabeth; Thornton, Claire M.; Raafat, F.; Robinson, K.; Collins, Gary S.; Gornall, P.; Huddart, Simon; Hale, Juliet; Oakhill, A.

doi:10.1200/jco.2008.16.0622

Cited by 137 publications

(150 citation statements)

References 14 publications

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“…Long follow-up studies have demonstrated its benign course (Fortt et al, 1969;Robboy et al, 1970). A recent study comparing ovarian immature teratomas with and without GP demonstrated a similar overall good survival but with a higher incidence of early recurrences in the cases associated with GP (Mann et al, 2008;Yoon et al, 2012). Occasionally, GP may precede highly malignant neuroectodermal tumours (Dadmanesh et al, 1997;Shefren et al, 1991;Trabelsi et al, 2002).…”

Section: Clinical Featuresmentioning

confidence: 95%

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Gliomatosis peritonei as a natural experiment in tissue differentiation

Nogales¹,

Preda²,

Dulcey³

2012

Int. J. Dev. Biol.

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Gliomatosis peritonei (GP) is an unusual condition in which nodules of mature astroglia, often miliary and microscopic in size, are widespread in the peritoneum and abdominal lymph nodes. Its behaviour is benign and it is usually found in association with ovarian teratoma and rarely with teratomas of other organs. Implants grow rapidly and can remain unchanged for life. Astroglia is the main component, but other neural lineage elements and many other tissues can be found. Cells are mature but not terminal, since they express SOX2. Secondary associated lesions include: a) degenerative astrocytic changes, b) granulomatous and follicular chronic inflammatory changes, c) association with hormonally related changes, such as decidual peritoneal metaplasia and endometriosis and d) endothelial and adventitial vascular hyperplasia leading to haemoperitoneum. Two pathogenetic mechanisms are considered: direct seeding of immature neural cells from a primary tumour with subsequent differentiation and metaplasia from peritoneal stem cells. The former proposal is supported by clinicopathologic data such as ample cellular heterogeneity, coexistence of mature astroglia with neural blastema, as well as the shed keratin and hairs from the ovarian neoplasm. However, metaplasia is sustained by a heterozygosity pattern of GP nodules, identical to the normal tissue and different from the coexistent ovarian teratoma. GP would constitute a response to growth factors from teratoma or macrophages. While an implantative origin from ovarian teratoma remains in most cases a more probable mechanism, metaplasia from peritoneal stem cells would explain cases of GP which present a monomorphic astrocytic cell population.

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Section: Clinical Featuresmentioning

confidence: 95%

“…GP involvement of lymph nodes (Heifetz et al, 1998;Mann et al, 2008;Muller et al, 2002) is often an incidental finding in abdominal lymphadenectomy specimens, occurring in the marginal sinus (Fig 3B). Secondary associated lesions in GP may include the following:…”

Section: Gliomatosis Peritonei (Gp) (Arrow) Is Present In the Marginamentioning

confidence: 99%

Gliomatosis peritonei as a natural experiment in tissue differentiation

Nogales¹,

Preda²,

Dulcey³

2012

Int. J. Dev. Biol.

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“…Excision of the primary tumour and coccyx should be done in all cases even if a CR has been documented . Recently, Mann et al [14] reported data from the UK Children's Cancer Study group experience. They reported that poor outcome was related to incomplete resection, tunour rupture and higher stage and grade.…”

Section: Discussionmentioning

confidence: 97%

Long-term outcomes of surgery for malignant sacrococcygeal teratoma: 20-year experience of a regional UK centre

et al. 2009

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“…According to a series, sacrococcygeal teratomas presented at birth or infancy, ovarian between 5-15 years, testicular before 5 years of age, thoracic tumors occurred throughout infancy and childhood while teratomas at other sites occurred mainly during infancy [5] . Similar results were documented in the present study.…”

Section: Discussionmentioning

confidence: 99%