Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents

Madsen, Kathrine Skak; Johansen, Louise Baruël; Thompson, Wesley K.; Siebner, Hartwig R.; Jernigan, Terry L.; Baaré, William F.C.

doi:10.1016/j.neuroimage.2020.117105

Cited by 16 publications

(28 citation statements)

References 55 publications

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“…Highest level of maternal and paternal education was transformed into years of education using national norms and used to estimate average years of parental education for all participants (mean = 13.8, SD = 2.0). Data from the HUBU cohort has previously been used in cross-sectional (Angstmann et al, 2016;Gonzalez et al, 2021;Klarborg et al, 2013;Madsen et al, 2011;Madsen et al, 2010;Madsen et al, 2018;Vestergaard et al, 2011) and longitudinal (Madsen et al, 2020) studies examining brainbehavioral relationships. Assessments including MRI and the Junior Eysenck Personality Questionnaire (J-EPQ, in the present study only neuroticism scores were used -see text) are shown as closed circles, MRI only as open circles, and J-EPQ only as "x".…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…We used the default thin plate regression splines smoothing function to fit the data with default penalizing parameters. Further, we used five knots (k), representing the k-1 number of basis functions used to generate the smooth function, as we previously have shown that this reduces the risk of overfitting (Madsen et al, 2020). The smoothing parameters were estimated with the restricted maximum likelihood method (REML).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Finally, for each subject we estimated movement during DWI scanning by calculating the root mean square deviation (RMS) of the six rigid body transformation parameters resulting from co-registering DWI images to the mean b0 image (Jenkinson & Smith, 2001;Taylor et al, 2016), using a spherical volume radius of 60 mm to approximate the brain." (Madsen et al, 2020).…”

Section: Construction Of the Diffusion Tensor Imagesmentioning

confidence: 99%

“…Fractional anisotropy (FA), axial diffusivity (AD = λ1) and radial diffusivity (RD = (λ2 + λ3) / 2) images were created. Finally, non-brain voxels in FA and diffusivity images were removed by employing a brain mask based on warped b0 images" (Madsen et al, 2020).…”

Section: Spatial Normalization Of the Longitudinal Diffusion Tensor Imagesmentioning

confidence: 99%

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Only females show a stable association between neuroticism and microstructural asymmetry of the cingulum across childhood and adolescence: A longitudinal DTI study

Plachti

Baaré

Johansen

et al. 2021

Preprint

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Neuroticism is characterized by a tendency to experience negative and anxious emotions. This personality trait is linked to an increased risk of anxiety and mood disorders. In a cross-sectional 3T diffusion tensor imaging (DTI) study in children and adolescents, we found an association between neuroticism and a relative imbalance between left and right (i.e., asymmetry) fractional anisotropy (FA) in the cingulum and white matter underlying the ventromedial prefrontal cortex with opposite directions in females and males. Here we analyzed the longitudinal follow-up DTI data, which was acquired in 76 typically-developing 7- to 18-year-olds, including up to 11 scans per subject. Neuroticism was assessed up to four times. Our longitudinal DTI measurements substantiate robust associations between higher neuroticism scores and increased left relative to right cingulum FA in females and decreased left relative to right cingulum FA in males. In females, the association was already present in late childhood and with a stable expression across childhood and adolescence. In males, the association gradually emerged during adolescence. Future longitudinal studies should clarify which neurobiological factors (e.g., genetic variation, prenatal stress, sex hormones) contribute to the sex-specific associations in the relationship between neuroticism and interhemispheric microstructural asymmetry of the cingulum.

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Section: Study Design and Participantsmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Construction Of the Diffusion Tensor Imagesmentioning

confidence: 99%

Section: Spatial Normalization Of the Longitudinal Diffusion Tensor Imagesmentioning

confidence: 99%

See 2 more Smart Citations

Only females show a stable association between neuroticism and microstructural asymmetry of the cingulum across childhood and adolescence: A longitudinal DTI study

Plachti

Baaré

Johansen

et al. 2021

Preprint

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“…Response inhibition has been demonstrated to undergo continuous improvement throughout early childhood and adolescence ( Bedard et al, 2002 , Curley et al, 2018 , Dupuis et al, 2019 , Madsen, 2010 , Madsen et al, 2020 , Williams et al, 1999 ). Prior developmental work in healthy children has shown rapid decreases in SSRT during early childhood, reaching a peak in adolescence before plateauing ( Curley et al, 2018 , Madsen et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal developmental trajectories of inhibition and white-matter maturation of the fronto-basal-ganglia circuits

Singh

Skippen

et al. 2022

Developmental Cognitive Neuroscience

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Stability of associations between neuroticism and microstructural asymmetry of the cingulum during late childhood and adolescence: Insights from a longitudinal study with up to 11 waves

Plachti

Baaré

Johansen

et al. 2022

Human Brain Mapping

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Adolescence is characterized by significant brain development and marks a period of the life span with an increased incidence of mood disorders, especially in females. The risk of developing mood disorders is also higher in individuals scoring high on neuroticism, a personality trait characterized by a tendency to experience negative and anxious emotions. We previously found in a cross‐sectional study that neuroticism is associated with microstructural left–right asymmetry of the fronto‐limbic white matter involved in emotional processing, with opposite effects in female and male adolescents. We now have extended this work collecting longitudinal data in 76 typically developing children and adolescents aged 7–18 years, including repeated MRI sampling up to 11 times. This enabled us, for the first time, to address the critical question, whether the association between neuroticism and frontal‐limbic white matter asymmetry changes or remains stable across late childhood and adolescence. Neuroticism was assessed up to four times and showed good intraindividual stability and did not significantly change with age. Conforming our cross‐sectional results, females scoring high on neuroticism displayed increased left–right cingulum fractional anisotropy (FA), while males showed decreased left–right cingulum FA asymmetry. Despite ongoing age‐related increases in FA in cingulum, the association between neuroticism and cingulum FA asymmetry was already expressed in females in late childhood and remained stable across adolescence. In males, the association appeared to become more prominent during adolescence. Future longitudinal studies need to cover an earlier age span to elucidate the time point at which the relationship between neuroticism and cingulum FA asymmetry arises.

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Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents

Cited by 16 publications

References 55 publications

Only females show a stable association between neuroticism and microstructural asymmetry of the cingulum across childhood and adolescence: A longitudinal DTI study

Only females show a stable association between neuroticism and microstructural asymmetry of the cingulum across childhood and adolescence: A longitudinal DTI study

Longitudinal developmental trajectories of inhibition and white-matter maturation of the fronto-basal-ganglia circuits

Stability of associations between neuroticism and microstructural asymmetry of the cingulum during late childhood and adolescence: Insights from a longitudinal study with up to 11 waves

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