Maturational phase of hippocampal neurogenesis and cognitive flexibility

Webler, Ryan; Fulton, Sasha L.; Perera, Tarique D.; Coplan, Jeremy D.

doi:10.1016/j.neulet.2019.134414

Cited by 10 publications

(10 citation statements)

References 38 publications

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“…A recent study reported that immature new neurons (DCX + without tertiary dendrites) are more likely implicated in tasks that demand cognitive flexibility than mature new neurons ( Webler et al, 2019 ). Several lines of research indicate that immature new neurons may contribute to cognitive flexibility by enhancing the inhibitory tone in the DG-CA3 circuit to reduce the proactive interference between two similar experiences (i.e., old and new platform location) which is important to improve memory resolution ( Kempermann, 2008 ; McAvoy et al, 2015 ; Besnard and Sahay, 2016 ; Berdugo-Vega et al, 2021 ).…”

Section: The Morris Water Mazementioning

confidence: 99%

Morris Water Maze and Contextual Fear Conditioning Tasks to Evaluate Cognitive Functions Associated With Adult Hippocampal Neurogenesis

Hernández-Mercado

Zepeda

2022

Front. Neurosci.

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New neurons are continuously generated and functionally integrated into the dentate gyrus (DG) network during the adult lifespan of most mammals. The hippocampus is a crucial structure for spatial learning and memory, and the addition of new neurons into the DG circuitry of rodents seems to be a key element for these processes to occur. The Morris water maze (MWM) and contextual fear conditioning (CFC) are among the most commonly used hippocampus-dependent behavioral tasks to study episodic-like learning and memory in rodents. While the functional contribution of adult hippocampal neurogenesis (AHN) through these paradigms has been widely addressed, results have generated controversial findings. In this review, we analyze and discuss possible factors in the experimental methods that could explain the inconsistent results among AHN studies; moreover, we provide specific suggestions for the design of more sensitive protocols to assess AHN-mediated learning and memory functions.

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Section: The Morris Water Mazementioning

confidence: 99%

Morris Water Maze and Contextual Fear Conditioning Tasks to Evaluate Cognitive Functions Associated With Adult Hippocampal Neurogenesis

Hernández-Mercado

Zepeda

2022

Front. Neurosci.

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“…Interestingly, while spatial memory performance positively correlates with the level of AHN [ 64 , 65 , 66 ], it appears that a learning task such as the water maze influences the level of AHN [ 67 , 68 ]. Therefore, we separated our mice into two cohorts: mice that went through the water maze were not used for other behavioral tests than the TST to avoid any side effects of learning-induced increased neurogenesis on other behavioral tasks.…”

Section: Discussionmentioning

confidence: 99%

Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression

Planchez

Lagunas

Guisquet

et al. 2021

Cells

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Many studies evaluated the functional role of adult hippocampal neurogenesis (AHN) and its key role in cognitive functions and mood regulation. The effects of promoting AHN on the recovery of stress-induced symptoms have been well studied, but its involvement in stress resilience remains elusive. We used a mouse model enabling us to foster AHN before the exposure to unpredictable chronic mild stress (UCMS) to evaluate the potential protective effects of AHN on stress, assessing the depressive-like phenotype and executive functions. For this purpose, an inducible transgenic mouse model was used to delete the pro-apoptotic gene Bax from neural progenitors four weeks before UCMS, whereby increasing the survival of adult-generated neurons. Our results showed that UCMS elicited a depressive-like phenotype, highlighted by a deteriorated coat state, a higher immobility duration in the tail suspension test (TST), and a delayed reversal learning in a water maze procedure. Promoting AHN before UCMS was sufficient to prevent the development of stressed-induced behavioral changes in the TST and the water maze, reflecting an effect of AHN on stress resilience. Taken together, our data suggest that increasing AHN promotes stress resilience on some depressive-like symptoms but also in cognitive symptoms, which are often observed in MD.

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“…to increase dendritic complexity of immature neurons 72 . While it is known that younger neural progenitor cells mediate pattern separation 73 , it has also been demonstrated that less morphologically complex immature DCX cells may be more important for pattern separation and cognitive flexibility than more mature DCX cells and GC neurons (BrdU + NeuN + ) 74 . Additional factors likely of relevance include the fact that C3aR is also part of a signalling pathway that mediates synaptic strength 75,76 which likely influences the synaptic connectivity both within and beyond the neurogenic niche, consistent with evidence of altered cognition in C3aR -/mice from a variety of contexts 26,39,77,78 .…”

Section: Discussionmentioning

confidence: 99%

Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice

Westacott

Haan

Evison

et al. 2021

Brain, Behavior, and Immunity

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Maturational phase of hippocampal neurogenesis and cognitive flexibility

Cited by 10 publications

References 38 publications

Morris Water Maze and Contextual Fear Conditioning Tasks to Evaluate Cognitive Functions Associated With Adult Hippocampal Neurogenesis

Morris Water Maze and Contextual Fear Conditioning Tasks to Evaluate Cognitive Functions Associated With Adult Hippocampal Neurogenesis

Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression

Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice

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