Maturation of the oral microbiota during primary teeth eruption: a longitudinal, preliminary study

He, Xing; Tian, Bijun; Shi, Weihua; Tian, Jing; Wang, Wenjun; Qin, Man

doi:10.1080/20002297.2022.2051352

Cited by 10 publications

(13 citation statements)

References 37 publications

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“…Firstly, the different dentition situation between maternal oral cavity and neonatal oral cavity. A study had showed that the tooth eruption affected the composition of the oral microbiome, and the relative abundance of Streptococcus was over 60% during the pre-dentate period while sharply decreased with the eruption of the primary incisors ( Xu et al, 2022 ). Secondly, the huge age difference between mothers and neonates also induced the difference, and studies had found that some bacteria were less abundant at older ages ( Huang et al, 2020 ; Schwartz et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The dynamic communities of oral microbiome in neonates

Guo

Yao

et al. 2022

Front. Microbiol.

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The oral microbiome, associated with both oral disease and systemic disease, is in dynamic status along the whole life, and many factors including maternal microbiomes could impact the oral microbiome. While fewer studies have been conducted to study the characteristics of the oral microbiome in neonates and the associated maternal factors. Hence, we collected the microbiome of 15 mother-infant pairs across multiple body sites from birth up to 4 days postpartum and used high-throughput sequencing to characterize the microbiomes in mothers and their neonates. The oral microbiome in the neonates changed obviously during the 4 days after birth. Many bacteria originating from the vagina, skin, and environment disappeared in oral cavity over time, such as Prevotella bivia and Prevotella jejuni. Meanwhile, Staphylococcus epidermidis RP62A phage SP-beta, predominate bacterium in maternal skin microbiome and Streptococcus unclassified, main bacterium in vaginal microbiome, obviously increased in neonatal oral microbiome as time went on. Interestingly, as time progressed, the composition of the oral microbiome in the neonates was more similar to that of the milk microbiome in their mothers. Moreover, we found that the changes in the predominant bacteria in the neonates were in line with those in the neonates exposed to the environment. Together, these data described the sharp dynamics of the oral microbiome in neonates and the importance of maternal efforts in the development of the neonatal microbiome.

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Section: Discussionmentioning

confidence: 99%

The dynamic communities of oral microbiome in neonates

Guo

Yao

et al. 2022

Front. Microbiol.

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“…Diversity and richness is strictly connected with taxonomy. Six main phyla were found: Firmicutes , Bacteroides , Proteobacteria , Actinobacteria , Fusobacteria , and Spirochaetes [ 7 , 9 , 17 , 33 , 34 , 43 ]. The valuable work of Arweiler et al [ 18 ] pointed out a huge β-diversity in microbial abundance between plaque and saliva samples, but this was not confirmed by Nomura et al [ 26 ], who found a similar biodiversity and richness between tongue and saliva samples.…”

Section: Discussionmentioning

confidence: 99%

“… Author Year Selection Comparability Exposure Total Score Butler C.A. et al [ 7 ] 2022 3 1 3 7 Xu H. et al [ 17 ] 2022 2 1 2 5 Li F. et al [ 20 ] 2021 3 2 2 7 Lee E. et al [ 19 ] 2021 3 2 3 8 Arweiler N.B. et al [ 18 ] 2021 3 1 2 6 Xu L. et al [ 23 ] 2021 2 2 3 7 Jo R. et al [ 21 ] …”

Section: Table A1mentioning

confidence: 99%

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Exploring Oral Microbiome in Healthy Infants and Children: A Systematic Review

D’Agostino

Ferrara

Valentini

et al. 2022

IJERPH

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Recent advances in the development of next-generation sequencing (NGS) technologies, such as the 16S rRNA gene sequencing, have enabled significant progress in characterizing the architecture of the oral microbiome. Understanding the taxonomic and functional components of the oral microbiome, especially during early childhood development, is becoming critical for identifying the interactions and adaptations of bacterial communities to dynamic conditions that may lead to the dysfunction of the host environment, thereby contributing to the onset and/or progression of a wide range of pathological conditions. We aimed to provide a comprehensive overview of the most recent evidence from studies of the oral microbiome of infants and young children, focusing on the development of oral microbiome in the window of birth to 18 years, focusing on infants. A systematic literature search was conducted in PubMed, Scopus, WOS, and the WHO clinical trial website for relevant articles published between 2006 to 2022 to identify studies that examined genome-wide transcriptome of the oral microbiome in birth, early childhood, and adolescence performed via 16s rRNA sequence analysis. In addition, the references of selected articles were screened for other relevant studies. This systematic review was performed in accordance PRISMA guidelines. Data extraction and quality assessment were independently conducted by two authors, and a third author resolved discrepancies. Overall, 34 studies were included in this systematic review. Due to a considerable heterogeneity in study population, design, and outcome measures, a formal meta-analysis was not carried out. The current evidence indicates that a core microbiome is present in newborns, and it is stable in species number. Disparity about delivery mode influence are found. Further investigations are needed.

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“…Moreover, changes in the balance of the oral microbiome cause dysbiosis, which leads to a pathogenic state and the occurrence and progression of oral diseases ( Jiao et al, 2014 ). Microbial structure in the oral cavity is dependent on niche and age ( Xu et al, 2015 , 2022 ). Oral microbial maturation is triggered by age-associated biological alterations ( Crielaard et al, 2011 ), whereas oral microbial communities formed during early life can affect the long-term systemic and oral health of a child ( Dzidic et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Microbiota of preterm infant develops over time along with the first teeth eruption

Wu¹,

Feng²,

Cao³

et al. 2022

Front. Microbiol.

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ObjectiveThe temporal growth of the infant microbiome in the early years of life influences short- and long-term infant health. The aim of this longitudinal study was to investigate bacterial dynamics in the microbiome of preterm infants during tooth eruption.MethodsSaliva samples from normally delivered (n = 24) and preterm infants (n = 31) were collected 30 days after birth and after the eruption of two primary mandibular incisors. Based on Illumina MiSeq Sequencing of the 16S rRNA gene, the dynamic microbial changes of newborns at two-time points were investigated. Meanwhile, the Human Oral Microbiome Database was adopted for assigning taxonomy.ResultsUsing alpha and beta diversity analyses, different shift patterns of microbiome structures in preterm and healthy participants and bacterial diversity over time were observed. The relative abundance and shifts trend, along with the two lower primary central incisors eruption, of core oral flora varies in full-term and preterm groups, including Gemella spp., Rothia mucilaginosa, Veillonella atypica, etc. Several microorganisms colonize later in the oral microbiome development of premature babies, such as Gemella spp. In addition to teeth eruption, the growth of the saliva microbiome in preterm infants could be influenced by breastfeeding durations and birth weight.ConclusionThis study provided insights into how the oral microbiota changes during tooth eruption in preterm infants and how the colonization of the oral cavity with bacteria in preterm infants differs significantly from that in full-term infants.

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Maturation of the oral microbiota during primary teeth eruption: a longitudinal, preliminary study

Cited by 10 publications

References 37 publications

The dynamic communities of oral microbiome in neonates

The dynamic communities of oral microbiome in neonates

Exploring Oral Microbiome in Healthy Infants and Children: A Systematic Review

Microbiota of preterm infant develops over time along with the first teeth eruption

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