Maturation of nephrons by implanting hPSC-derived kidney progenitors under kidney capsules of unilaterally nephrectomized mice
xin yu,
shan Jiang,
Kailin Li
et al.
Abstract:Human pluripotent stem cell -derived kidney organoids may contribute to
disease modeling and generation of kidney replacement tissues. However,
realization of such applications requires the induction of hPSCs into
functional mature organoids. One of the key questions for this process
is whether a specific vascular system exists for nephrogenesis. Our
previous study showed that implantation of hPSC-derived organoids below
the kidney capsules of unilaterally nephrectomized mice for 2 weeks
resulted in the enlarg… Show more
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