Maturation of beta-adrenergic receptor activity of rabbit aorta and pulmonary artery

Park, Myung K.; Diehl, Antoni M.; Sunderson, John M.

doi:10.1016/0024-3205(76)90035-7

Cited by 19 publications

(13 citation statements)

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“…The 0-adrenergic mechanism has been shown to be not fully developed in newborn rabbits. Strips of pulmonary arteries and aortae from 1-to 2-day-old rabbits produced only small relaxations in response to isoproterenol but reached a maximal level by 1 month of age (4). In contrast, relaxation in response to sodium nitrite or papaverine remained constant at all ages.…”

Section: Discussionmentioning

confidence: 83%

“…Furthermore, it is widely accepted that responses of vascular smooth muscles, including that of the pulmonary artery, differ in animals of different ages. For instance, responses to vasodilators that operate through P-adrenergic receptors have been shown to increase early in development (4,5). Dopamine, therefore, may affect the pulmonary circulation of newborns and infants in a way different from that of adults.…”

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confidence: 99%

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Maturation-Related Changes in Dopamine-Induced Relaxation of Isolated Rabbit Pulmonary Artery

et al. 1988

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ABSTRACT. Studies were performed on isolated pulmonary arterial segments to investigate dopamine receptormediated relaxant effects at different times during development. Dopamine receptor-mediated relaxant effects can only be observed when vessels are precontracted with prostaglandin Fz, and in the presence of al, ag P, and serotonergic blockade. Helical strips of pulmonary arteries from rabbits of different ages (2, 7, 14, 30, and 90 days), partially precontracted by prostaglandin Fz, were tested for their responses to dopamine in the presence of prazosin M), yohimbin M), propranolol M), and methysergide M). Strips from 2-and 7-day-old rabbits were not induced to relax by dopamine, whereas those from 14-, 30-, and 90-day-old animals, after cumulative application of dopamine, underwent concentration-dependent relaxation. Dopamine (half the maximum response) concentration decreased during the development of rabbits from 14 to 90 days old. Mean values for apparent dopamine ED50 (half the maximum response) concentrations in the arteries of 14-, 30-, and 90-day old animals were 4.94 + 0.40, 2.02 + 0.30, and 0.113 + 0.028 wM, respectively.The effects of various dopamine antagonists on dopamineinduced relaxation were not markedly different at different ages. These findings indicate that dopamine receptor function is not fully developed in the pulmonary arteries of newborn rabbits, but matures as the age of the rabbit increases. (Pediatr Res 24: 160-165, 1988) Abbreviations ED50 concentration, concentration that produced half the maximum response pAz value, the negative logarithm of the molar concentration of the antagonist that produces a 2-fold shift to the right of the dose-response curve for the agonist Dopamine stimulates PI-adrenergic receptors causing positive inotropy and has been used to treat shock and congestive heart failure. In high doses, it also stimulates al-adrenergic receptors causing vasoconstriction. In low doses, however, specific dopaminergic receptors mediate vasodilation.In the cardiovascular system specific dopaminergic receptors are found in renal, mesenteric, splenic, coronary, cerebral, and femoral arteries. A vascular dopaminergic receptor classification has been proposed by Goldberg and Kohli (1, 2), in which the DA, receptor subserves smooth muscle relaxation, and the DA2 Received December 29, 1987; accepted March 18, 1988. Correspondence Dr. Miyako Mori, Department of Anesthesiology, Kobe University School of Medicine, Kusunoki-cho-7, Chuo-ku, Kobe, 650 Japan.Supported by grants from the Ministry of Education, Japan.receptor subserves the inhibition of noradrenaline release from postganglionic sympathetic nerves. Previously, we confirmed the existence of DAI dopamine receptors in the adult rabbit pulmonary artery (3). Dopamine produced a concentration-dependent relaxation of arterial strips contracted with prostaglandin F2, in the presence of prazosin (al-blocker), yohimbin (a2-blocker), propranolol (P-blocker), and methysergide (serotonin-blocker). The pulmonary circulatory system un...

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Section: Discussionmentioning

confidence: 83%

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confidence: 99%

Maturation-Related Changes in Dopamine-Induced Relaxation of Isolated Rabbit Pulmonary Artery

et al. 1988

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“…In rat (41 to 255 days after birth) and rabbit (50 to 1835 days) aortae, the response to isoprenaline, but not to NaNO2, is inversely related to age, therefore, an age-dependent decrease in the aortic #-receptor activity has been postulated (Fleisch et al, 1970). In contrast, Park et al (1976) have suggested that a fi-adrenoceptor function in the aortae and pulmonary artery of new-born rabbits matures with age because of an age-dependent (1 day to 5 months) increase in the response to isoprenaline. Whether the discrepancy between our findings and those obtained by other investigators is due to differences in the experimental conditions, such as resting tensions (different or same in rabbits of different ages), contractile agents (prostaglandins, histamine, 5-HT, etc.)…”

Section: Discussionmentioning

confidence: 93%

Age‐related Changes in the Response of Rabbit Isolated Aortae to Vasoactive Agents

Hayashi

Toda

1978

British J Pharmacology

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1 In helically-cut strips of aortae from rabbits of different ages (2 to 360 days old), responses to vasoconstrictor and vasodilator agents were compared. 2 The passive tension developed by the same magnitude of stretch was markedly less in aortae from immature rabbits than in aortae from mature rabbits. 3 Contractile responses to noradrenaline and K+ increased with age in the range from 2 to 90 days. High concentrations of noradrenaline (10' and 5 x 1o-'M) produced relaxation of aortic strips from immature rabbits (2 to 30 days). The response to histamine was not altered with age. Age-dependent reductions (90 to 360 days) in the response to 5-hydroxytryptamine were observed.4 Relaxations induced by isoprenaline of aortic strips contracted with prostaglandin F2. increased with age in the range from 2 to 30 days but decreased with age from 30 to 360 days. Similar age-related alterations in the relaxant response to adenosine were observed. 5 It is concluded that aortae from immature rabbits are more distensible than those from mature rabbits; a-adrenoceptors mature during an early postnatal period (2 to 30 days), and 5-hydroxytryptamine receptor mechanisms deteriorate with age (older than 90 days). The f-receptor mechanism does not seem to alter greatly with age.

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“…opment and then decrease after maturation (9)(10)(11)(12). The effect of Because the maximum response to agents with different relaxing agents that do not operate through this receptor (e.g.…”

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confidence: 99%

Maturational Changes in the Pharmacological Characteristics and Actomyosin Content of Canine Arterial and Venous Tissue

et al. 1987

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ABSTRACT. The purpose of this study was to compare indicating intervessel heterogeneity in maturation. (Pediatr the pharmacological characteristics and actomyosin conRes 21: 152-158, 1987) tent of arterial and venous tissue at different times during Abbreviations development. Rings of arteries (femoral, renal, carotid, pulmonary) and veins (saphenous, pulmonary, jugular) PSS, physiological salt solution were obtained from 1 wk, 1 month, and adult dogs, mounted li, initial length at their optimal length for force development and the KCl, potassium chloride contractile response to potassium chloride and phenyleph-L, optimal length rine determined. The strain at optimal length was less at PE, phenylephrine all ages in pulmonary artery and pulmonary and jugular ED50, concentration that produces half maximum response veins than in other vessels. All vessels exhibited an in-SDS, sodium dodecyl sulfate crease in maximum contractile response with development but the increase was greater for phenylephrine. In general, the magnitude of the maximum response of the jugular and pulmonary veins and pulmonary artery was less than other vessels at all ages. The sensitivity (half maximum reIt has been demonstrated by several investigators (1-5) that sponse) either increased or was unchanged in arteries with the mechanical responsiveness of arterial tissue to constrictor development, while in the veins it either decreased or was and dilator agents changes during the development of the animal unchanged. The relaxant effects of verapamil and isopro-(for more complete reviews see References 6 and 7). In general, terenol were determined on potassium chloride contracted the maximum response to constrictor agents increases while the vessels. Arterial tissue was minimally responsive to isopro-sensitivity (ED50) either does not change or increases. The terenol at all ages while venous tissue either increased its particular alteration in sensitivity observed may depend on the responsiveness (saphenous, pulmonary) with development constrictor agent used, the age range studied, or the animal or remained highly responsive (jugular). Verapamil, unlike species from which the vessel was obtained. Work from this isoproterenol, was an effective relaxant of all vessels. The laboratory (8) suggests that the increase in maximum contractile actomyosin content (mglmm) of femoral and renal arteries response that occurs in developing rat aorta between the ages of and saphenous and jugular veins increased with develop-1 and 2 months can be explained in part by an increase in the ment but this increase was accompanied by a parallel actomyosin content of the vessel; however, changes in maximum increase in total protein so that the ratio (actomyosinltotal contractile response occumng earlier (5) or later (8) are not due protein) was unchanged. In jugular veins from adult dogs to changes in contractile protein content. this ratio was smaller than in arterial tissue. In general, itThe response to vasodilator agents that operate via the P can be concluded th...

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Maturation of beta-adrenergic receptor activity of rabbit aorta and pulmonary artery

Cited by 19 publications

References 4 publications

Maturation-Related Changes in Dopamine-Induced Relaxation of Isolated Rabbit Pulmonary Artery

Maturation-Related Changes in Dopamine-Induced Relaxation of Isolated Rabbit Pulmonary Artery

Age‐related Changes in the Response of Rabbit Isolated Aortae to Vasoactive Agents

Maturational Changes in the Pharmacological Characteristics and Actomyosin Content of Canine Arterial and Venous Tissue

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