Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified Aromatic-Turmerone (AR)

Tan, Yulong; Yang, Meng; Zhang, Heying; Cheng, Shih‐Jung; Wang, Qiushi; Yang, Xianghong; Zheng, Wei; Zhou, Huawei; Shan, Fengping

doi:10.4161/hv.21526

Cited by 11 publications

(3 citation statements)

References 36 publications

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“…Researchers have accumulated data on the biological activities of non-curcuminoids and revealed that these components of turmeric have similar dynamic potential as curcuminoids and exhibits non-hepatotoxic, non-mutagenic, non-carcinogenic efficiency with the fewest side effects [16]. This review pioneers to collaborate all the foregoing extensive anticancer studies on some major non-curcuminoids (Figure 2) such as ar–turmerone, β–elemene, δ-elemene, furanodiene, furanodienone, curcumol, cyclocurcumin, calebin A, germacrone, bisacurone and curdione [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,…”

Section: Non-curcuminoids As Anticancer Agentsmentioning

confidence: 99%

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Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations

Nair¹,

Amalraj²,

Jacob³

et al. 2019

Biomolecules

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Over the past decades curcuminoids have been extensively studied for their biological activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, antihypotensive, antihypocholesteremic, and anticancer activities. With the perception of limited toxicity and cost, these compounds forms an integral part of cancer research and is well established as a potential anticancer agent. However, only few studies have focused on the other bioactive molecules of turmeric, known as non-curcuminoids, which are also equally potent as curcuminoids. This review aims to explore the comprehensive potency including the identification, physicochemical properties, and anticancer mechanism inclusive of molecular docking studies of non-curcuminoids such as turmerones, elemene, furanodiene (FN), bisacurone, germacrone, calebin A (CA), curdione, and cyclocurcumin. An insight into the clinical studies of these curcumin-free compounds are also discussed which provides ample evidence that favors the therapeutic potential of these compounds. Like curcuminoids, limited solubility and bioavailability are the most fragile domain, which circumscribe further applications of these compounds. Thus, this review credits the encapsulation of non-curcuminoid components in diverse drug delivery systems such as co-crystals, solid lipid nanoparticles, liposomes, microspheres, polar-non-polar sandwich (PNS) technology, which help abolish their shortcomings and flaunt their ostentatious benefits as anticancer activities.

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Section: Non-curcuminoids As Anticancer Agentsmentioning

confidence: 99%

“…Further, the treatment with ar-turmerone downregulated the acidic phosphatase (ACP) activity inside DC, promoting interleukin (IL-12) and tumor necrosis factor-α (TNF-α) production. They also reported that both α and β-turmerones exhibited antiproliferative activities in breast cells [37].…”

Section: Non-curcuminoids As Anticancer Agentsmentioning

confidence: 99%

Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations

Nair¹,

Amalraj²,

Jacob³

et al. 2019

Biomolecules

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“…Ar-turmerone, another compound isolated from Curcuma genus, has been shown to increase the level of IL-12 in dendritic cells, which could be beneficial for the anticancer immunotherapy. 97…”

Section: Hallmarks Of Cancer and Representation Of The Indonesia Medimentioning

confidence: 99%

The Chemopreventive Activity of Indonesia Medicinal Plants Targeting on Hallmarks of Cancer

Meiyanto

Larasati

2019

Adv Pharm Bull

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Cancer remains a complex disease with increasing global mortality and morbidity. Numerous theories have been established to understand the biological mechanism underlying cancer. One of the most renowned frameworks is the hallmark of cancer proposed by Hanahan and Weinberg that covers ten eminent characteristics of cancer: (i) genome instability and mutation, (ii) sustaining proliferative signaling, (iii) evading growth suppressor, (iv) enabling replicative immortality, (v) resisting cell death, (vi) inducing angiogenesis, (vii) activating invasion and metastasis, (viii) avoiding immune destruction, (ix) tumor-promoting inflammation, and (x) deregulating cellular energetics. These hallmarks provide a rational approach to design an anticancer therapy. In the current review, we summarized specific target molecules on each hallmark of cancer. Further, we evaluated the biological activity of several Indonesia medicinal plants against those specific targets. We explicated the anticancer and chemopreventive activities of some medicinal plants that have been used for centuries by local communities in Indonesia, including Curcuma genus, Brucea javanica, Boesenbergia pandurata, Caesalpinia sappan, and Nigella sativa. Interestingly, these medicinal plants target several hallmarks of cancer, and even Curcuma genus exhibited biological activities that target all hallmarks of cancer. Further, we also discuss several strategies to develop those medicinal plants and/or their active compounds as anticancer and chemopreventive agents.

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Curcumin‐free turmeric exhibits anti‐inflammatory and anticancer activities: Identification of novel components of turmeric

Aggarwal

Wei

et al. 2013

Molecular Nutrition Food Res

265

167

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Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic, antimicrobial, wound healing, and memory-enhancing activities. One component of turmeric is curcumin, which has been extensively studied, as indicated by more than 5600 citations, most of which have appeared within the past decade. Recent research has identified numerous chemical entities from turmeric other than curcumin. It is unclear whether all of the activities ascribed to turmeric are due to curcumin or whether other compounds in turmeric can manifest these activities uniquely, additively, or synergistically with curcumin. However, studies have indicated that turmeric oil, present in turmeric, can enhance the bioavailability of curcumin. Studies over the past decade have indicated that curcumin-free turmeric (CFT) components possess numerous biological activities including anti-inflammatory, anticancer, and antidiabetic activities. Elemene derived from turmeric is approved in China for the treatment of cancer. The current review focuses on the anticancer and anti-inflammatory activities exhibited by CFT and by some individual components of turmeric, including turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrone.

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Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified Aromatic-Turmerone (AR)

Cited by 11 publications

References 36 publications

Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations

Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations

The Chemopreventive Activity of Indonesia Medicinal Plants Targeting on Hallmarks of Cancer

Curcumin‐free turmeric exhibits anti‐inflammatory and anticancer activities: Identification of novel components of turmeric

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