“…Firstly, the cellattached experiments infer the functional presence of K IR and BK channels in the sarcolemma of skeletal muscle, where K IR dominates P K under control conditions. Channel characterization is consistent with reports in literature for K IR [5,19,21,22,23,24,26,31] and BK [2,25,29,36] channels. Additionally, due to the circumstance that the activity of K IR decreases and that of BK increases following application of Iso under identical experimental conditions, it is concluded that the effect of the increased BK contribution induced by Iso exceeds the concomitant effect of the decrease of the K IR .…”