Matriz porosa do BV60S no tratamento de defeitos ósseos críticosem rádios de cães

Abstract

RESUMOO objetivo deste estudo foi avaliar o efeito da matriz porosa do biovidro de composição molar 60% SiO2 -36% CaO -4% P2O5 (BV60S) no tratamento de defeitos ósseos críticos de cães. Foram utilizados 20 cães, machos, sem raça definida, com dois anos e massa corporal média de 25kg. Foram constituídos três grupos experimentais: defeitos ósseos preenchidos com BV60S (BV), com osso autógeno (C+) e defeitos não preenchidos (C-). A regeneração óssea foi avaliada por meio de exames radiográficos, densitométricos e histomorfométricos ao longo de 90 dias. A matriz do BV60S mostrou rápida reabsorção com redução média de 12,62% a cada 15 dias. A regeneração foi completa no grupo C+ e incompleta nos grupos BV e C-, aos 90 dias. A área de neoformação óssea foi semelhante entre os grupos BV e C-, em todos os tempos estudados. Conclui-se que a matriz porosa do BV60S possui rápida reabsorção, não sendo eficiente no tratamento de defeitos ósseos críticos em rádios de cães.Palavras-chave: cão, regeneração óssea, ortopedia, biomateriais ABSTRACTThe aim of this study was to evaluate the effect of the porous matrix of bioglass with molar composition of 60% SiO2, 36% CaO, 4% P2O5 (BV60S)

Osteoprogenitor cells can enhance early bone formation in critical bone defects in dogs

“…A bone defect segment 1.5-fold greater than the diaphyseal diameter exceeds the bone regenerative capacity in dogs with skeletal maturity, resulting in non-union (KANG et al, 2012;ALVES et al, 2015b).…”

“…To control pain and inflammation we administered 3mg kg -1 SC TID tramadol (Tramadol Hydrochloride, Teuto, Brazil) and 0.2mg kg -1 IM SID meloxicam (0.2% injectable Maxicam, Ouro Fino, Brazil) for five consecutive days, as well as antibiotic therapy with cephalexin (30mg kg -1 VO, BID) for seven consecutive days. Critical bone defect was created according to KANG et al (2012) and ALVES et al (2015b) by removing a bone fragment from the middle third of the radius with an extension corresponding to 1.5 times the diameter of the bone. Bone stabilization was performed with an F318 steel bridge plate positioned on the cranial surface of the radius and fixed with six bicortical screws.…”

“…Measurements were performed using Digimizer Image Analysis software. The areas corresponding to bone growth were expressed as a percentage relative to the total area of the bone defect for each animal (ALVES et al, 2015b).…”

“…Density values of each defect were converted to percentage of region corresponding to the defects treated with autograft, considered 100%. (ALVES et al, 2015b).…”

“…Generally, critical bone defects are treated with bone grafts, preferably autogenous, that favor regeneration of the bone tissue by means of osteoconduction, osteoinduction, and osteogenesis (ALVES et al, 2015b). However, some drawbacks such as increased surgical time, complications at the collection site, local embrittlement, and a limited amount of bone graft collected, are associated with the use of autogenous bone grafts, despite this method being considered the best to date (KRAUS & BAYER, 2012).…”