2009
DOI: 10.1016/j.chom.2009.09.005
|View full text |Cite
|
Sign up to set email alerts
|

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

Abstract: Influenza A virus is an important human pathogen causing significant morbidity and mortality every year and threatening the human population with epidemics and pandemics. Therefore, it is important to understand the biology of this virus to develop strategies to control its pathogenicity. Here we demonstrate that live influenza A virus infection causes accumulation of autophagosomes by blocking their fusion with lysosomes. Matrix protein 2 is sufficient and necessary for this inhibition of autophagosome degrad… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

27
565
5
3

Year Published

2010
2010
2023
2023

Publication Types

Select...
7
3

Relationship

1
9

Authors

Journals

citations
Cited by 457 publications
(600 citation statements)
references
References 60 publications
(74 reference statements)
27
565
5
3
Order By: Relevance
“…Recent studies also provide evidence that HIV-1 Nef and the influenza M2 proteins interact with Beclin 1 and block autophagosome maturation. 68,69 These studies suggest that Beclin 1 complexes not only promote autophagosome formation but also maturation in different pathogens, which regulates host response in immunologic defense.…”
Section: Slammentioning
confidence: 99%
“…Recent studies also provide evidence that HIV-1 Nef and the influenza M2 proteins interact with Beclin 1 and block autophagosome maturation. 68,69 These studies suggest that Beclin 1 complexes not only promote autophagosome formation but also maturation in different pathogens, which regulates host response in immunologic defense.…”
Section: Slammentioning
confidence: 99%
“…In recent years, an increasing number of studies have demonstrated that the infection processes of morbilliviruses are closely related with autophagic flux [16,17]. However, the coxsackievirus B3, herpes simplex virus and influenza A virus have been shown to induce autophagosome formation but block the fusion of autophagosomes with lysosomes [4850]. More importantly, MeV infection induces successive autophagic signalling, leading to a sustained increase in autophagic flux [16].…”
Section: Discussionmentioning
confidence: 99%
“…This benefit for HIV in blocking autophagosome degradation was only observed in macrophages, but not T cells. Similarly, a slight benefit of macroautophagy regulation for the replication of the segmented RNA virus influenza virus was observed only in canine kidney epithelial cells, but not in human lung epithelia or mouse embryonic fibroblasts [65][66] . Irrespective of a benefit for viral replication, influenza infection leads to autophagosome accumulation in a broad range of cell types 66 …”
Section: Viral Evasion From Macroautophagymentioning
confidence: 99%