Matrix Metalloproteinases in Obesity After Gastric Bypass Surgery—an Experimental Study

Mirică, Radu; Ionescu, Mihai; Mirică, Alexandra; Ginghină, Octav; Iosifescu, R.; Roşca, Adrian Eugen; Găman, Laura; Zăgrean, Leon; Iordache, N

doi:10.1007/s12262-020-02462-x

Cited by 1 publication

(4 citation statements)

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“…It is well established that if a patient is obese for an extended length of time, he will get diabetes as a direct result of the food-induced obesity. Mirica et al [17] revealed statistically significant variations in preoperative blood glucose levels and weight between the control and study groups. The research demonstrates that cormparable discrepancies exist even between triglycerides (TGL) and cholesterol (CHO) levels.…”

Section: Discussionmentioning

confidence: 95%

“…MMPs play an important part in the management of adipogenesis by performing proteolytic activities throughout adipose mass growth [17].…”

Section: Obesity and Biologic Systemic Statusmentioning

confidence: 99%

“…Adipocytes, on the other hand, release proangiogenic substances such as tumor necrosis factor-α, monobutyrin [23], leptin, and vascular endothelial growth factor (VGEF). ECM components are generated and destroyed during adipocyte development, and some investigations have shown that adipocyte differentiation is modulated by the ECM environment [11,12,17].…”

mentioning

confidence: 99%

“…Not only are the advantages of bariatric surgery biological in nature, but they also seek to enhance one's quality of life. Several studies (Mirica et al [12,17]) reveal that the majority of patients who have bariatric surgery, increases their athletic performance and frequency, as well as their sexual status (p < 0.05). Additionally, 44% of patients improved their libido and intercourse quality.…”

mentioning

confidence: 99%

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Pathophysiology of metalloproteinase matrix in relation to morbid obesity and associated pathologies

Mirică

Ionescu

Ginghină

et al. 2022

The European Research Journal

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Matrix Metalloproteinases (MMPs), these calcium-dependent zinc-containing endopeptidases play an important role in adipogenesis and angiogenesis by modifying tissues and degrading the extracellular matrix (ECM). Matrix glycoproteins, gelatin, collagens, proteoglycans and elastin are all found in the ECM. Current meta-analysis confirmed the lower levels of IL-6 and CRP was found following bariatric surgery. Several studies have shown correlations between E-selectin levels, BMI, and MMP-9 levels. There was also a strong link between the metalloproteinases MMP-2 and MMP-9. MMP-2 and adiponectin levels are related. MMP-9 levels, on the other hand, were modestly linked with E-selectin and HDL cholesterol levels, as previously stated. Also current observations imply that alterations in the ECM caused by MMP-mediated degradation may be crucial for the differentiation of adipocytes. The most crucial component of this is that MMPs are involved in the remodeling of tissue after gastric bypass surgery, as revealed by these markers (especially MMP-2 and MMP-9). Thus, it is tempting to assume that adipocyte derived MMPs may constitute a novel pharmaceutical target for limiting adipose tissue development through the reduction of adipocyte differentiation and angiogenesis. MMP-2 exhibits far more accurate oscillations than MMP-9 during pre- and post-surgical weight fluctuations, and hence may be used as a predictor for gastric bypass success. The purpose of this paper is to conduct a comprehensive review of the literature with an emphasis on the critical functions that MMPs have in the pathophysiology of obesity and the related diseases.

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Section: Discussionmentioning

confidence: 95%

“…MMPs play an important part in the management of adipogenesis by performing proteolytic activities throughout adipose mass growth [17].…”

Section: Obesity and Biologic Systemic Statusmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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