Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms

Kadoglou, Nikolaos P.E.; Liapis, Christos D.

doi:10.1185/030079904125003143

Cited by 178 publications

(186 citation statements)

References 76 publications

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“…The fact that key processes such as formation of skeletal muscle, cardiac hypertophy, bone development, T-cell differentiation and neuronal survival are controlled by class IIa HDACs suggests possibilities for therapeutical intervention in numerous human pathologies. Endothelial cell dysfunction is associated with several vascular diseases, such as arteriosclerosis (Verma et al, 2004), stroke and aneurysms (Kadoglou and Liapis, 2004), as well as tumoral angiogenesis and metastasis (Ranieri and Gasparini, 2001). Dysregulation of growth plate chondrogenesis can result in dwarfism and skeletal abnormalities (Mundlos and Olsen, 1997).…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

Class IIa histone deacetylases: regulating the regulators

2007

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Section: Therapeutic Implicationsmentioning

confidence: 99%

Class IIa histone deacetylases: regulating the regulators

2007

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“…66 The Law of Laplace indicates that this move toward ECM degradation may reflect a response to elevated wall stress. Other proteolytic enzymes have also been identified in the AAA wall, 75 and their expression may be enhanced by locally acting forces. In support of this idea, an upregulation of MMP-1 has been reported in mechanically stimulated SMCs, 76 aortic endothelial cells, 77 and fibroblasts 78 in culture.…”

Section: Stress-mediated or Strain-mediated Wall Weakeningmentioning

confidence: 99%

Biomechanical Determinants of Abdominal Aortic Aneurysm Rupture

Vorp

Geest

2005

ATVB

227

172

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Abstract-Rupture of abdominal aortic aneurysm (AAA) represents a significant clinical event, having a mortality rate of 90% and being currently ranked as the 13th leading cause of death in the US. The ability to reliably evaluate the susceptibility of a particular AAA to rupture on a case-specific basis could vastly improve the clinical management of these patients. Because AAA rupture represents a mechanical failure of the degenerated aortic wall, biomechanical considerations are important to understand this process and to improve our predictions of its occurrence. Presented here is an overview of research to date related to the biomechanics of AAA rupture. This includes a summary of results related to ex vivo and in vivo mechanical testing, noninvasive AAA wall stress estimations, and potential mechanisms of AAA wall weakening. We conclude with a demonstration of a biomechanics-based approach to predicting AAA rupture on a patient-specific basis, which may ultimately prove to be superior to the widely and currently used maximum diameter criterion. Key Words: abdominal aortic aneurysm Ⅲ biomechanics Ⅲ rupture Ⅲ strength Ⅲ stress A bdominal aortic aneurysm (AAA) is a focal enlargement of the infrarenal aorta, which occurs over a time course of several years. This condition is present in Ϸ2% of the elderly population, with Ϸ150 000 new cases diagnosed each year, and the incidence is increasing. 1,2 If left untreated, AAA will gradually expand until rupture; it is an event that carries a mortality rate of 90% and that is ranked as the 13th most common cause of death in the US. 3 Current AAA repair procedures are expensive and carry significant morbidity and mortality risks.Open repair of AAA is a major surgical procedure that requires patients to be hospitalized typically for 1 week and to recuperate at home for several more weeks. The mean postoperative mortality for elective repair is Ϸ5% and for emergency operations 47% (range 27% to 69%). 4 The major drawback of open repair is the compromised quality of life after surgery because of postoperative pain, the prolonged recovery period, and the high costs associated with both the surgery and the recovery.An alternative approach that avoids the extensive tissue dissection associated with open repair is the minimally invasive endovascular repair procedure. The potential advantages of endovascular AAA repair include reductions in mortality, morbidity, blood loss, hospital stay, intensive careOriginal

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“…Retention of the amino-terminal propeptides leads to incorporation into the fibril of the partially processed form pN-collagen, resulting in abnormal connective tissue formation (22). A tight balance between synthesis and breakdown of ECM is required for the function of all tissues, and dysregulation leads to pathophysiological events, such as arthritis, cancer, atherosclerosis, aneurysms, and fibrosis (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34).…”

mentioning

confidence: 99%

Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation

Burke

Ding

Singh

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

305

252

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Type I fibrillar collagen is the most abundant protein in the human body, crucial for the formation and strength of bones, skin, and tendon. Proteolytic enzymes are essential for initiation of the assembly of collagen fibrils by cleaving off the propeptides. We report that Mep1a −/− and Mep1b −/− mice revealed lower amounts of mature collagen I compared with WT mice and exhibited significantly reduced collagen deposition in skin, along with markedly decreased tissue tensile strength. While exploring the mechanism of this phenotype, we found that cleavage of full-length human procollagen I heterotrimers by either meprin α or meprin β led to the generation of mature collagen molecules that spontaneously assembled into collagen fibrils. Thus, meprin α and meprin β are unique in their ability to process and release both C-and N-propeptides from type I procollagen in vitro and in vivo and contribute to the integrity of connective tissue in skin, with consequent implications for inherited connective tissue disorders.proteolysis | Ehlers-Danlos syndrome | proteomics | fibrosis | connective tissue

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Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms

Cited by 178 publications

References 76 publications

Class IIa histone deacetylases: regulating the regulators

Class IIa histone deacetylases: regulating the regulators

Biomechanical Determinants of Abdominal Aortic Aneurysm Rupture

Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation

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