Matrix Metalloproteinases as Markers of Acute Inflammation Process in the Pulmonary Tuberculosis

Abstract

The main factors of pathogenesis in the pulmonary tuberculosis are not only the bacterial virulence and sensitivity of the host immune system to the pathogen, but also the degree of destruction of the lung tissue. Such destruction processes lead to the development of caverns, in most cases requiring surgical interventions besides the drug therapy. Identification of special biochemical markers allowing to assess the necessity of surgery or therapy prolongation remains a challenge. We consider promising markers—metalloproteinases—analyzing the data obtained from patients with pulmonary tuberculosis infected by different strains of Mycobacterium tuberculosis. We argue that the presence of drug-resistant strains in lungs leading to complicated clinical prognosis could be justified not only by the difference in medians of biomarkers concentration (as determined by the Mann–Whitney test for small samples), but also by the qualitative difference in their probability distributions (as detected by the Kolmogorov–Smirnov test). Our results and the provided raw data could be used for further development of precise biochemical data-based diagnostic and prognostic tools for pulmonary tuberculosis.

SARS-CoV-2 Persistence: Data Summary up to Q2 2020

“…Recently, the contamination and decontamination of inanimate surfaces has been discussed. Inactivation time of the Sars-CoV-2 on surfaces (liquid, solid or gaseous) is still debated [12][13][14][15][16][17][18][19]]. The exposed surfaces to this type of transmission route include:…”

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Are Potential Biomarkers of Pulmonary and Extra-Pulmonary Tuberculosis

“…TIMPs are very important factors for TB disease, involved in tissue remodeling and repair upon destruction created by MMPs (17,18). Previous studies have identified MMPs as markers of disease severity, bacterial burdens and as a biomarker for disease in PTB and EPTB (17,(19)(20)(21). Relatively, few studies have focused on examining the circulating levels of MMPs and TIMPs as immune biomarkers in both PTB and EPTB.…”

An Improved Diagnostic of the Mycobacterium tuberculosis Drug Resistance Status by Applying a Decision Tree to Probabilities Assigned by the CatBoost Multiclassifier of Matrix Metalloproteinases Biomarkers

“…as a consequence, the concentration of these biomolecules can serve as potential biomarkers [ 13 , 15 ]. Recently, a relatively large dataset of MMPs and TIMP concentrations obtained from patients with the confirmed various drug resistance status of MtB has been published [ 16 ]. This opens up prospects for their evaluation as potential indicators to distinguish between sensitive, MDR, and XDR forms, as well as between healthy and infected persons.…”