2003
DOI: 10.1074/jbc.m209196200
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Matrix Metalloproteinases Are Differentially Expressed in Adipose Tissue during Obesity and Modulate Adipocyte Differentiation

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Cited by 400 publications
(396 citation statements)
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“…In the same study, Alexander et al noted that MMP3 Ϫ/Ϫ mice backcrossed onto another background (FVB/N) became obese with age (17). In contrast to our study, both Maquoi et al (5), in an earlier study, and Chavey et al (4) found that MMP3 expression levels were upregulated in adipose tissue isolated from obese mice. The reasons for these disparities with our results are unclear.…”
Section: Discussioncontrasting
confidence: 74%
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“…In the same study, Alexander et al noted that MMP3 Ϫ/Ϫ mice backcrossed onto another background (FVB/N) became obese with age (17). In contrast to our study, both Maquoi et al (5), in an earlier study, and Chavey et al (4) found that MMP3 expression levels were upregulated in adipose tissue isolated from obese mice. The reasons for these disparities with our results are unclear.…”
Section: Discussioncontrasting
confidence: 74%
“…However, we have previously shown that the expression level of endothelial cell-specific molecule 2, a corollary of endothelial contamination, was consistent among these subjects (14). MMPs may play an important role in adipose tissue remodeling (4,5). In two previous studies, Chavey et al (4) and Maquoi et al (5) examined the expression levels of various MMPs and TIMPs (tissue inhibitors of MMP) in adipose tissue from mouse models of obesity.…”
Section: Discussionmentioning
confidence: 87%
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“…23 mRNA levels for MMP-2, MMP-3, MMP-12, MMP-14, MMP-19 and TIMP-1 are strongly induced in obese adipose tissues in a genetic or a diet-induced model of obesity. 24 The treatment of cultured preadipocytes with either synthetic MMP inhibitors or neutralizing antibodies decreases differentiation. 22 These previous studies using cultured adipocytes suggest that MMP activity is required for adipocyte conversion.…”
Section: Discussionmentioning
confidence: 99%