Matrix metalloproteinases and TIMP in acute respiratory distress syndrome.

Ricou, Bara; Nicod, Laurent P.; Lacraz, S; Welgus, Howard G.; Suter, Peter M.; Dayer, Jean‐Michel

doi:10.1164/ajrccm.154.2.8756805

Cited by 181 publications

(112 citation statements)

References 26 publications

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“…It has been reported that the activity of this enzyme markedly increases after experimental lung injury induced by endotoxin (41), pancreatitis (24), or mechanical ventilation (14). Likewise, MMP-9 levels have been found to be elevated in patients with acute respiratory distress syndrome (13,40). Our results show an increase in MMP-9 activity and MMP-8 levels after high-pressure ventilation in lung homogenates and BAL fluid, whereas MMP-2 increases substantially only in the latter.…”

Section: Discussionsupporting

confidence: 52%

See 1 more Smart Citation

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

Albaiceta¹,

Gutiérrez‐Fernández²,

Parra³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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Section: Discussionsupporting

confidence: 52%

“…Among them, MMP-9 (gelatinase B) has gained some attention in different models of lung injury (39,42) including VILI (14,25). The levels of MMP-9 have also been found to be raised in patients with acute lung injury (13,40,50). MMP-9 is stored in neutrophil granules, being rapidly released after cellular activation (36).…”

mentioning

confidence: 99%

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

Albaiceta¹,

Gutiérrez‐Fernández²,

Parra³

et al. 2008

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…This involves pro-and anti-inflammatory cytokines [122,123]. Other molecules such as oxygen radicals, platelet activating factor and metabolites of arachidonic acid, proteases, coagulation cascade and complement play an important role in the inflammatory response [124,125]. These factors can be produced by the various cells of the alveolar structure.…”

Section: Management Of Lung Diseases In Childrenmentioning

confidence: 99%

Bronchoalveolar lavage in children

Blic¹,

Midulla²,

Barbato³

et al. 2000

eur respir j

348

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Bronchoalveolar lavage (BAL) is routinely performed in adults for sampling cellular and biochemical components. Many studies have been performed that have enabled the proposal of recommendations for BAL, methodology and processing, as well as reference values in different clinical settings. In contrast, despite a world-wide increase in the use of BAL in children, including neonates, there are, at the present time, no clear recommendations on the methodology, the clinical applications and the research areas for BAL. A Task Force on BAL in children has been approved by the European Respiratory Society (ERS) Task Force committee 1996. The objectives of this task force were: 1) to provide recommendations and guidelines on how to perform BAL and how to process the return fluid in children; 2) to collect and discuss available reference values; 3) to list indications and results in both immunocompetent and immunocompromised children; 4) to define areas for future research.This task force included paediatric respiratory physicians involved in bronchoscopy and BAL and was run as a collaboration between the Paediatric Bronchology Group and the BAL scientific group of the ERS.

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“…The progression of BPD is characterized by extensive tissue remodeling of the ECM as well as the disruption of the basement membrane, resulting in increased vascular permeability and edema in the early stage. Although the local MMP-2 and MMP-9 activities were variable as sampled from the bronchoalveolar fluid (20), the respective plasma concentrations were not examined. Intracranial hemorrhage is a common complication in preterm infants (11) and involves both vascular and platelet lesions as well as hypoxia-reoxygenation injury (19).…”

mentioning

confidence: 99%

MMP-2 and MMP-9 and Their Tissue Inhibitors in the Plasma of Preterm and Term Neonates

et al. 2004

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Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are involved in a variety of physiologic growth and development and pathophysiologic inflammatory conditions. We hypothesized that 1) MMP-2 and -9 plasma activities and TIMP-1 and -2 plasma concentrations in preterm and term neonates were dependent on the gestational and postnatal age; and 2) the respective MMP and their inhibitors were deranged in the development of bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH) in preterm neonates. From 1998 to 1999, blood samples were collected from preterm neonates (25-36 wk gestation) with or without BPD and/or IVH as well as from healthy term (37-40 wk gestation) neonates during the first 28 d of life. MMP-2 and MMP-9 plasma activities were measured by zymography; TIMP-1 and TIMP-2 plasma concentrations were determined by ELISA. In neonates without BPD or IVH (n ϭ 50), MMP-2 and MMP-9 plasma activities both appeared to be gestational age dependent, with the highest levels observed in neonates of 33-36 wk gestation. TIMP-1 plasma concentration was highest in term neonates but no gestational difference was found in TIMP-2. Only MMP-9 showed a 50% decrease after d 1 in the first postnatal month. Twelve preterm infants with BPD and/or IVH had significantly lower MMP-2 but higher MMP-9 activity and higher TIMP-1 concentration than those of corresponding neonates without BPD or IVH. These findings show the gestational age-dependent expression of plasma MMP activities and their inhibitors. MMP and TIMP may be involved in the feto-neonatal development and may contribute to the pathogenesis of BPD and/or IVH in critically ill preterm neonates. MMP are a group of zinc-dependent endopeptidases involved in the process of tissue remodeling through the degradation of the ECM. Tissue remodeling occurs in various physiologic conditions, such as embryogenesis and wound healing, as well as in pathologic conditions, including inflammatory diseases, tumor cell invasion, and angiogenesis (1). Among the MMP, MMP-2 (gelatinase A: pro-enzyme, 72 kD, constitutive) and MMP-9 (gelatinase B: pro-enzyme, 92 kD, inducible) are of particular interest because of their novel roles other than tissue remodeling. Recently, MMP-2 has been found to play a role in acute disease processes such as platelet aggregation (2), the regulation of vascular tone (3), and myocardial dysfunction after ischemia-reperfusion (4). Whereas both MMP-2 and MMP-9 are activated through proteolytic cleavage and/or oxidative stress (5), the proteolytic function of MMP is at least in part inhibited by tissue inhibitors of MMP (TIMP) (6). Thus, imbalances between MMP and TIMP may result in an increased proteolytic activity and therefore promote the progression of pathologic conditions such as inflammatory and myocardial diseases (1, 4) and intracerebral hemorrhage (7).Both term and preterm neonates have to undergo various adaptive processes to environmental conditions ex utero, including an enhanced oxidative stress. However, the organ systems of...

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Matrix metalloproteinases and TIMP in acute respiratory distress syndrome.

Cited by 181 publications

References 26 publications

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

Bronchoalveolar lavage in children

MMP-2 and MMP-9 and Their Tissue Inhibitors in the Plasma of Preterm and Term Neonates

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