Matrix metalloproteinases and their inhibitors in gingival mast cells in persons with and without human immunodeficiency virus infection

Næsse, E. P.; Schreurs, Olav; Helgeland, Kristen; Schenck, Karl; Steinsvoll, Svein

doi:10.1034/j.1600-0765.2003.00687.x

Cited by 41 publications

(56 citation statements)

References 63 publications

(110 reference statements)

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“…This finding effectively confirmed the same finding of an increase in the mast cell population in NDV infection. The result was consistent with previous studies (Hattori et al, 1989;Chen et al, 2000;Naesse et al, 2003) showing that tryptase was largely within mast cells. Besides tryptase, a number of mediators released during mast cell degranulation, such as histamine and tumour necrosis factor, can also contribute to innate defence (Gonzalez-Espinosa et al, 2003;Dawicki & Marshall, 2007;Pejler et al, 2007).…”

Section: Discussionsupporting

confidence: 83%

“…Such potential roles include the ability to act as antigenprocessing and presenting cells, although this function so far has been demonstrated primarily in vitro (Eager et al, 1989;Frandji et al, 1993Frandji et al, , 1998Fox et al, 1994) or by the adoptive transfer of antigen-treated mast cells in vivo (Villa et al, 2001). Mast cells also have the potential to influence the migration, maturation, and/or function of dendritic cells (Caron et al, 2001;Cumberbatch et al, 2001;Stoitzner et al, 2001) and to influence the biology of other cell types that contribute to these responses, including T cells and B cells (Mekori & Metcalfe, 1999;Nakajima et al, 2002;Sayama et al, 2002;Okumura et al, 2003). In this study we observed an increased ratio of mast cells in the proventriculus, duodenum, jejunum and caecal tonsil.…”

Section: Discussionmentioning

confidence: 99%

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Increased mast cell density during the infection with velogenic Newcastle disease virus in chickens

et al. 2008

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In addition to their well-characterized role in allergic inflammation, recent data confirm that mast cells play a more extensive role in a variety of viral infections. The contribution of mast cells to Newcastle disease pathogenesis has not been investigated. We evaluated mast cell activity after Newcastle disease virus (NDV) infection in specific pathogen free chickens using cytochemical and immunocytochemical analyses. The results were as follows. Severe tissue damage was observed in the proventriculus, duodenum, jejunum and caecal tonsil, and NDV antigens were detected and presented extensively in these tissues. Second, in the NDV-infected group, the mast cell population was increased markedly in the proventriculus, duodenum, jejunum and caecal tonsil at 24, 48, 72 and 96 h after infection (PB0.01). However, very few mast cells were observed in those same tissues in the control. More intriguingly, the greatest number of mast cells was found in the proventriculus, which also showed the greatest level of NDV antigens. Third, the content of tryptase was significantly higher (PB0.01) in the NDV-infected group compared with the control from 24 to 96 h post infection). Furthermore, as an important protease released by mast cells, tryptase had a positive correlation with mast cell distribution. These data indicated that mast cells were involved in the response to NDV. Our results also suggested that the broad range of mast cell mediators might have a role in the pathology of Newcastle disease.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Increased mast cell density during the infection with velogenic Newcastle disease virus in chickens

et al. 2008

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“…The secreted inflammatory mediators participate in angiogenesis, tissue remodeling and wound healing, which include both degradation and synthesis of tissue components. Among these, nitric oxide (NO) (Bridi et al 1997) and matrix metalloproteinases (MMPs) (Naesse et al 2003;Di Girolamo et al 2006;Yoshinori et al 2007) have been strongly correlated with periodontal diseases (PDs), since they are the major players in collagen breakdown during periodontal tissue destruction (Hannas et al 2007). …”

Section: Introductionmentioning

confidence: 99%

Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat

et al. 2008

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The immunopathologic and inflammatory mechanisms involved in periodontal disease (PD) include the participation of host resident, inflammatory cells and chemical mediators. Metalloproteinases (MMPs) and nitric oxide (NO) play essential role in extracellular matrix turnover of periodontal tissue destruction. In this study, by means of RT-PCR through semi-quantitative densitometric scanning methods, the expression of MMPs -2 and -9 and inducible NO synthase (iNOS) was temporally and spatially investigated during the destructive mechanisms of experimentally induced PD in rats. Samples from different periods were microscopically analyzed and compared with the contralateral side (control). Our results showed significant expression of MMP-9 and iNOS in tissues affected by PD, as compared with controls, three days after PD induction, simultaneously with the beginning of alveolar bone loss. At 7 days post induction, only the MMP-9 mRNA presented a significantly higher expression, as compared with the respective controls. Thus, in the rat ligature-induced PD, MMP-9 and iNOS might importantly participate in the early stages of the disease, including inflammatory cell migration, tissue destruction and alveolar bone resorption. Also, we may suggest that the exuberant presence of PMNs may be related to the important expression of iNOS and MMP-9 found at 3 days post induction.

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“…The increase in the number of mast cells in cervical DOI: 10.5114/ceji.2012.32729 lymph nodes of HIV-positive men, as compared with healthy subjects, were observed [11], and a significantly higher mast cell count were found in the chorionic epithelium of the uterine cervix of HIV-infected women than of non-HIV-infected [12]. Also, the gingival tissue of HIV-1-positive patients with chronic marginal periodontitis as well as healthy gingiva displayed higher mast cell density in comparison with non-infected counterparts [13,14]. These findings could suggest that mast cells are directly or indirectly affected by HIV-1 and associated with infection aftermaths, including AIDS progression.…”

mentioning

confidence: 79%

Are mast cells the Trojan horse in HIV-1 infection?

Witczak¹,

Brzezińska‐Błaszczyk²

2012

cejoi

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Matrix metalloproteinases and their inhibitors in gingival mast cells in persons with and without human immunodeficiency virus infection

Abstract: The chronically inflamed periodontal lesions in the present study appeared with little evidence of mast cell degranulation. The results show, however, that mast cells in inflamed gingiva have the potential to degrade extracellular matrix if appropriately triggered.

Cited by 41 publications

References 63 publications

Increased mast cell density during the infection with velogenic Newcastle disease virus in chickens

Increased mast cell density during the infection with velogenic Newcastle disease virus in chickens

Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat

Are mast cells the Trojan horse in HIV-1 infection?

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